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MiR-222 regulates the progression of oral squamous cell carcinoma by targeting CDKN1B.

Objective: The purpose of this study was to establish a causal relationship between microRNA (miR-222) and oral squamous cell carcinoma (OSCC). Methods: The cell viability of each treatment group was measured by MTT. The effects of miR-222 on cell metastasis ...

Heterogeneity of the COVID-19 epidemic: what can we learn from it?

Objectives: The goal of this article is to evaluate and explain the heterogeneity of the Coronavirus disease 2019 (COVID-19) epidemic in Australia, to offer advice for stopping the current outbreak and preparing for a suitable response to epidemics in ...

The effectiveness of diet intervention in improving the metabolism of overweight and obese women: a systematic review and meta-analysis.

Objectives: Dietary therapy may improve glucose and lipid metabolism function in women. However, there is no systematic review to investigate the association between metabolic effects and different dietary interventions in obese women. The main purpose ...

IL-12RB1: a novel immune prognostic biomarker for oral squamous cell carcinoma and linked to PD-1/PD-L1 expression in the tumor immune microenvironment.

This study aimed to screen and identify potential immune biomarker to predict the prognosis of oral squamous cell carcinoma (OSCC).Data of OSCC patient from The Cancer Genome Atlas (TCGA) database were downloaded, and the ESTIMATE algorithm was used to ...

Analysis of gastrointestinal function and prognostic value of tumor markers in patients with laparoscopic radical resection of colorectal cancer.

Objective: To analyze the gastrointestinal function and prognostic value of tumor markers (TMs) in patients with laparoscopic radical resection of colorectal cancer (LRRCC). Methods: The research population of this retrospective study comprised 141 patients ...

Identification of prognostic candidate signatures by systematically revealing transcriptome characteristics in lung adenocarcinoma with differing tumor microenvironment immune phenotypes.

, Zhou Q, Chen L. IRF8 induces senescence of lung cancer cells to exert its tumor suppressive function. Cell Cycle. 2019; 18:3300–12. 10.1080/15384101.2019.1674053 [PMC free article] [PubMed] [CrossRef

Development and Validation of Prognostic Nomograms for Periampullary Neuroendocrine Neoplasms: A SEER Database Analysis.

(1) Background: Periampullary neuroendocrine neoplasms (NENs) are rare tumors that lack a prognostic prediction model. We aimed to design comprehensive and effective nomograms to predict prognosis; (2) Methods: Univariate and multivariate Cox analyses ...

Non-mass enhancement breast lesions: MRI findings and associations with malignancy.

Magnetic resonance imaging (MRI) is a multi-sequence imaging technique. Although MRI is the most sensitive method for detecting breast cancer, it is limited in evaluating the malignant possibility of non-mass enhanced (NME) breast lesions. It is also ...

CircSOX9 acts as a molecular sponge of miR-485-3p to promote the progression of nasopharyngeal carcinoma.

Circular RNA (circRNA) plays a vital role in the occurrence and development of nasopharyngeal carcinoma (NPC). However, the role of certain specific circRNAs in NPC are still unknown. In this study, collect tumor samples and adjacent normal tissues from ...

Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy.

, et al. Isotopic graphene-isolated-Au-nanocrystals with cellular Raman-silent signals for cancer cell pattern recognition . Chem Sci 2018 ; 9 : 2842e9 . 16. Zhu A , Jiao T , Ali S , Xu Y , Ouyang Q ... , Chen Q. SERS sensors based on aptamer-gated mesoporous silica nanoparticles for quantitative detection of Staphylococcus aureus with signal molecular release . Anal Chem 2021 ; 93 : 9788e96 . 17. Ling X

Non-linear relationship between baseline mean arterial pressure and 30-day mortality in patients with sepsis: a retrospective cohort study based on the MIMIC-III database.

Cao, Q Chen, T Tang; (II) Administrative support: Q He, Y Chen; (III) Provision of study materials or patients: X Zhong, H Li; (IV) Collection and assembly of data: H Li, P Hao; (V) Data analysis and

Construction and validation of a biochemical signature to predict the prognosis and the benefit of induction chemotherapy in patients with nasopharyngeal carcinoma.

This study aimed to develop and validate a biochemical signature for predicting the prognosis of patients with nasopharyngeal carcinoma (NPC) and explore roles of the constructed signature for screening optimal candidates for induction chemotherapy (IC). ...

Biomedical relation extraction via knowledge-enhanced reading comprehension.

In biomedical research, chemical and disease relation extraction from unstructured biomedical literature is an essential task. Effective context understanding and knowledge integration are two main research problems in this task. Most work of relation ...

SweepCluster: A SNP clustering tool for detecting gene-specific sweeps in prokaryotes.

The gene-specific sweep is a selection process where an advantageous mutation along with the nearby neutral sites in a gene region increases the frequency in the population. It has been demonstrated to play important roles in ecological differentiation ...

High Glucose-Induced Kidney Injury via Activation of Necroptosis in Diabetic Kidney Disease.

Diabetic kidney disease (DKD) is a major microvascular complication of diabetes mellitus (DM) and is closely associated to programmed cell death. However, the complex mechanisms of necroptosis, an alternative cell death pathway, in DKD pathogenesis are ...

A study on the esophageal dynamics in patients with gastroesophageal reflux disease and with refractory cough undergoing esophageal high-resolution manometry.

Objective: To analyze the esophageal dynamics in patients with gastroesophageal reflux disease (GERD) and with refractory cough while undergoing esophageal high-resolution manometry (HRM). Methods: A total of 32 patients with GERD and with refractory ...

B3GNT3 as a prognostic biomarker and correlation with immune cell infiltration in lung adenocarcinoma.

, China Corresponding author. Contributions: (I) Conception and design: Q Chen; (II) Administrative support: Q Chen; (III) Provision of study materials or patients: Y Wu; (IV) Collection and assembly of

New classification for advanced breast cancer patients experiencing disease progression during salvage treatment: a single-center retrospective cohort study.

equally. Contributions: (I) Conception and design: Q Chen, Z Yuan; (II) Administrative support: L Ren; (III) Provision of study materials or patients: J Wen; (IV) Collection and assembly of data: J Li, L ... Huang; (V) Data analysis and interpretation: J Wen, Q Chen; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. #These authors contributed equally to this work

MiR-195-5p suppresses the proliferation, migration, and invasion of gallbladder cancer cells by targeting FOSL1 and regulating the Wnt/β-catenin pathway.

support: G Li, Y Wan; (III) Provision of study materials or patients: J Wu, X Zhou; (IV) Collection and assembly of data: H Zhu, Q Chen, Y Liang; (V) Data analysis and interpretation: H Zhu, Z Chen, J Yu

Incidence and mortality of gastric cancer in 2018 and their trends from 2010 to 2018 in Henan Province, China: results from a provincial population-based cancer registry.

Corresponding author. #Contributed equally. Contributions: (I) Conception and design: S Zhang, Q Chen; (II)Administrative support: S Zhang, B Han; (III) Provision of study materials or patients: S Zhang, Q Chen ... , L Guo; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: Q Chen, H Xu, Y Liu, X Wang, C Cheng; (VI) Manuscript writing: All authors; (VII) Final approval of