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The Effect of Sr Modifier Additions on Double Oxide Film Defects in 2L99 Alloy Castings

In this paper, Sr modifier (300 ppm) was added to 2L99 alloy sand castings to investigate its effect on bifilm defects in the castings. Two different sand molds were used in this study, with good and bad running system designs, to introduce different amounts of bifilm defects into the castings. The mechanical properties of the modified 2L99 castings were compared to the properties ...

Sclerosing angiomatoid nodular transformation of the spleen in a patient with Maffucci syndrome: a case report and review of literature

Maffucci syndrome is a congenital, non-hereditary mesodermal dysplasia characterized by multiple enchondromas and hemangiomas. The presence of visceral vascular lesions in this syndrome is exceedingly rare. We report a 26-year-old female who was diagnosed with Maffucci syndrome along with sclerosing angiomatoid nodular transformation (SANT) of the spleen. The patient underwent a ...

Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies

of China (NSFC) (81371740, 81371741, 81630082, 81573039 and 91542124). Author Contributions Conceptualization: Sui-Qing Cai, Min Zheng. Data curation: Min Min, Lilla Landeck, Jia-Qi Chen. Formal ... analysis: Min Min, Ping Wang, Xiao-Yong Man. Funding acquisition: Sui-Qing Cai, Min Zheng, Xiao-Yong Man. Investigation: Min Min, Bing-Xi Yan, Ping Wang, Jia-Qi Chen, Wei Li. Methodology: Lilla Landeck

Evaluation of the efficacy of a commercial inactivated genogroup 2b-based porcine epidemic diarrhea virus (PEDV) vaccine and experimental live genogroup 1b exposure against 2b challenge

Porcine epidemic diarrhea virus strains from the G1b cluster are considered less pathogenic compared to the G2b cluster. The aim of this study was to compare the ability of G1b-based live virus exposure against use of a commercial G2b–based inactivated vaccine to protect growing pigs against G2b challenge. Thirty-nine PEDV naïve pigs were randomly divided into five groups: ...

Seasonal dynamics and spatial distribution pattern of Parapoynx crisonalis (Lepidoptera: Crambidae) on water chestnuts

authors would like to thank Dr. Cecil L. Smith (University of Georgia, USA) for editing the English language of the manuscript. Author Contributions Data curation: Ni Li, Qi Chen. Formal analysis: Ni Li ... , Qi Chen. Funding acquisition: Guo-Hua Huang. 11 / 13 Investigation: Ni Li, Qi Chen, Jie Zhu, Jian-Bin Huang. Methodology: Xing Wang, Guo-Hua Huang. Project administration: Guo-Hua Huang. Validation

eComment. Neoadjuvant chemoradiotherapy: where is the real controversy?

Authors: Long-Qi Chen 0 Han-Yu Deng 0 Zhi-Qiang Wang 0 0 Department of Thoracic Surgery, West China Hospital of Sichuan University , Chengdu, Sichuan, China doi:10.1093/icvts/ivw341 V [3] van Hagen

Characterizing the rapid spread of porcine epidemic diarrhea virus (PEDV) through an animal food manufacturing facility

. Woodworth, Rodger G. Main, Steve S. Dritz, Cassandra K. Jones. Data curation: Roger A. Cochrane, Charles R. Stark, Jason C. Woodworth, Jianfa Bai, Elizabeth G. Poulsen, Qi Chen, Rodger G. Main, Jianqiang

Age-stage, two-sex life table of Parapoynx crisonalis (Lepidoptera: Pyralidae) at different temperatures

Parapoynx crisonalis is an important pest of many aquatic vegetables including water chestnuts. Understanding the relationship between temperature variations and the population growth rates of P. crisonalis is essential to predicting its population dynamics in water chestnuts ponds. These relationships were examined in this study based on the age-stage, two-sex life table of P. ...

Impact of smoking on health-related quality of Life after percutaneous coronary intervention treated with drug-eluting stents: a longitudinal observational study

Background Smoking has been shown to reduce health-related quality of life (HRQOL) in patients with coronary artery disease (CAD) undergoing percutanous coronary intervention (PCI) either by means of balloon angioplasty or with the use of bare-metal stents (BMS). Drug-eluting stents (DES) have now been widely used and are related to substantial reduction of restenosis and ...

Can mitomycin facilitate endoscopic dilatation treatment of benign oesophageal stricture?

A best evidence topic in cardiothoracic surgery was written according to a structured protocol. The question addressed was ‘Can mitomycin facilitate endoscopic dilatation treatment of benign esophageal stricture (mainly including caustic and anastomotic esophageal stricture)?’ Altogether, 115 papers were found using the reported search, of which 6 represented the best evidence to ...

Methylation-Sensitive Melt Curve Analysis of the Reprimo Gene Methylation in Gastric Cancer

Reprimo (RPRM) is a p53-induced tumor suppressor gene. Its aberrant DNA methylation is correlated with carcinogenesis and may be used as a surrogate marker for the early detection of gastric cancer. However, the detail information regarding its DNA methylation has not been revealed. Here, we investigated the RPRM gene methylation in gastric cancer tumor and plasma samples by ...

Reconstruction of 3D structures of MET antibodies from electron microscopy 2D class averages

Dynamics of three MET antibody constructs (IgG1, IgG2, and IgG4) and the IgG4-MET antigen complex was investigated by creating their atomic models with an integrative experimental and computational approach. In particular, we used two-dimensional (2D) Electron Microscopy (EM) images, image class averaging, homology modeling, Rapidly exploring Random Tree (RRT) structure sampling, ...

Role of keratin 24 in human epidermal keratinocytes

Keratin 24 (K24) is a new kind of keratin genes, which encodes a novel keratin protein, K24 that bears high similarity to the type I keratins and displays a unique expression profile. However, the role of K24 is incompletely understood. In our study, we investigated the localization of K24 within the epidermis and possible functions. Keratin 24 was found to be modestly ...

The Arginine/Lysine-Rich Element within the DNA-Binding Domain Is Essential for Nuclear Localization and Function of the Intracellular Pathogen Resistance 1

The mouse intracellular pathogen resistance 1 (Ipr1) gene plays important roles in mediating host immunity and previous work showed that it enhances macrophage apoptosis upon mycobacterium infection. However, to date, little is known about the regulation pattern of Ipr1 action. Recent studies have investigated the protein-coding genes and microRNAs regulated by Ipr1 in mouse ...

Effect of the retinal size of a peripheral cue on attentional orienting in two- and three-dimensional worlds

It has been documented that due to limited attentional resources, the size of the attentional focus is inversely correlated with processing efficiency. Moreover, by adopting a variety of two-dimensional size illusions induced by pictorial depth cues (e.g., the Ponzo illusion), previous studies have revealed that the perceived, rather than the retinal, size of an object determines ...

The Role of Parieto-Occipital Junction in the Interaction between Dorsal and Ventral Streams in Disparity-Defined Near and Far Space Processing

Neuropsychological and functional MRI data suggest that two functionally and anatomically dissociable streams of visual processing exist: a ventral perception-related stream and a dorsal action-related stream. However, relatively little is known about how the two streams interact in the intact brain during the production of adaptive behavior. Using functional MRI and a virtual ...

Type 2 diabetes mellitus and risk of colorectal adenoma: a meta-analysis of observational studies

Background To summarize the relationship between type 2 diabetes mellitus (T2DM) and risk of colorectal adenomas (CRA), we performed a meta-analysis of observational studies. Methods To find studies, we searched PubMed, Embase, the Cochrane Library, Web of Science and conference abstracts and related publications for American Society of Clinical Oncology and the European Society of ...

Targeting Epithelial-Mesenchymal Transition for Identification of Inhibitors for Pancreatic Cancer Cell Invasion and Tumor Spheres Formation

Background Pancreatic cancer has an enrichment of stem-like cancer cells (CSCs) that contribute to chemoresistant tumors prone to metastasis and recurrence. Drug screening assays based on cytotoxicity cannot identify specific CSC inhibitors, because CSCs comprise only a small portion of cancer cell population, and it is difficult to propagate stable CSC populations in vitro for ...