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53 papers found.
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Temporal and spatial evolution characteristics of water environment quality in Heze

The evolution of water environment is relatively complicated. The study of its characteristics is helpful to grasp the general direction of spatial and temporal evolution of water environment in Heze city, and to carry out water resources development and water environment protection more rationally. The comprehensive pollution index method for calculation, and the observed data...

A Synthetic Aperture Radar Image Model of Ship on Sea

Double scattering between the ship and sea surface is an important characteristic for ship detection. Based on geometrical optics (GO), a modified GO-GO solution is presented to evaluate the double scattering from sea and the tilt facets of ship at high frequency. Direct scattering contributions from ship and sea are evaluated by using physical optics (PO). To get a synthetic...

Insulin resistance enhances the mitogen-activated protein kinase signaling pathway in ovarian granulosa cells

helpful discussion. Author Contributions Formal analysis: Linghui Kong. Funding acquisition: Yong Wang. Conceptualization: Linghui Kong, Qien Wang, Shanmei Shen, Qian Gao, Yong Wang. Investigation ... : Linghui Kong, Qien Wang, Jiewen Jin. Methodology: Linghui Kong, Qien Wang, Jiewen Jin, Yong Wang. Project administration: Shanmei Shen, Hongwei Wang, Qian Gao, Yong Wang. Resources: Hongwei Wang, Qian Gao

Guidelines for Biomarker of Food Intake Reviews (BFIRev): how to conduct an extensive literature search for biomarker of food intake discovery

Gao 0 Augustin Scalbert 2 Guy Vergères 1 Marjukka Kolehmainen 7 Claudine Manach 6 Lorraine Brennan 5 Sri Harsha Pedapati 5 Lydia A. Afman 4 David S. Wishart 9 Rosa Vázquez-Fresno 9 Cristina Andres

A scheme for a flexible classification of dietary and health biomarkers

Biomarkers are an efficient means to examine intakes or exposures and their biological effects and to assess system susceptibility. Aided by novel profiling technologies, the biomarker research field is undergoing rapid development and new putative biomarkers are continuously emerging in the scientific literature. However, the existing concepts for classification of biomarkers in...

MicroRNA-144-3p inhibits autophagy activation and enhances Bacillus Calmette-Guérin infection by targeting ATG4a in RAW264.7 macrophage cells

MicroRNAs (miRNAs) are small noncoding nucleotides that play major roles in the response of host immune cells. Autophagy plays a key role in activating the antimicrobial host defense against Mycobacterium tuberculosis (M. tuberculosis). Whether miRNAs specifically influence the activation of macrophage autophagy during M. tuberculosis infection is largely unknown. In the present...

Deep Whole-Genome Sequencing to Detect Mixed Infection of Mycobacterium tuberculosis

: Qian Gao) and the National Science and Technology Major Project [2013ZX10004903-006] (website:http://www. most.gov.cn/index.htm) (PI: Qian Gao). The funders had no role in study design, data collection

Analysis of antibiotics selection in patients undergoing appendectomy in a Chinese tertiary care hospital

Qian Gao Ting Zhang Shigong Guo 0 Department of Emergency Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing 100730 , China

Mesoscale numerical simulation study of warm fog dissipation by salt particles seeding

Based on the dynamic framework of WRF and Morrison 2-moment explicit cloud scheme, a salt-seeding scheme was developed and used to simulate the dissipation of a warm fog event during 6–7 November 2009 in the Beijing and Tianjin area. The seeding effect and its physical mechanism were studied. The results indicate that when seeding fog with salt particles sized 80 µm and at a...

Plasma microRNAs are associated with acute exacerbation in idiopathic pulmonary fibrosis

Background Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) has high short-term mortality with unknown causes. To predict this malignant condition in clinics is challenging. In this study, we aim to demonstrate whether there are miRNAs that differ between AE-IPF and stable IPF, which may be served as reliable biomarker for AE-IPF prediction. Methods Human fibrotic...

The FBPase Encoding Gene glpX Is Required for Gluconeogenesis, Bacterial Proliferation and Division In Vivo of Mycobacterium marinum

Lipids have been identified as important carbon sources for Mycobacterium tuberculosis (Mtb) to utilize in vivo. Thus gluconeogenesis bears a key role for Mtb to survive and replicate in host. A rate-limiting enzyme of gluconeogenesis, fructose 1, 6-bisphosphatase (FBPase) is encoded by the gene glpX. The functions of glpX were studied in M. marinum, a closely related species to...

Artemisinin mimics calorie restriction to extend yeast lifespan via a dual-phase mode: a conclusion drawn from global transcriptome profiling

Calorie restriction (CR) promotes longevity among distinct organisms from yeast to mammals. Although CR-prolonged lifespan is believed to associate with enhanced respiratory activity, it is apparently controversial for accelerated energy consumption regardless of insufficient nutrient intake. In reconciling the contradiction of less food supply versus much metabolite dispense, we...

Multilocus Sequence Typing of Pathogenic Candida albicans Isolates Collected from a Teaching Hospital in Shanghai, China: A Molecular Epidemiology Study

Molecular typing of Candida albicans is important for studying the population structure and epidemiology of this opportunistic yeast, such as population dynamics, nosocomial infections, multiple infections and microevolution. The genetic diversity of C. albicans has been rarely studied in China. In the present study, multilocus sequence typing (MLST) was used to characterize the...

Psychometric properties of the Chinese version of the pediatric quality of life inventory 4.0 Generic core scales among children with short stature

Hui Li 0 Qian Gao 1 0 Department of growth and development, Capital Institute of Pediatrics , Ya-Bao Road, Chao-Yang District, Beijing , China 1 Maternal and Child Care Service Centre of Chao-Yang

A rapid NGS strategy for comprehensive molecular diagnosis of Birt-Hogg-Dubé syndrome in patients with primary spontaneous pneumothorax

Background Primary spontaneous pneumothorax (PSP) or pulmonary cysts is one of the manifestations of Birt-Hogg-Dube syndrome (BHDS) that is caused by heterozygous mutations in FLCN gene. Most of the mutations are SNVs and small indels, and there are also approximately 10 % large intragenic deletions and duplications of the mutations. These molecular findings are generally...

The difference between Asian and Western in the effect of LDL-C lowering therapy on coronary atherosclerotic plaque: a meta-analysis report

Wen-Qian Gao Xiu-Jing Zhang Ya Huang 0 Yun-Dai Chen 0 0 The Department of Cardiology, Chinese PLA General Hospital , Fuxing Road 28, Beijing 100853 , China Background: The different effects of LDL-C

Novel Missense Variants of ZFPM2/FOG2 Identified in Conotruncal Heart Defect Patients Do Not Impair Interaction with GATA4

Conotruncal heart defect (CTD) is a complex form of congenital heart disease and usually has a poor prognosis. ZFPM2/FOG2 encodes a transcription cofactor that interacts with GATA4 to regulate cardiac development. This regulation has been established in knockout mouse models that display a range of heart malformations, especially CTD. Although previous studies have identified...

Establishment of a High-Throughput Assay to Monitor Influenza A Virus RNA Transcription and Replication

Influenza A virus (IAV) poses significant threats to public health because of the recent emergence of highly pathogenic strains and wide-spread resistance to available anti-influenza drugs. Therefore, new antiviral targets and new drugs to fight influenza virus infections are needed. Although IAV RNA transcription/replication represents a promising target for antiviral drug...