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The possibility of healing alveolar bone defects with simvastatin thermosensitive gel: in vitro/in vivo evaluation

The possibility of healing alveolar bone defects with simvastatin thermosensitive gel: in vitro/in vivo evaluation Hong Ruan, Youcheng Yu, Xuehua Guo, Qian Jiang, Ying Luo Department of Stomatology

Altered gut microbiome promotes proteinuria in mice induced by Adriamycin

Inflammation has recently been attributed to dysbiosis of the gut microbiome, which has been linked to proteinuria in chronic kidney disease. Since Adriamycin® (ADR) is widely used to induce proteinuria in mouse models, the aim of this study was to explore the potential effect of gut microbiome on this process. Both ADR resistant (C57BL/6) and susceptible (BALB/C) strains were...

MeDReaders: a database for transcription factors that bind to methylated DNA

Understanding the molecular principles governing interactions between transcription factors (TFs) and DNA targets is one of the main subjects for transcriptional regulation. Recently, emerging evidence demonstrated that some TFs could bind to DNA motifs containing highly methylated CpGs both in vitro and in vivo. Identification of such TFs and elucidation of their physiological...

Shift of bacterial community structure along different coastal reclamation histories in Jiangsu, Eastern China

Bao AuthorsSearch for Jianfeng Hua in:Nature Research journals • PubMed • Google Scholar Search for Youzhi Feng in:Nature Research journals • PubMed • Google Scholar Search for Qian Jiang in:Nature

Two phenolic antioxidants in Suoyang enhance viability of •OH-damaged mesenchymal stem cells: comparison and mechanistic chemistry

Background Suoyang originates from a psammophyte named Cynomorium songaricum Rupr and has been known as a phenolic-antioxidant-enriched traditional Chinese herbal medicine. The present study attempted to investigate the protective effect of phenolic antioxidants in Suoyang towards •OH-mediated MSCs and then further discusses the chemical mechanisms.MethodsThe lyophilized aqueous...

The mechanism of (+) taxifolin’s protective antioxidant effect for •OH-treated bone marrow-derived mesenchymal stem cells

The natural dihydroflavonol (+) taxifolin was investigated for its protective effect on Fenton reagent-treated bone marrow-derived mesenchymal stem cells (bmMSCs). Various antioxidant assays were used to determine the possible mechanism. These included •OH-scavenging, 2-phenyl-4, 4, 5, 5-tetramethylimidazoline-1-oxyl-3-oxide radical-scavenging (PTIO•-scavenging), 1, 1-diphenyl-2...

Friedreich Ataxia: Hypoplasia of Spinal Cord and Dorsal Root Ganglia

After Friedreich’s description in 1877, depletion of myelinated fibers in the dorsal columns, dorsal spinocerebellar and lateral corticospinal tracts, and neuronal loss in the dorsal nuclei of Clarke columns were considered unique and essential neuropathological features of Friedreich ataxia (FA). Lack of large neurons in dorsal root ganglia (DRG), thinning of dorsal roots (DR...

Small activating RNA binds to the genomic target site in a seed-region-dependent manner

RNA activation (RNAa) is the upregulation of gene expression by small activating RNAs (saRNAs). In order to investigate the mechanism by which saRNAs act in RNAa, we used the progesterone receptor (PR) gene as a model, established a panel of effective saRNAs and assessed the involvement of the sense and antisense strands of saRNA in RNAa. All active saRNAs had their antisense...

A theoretical insight into morphological operations in surface measurement by introducing the slope transform

As one of the tools for surface analysis, morphological operations, although not as popular as linear convolution operations (e.g., the Gaussian filter), are really useful in mechanical surface reconstruction, surface filtration, functional simulation, etc. By introducing the slope transform originally developed for signal processing into the field of surface metrology, an...

Mumps virus-induced innate immune responses in mouse Sertoli and Leydig cells

, 100005, ChinaHan Wu, Lili Shi, Qing Wang, Lijing Cheng, Xiang Zhao, Qiaoyuan Chen, Qian Jiang & Daishu HanInstitute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, 650118, ChinaMin Feng ... Chen in:Nature Research journals • PubMed • Google ScholarSearch for Qian Jiang in:Nature Research journals • PubMed • Google ScholarSearch for Min Feng in:Nature Research journals • PubMed • Google

Population variation in total genetic risk of Hirschsprung disease from common RET, SEMA3 and NRG1 susceptibility polymorphisms

The risk of Hirschsprung disease (HSCR) is ∼15/100 000 live births per newborn but has been reported to show significant inter-individual variation from the effects of seven common susceptibility alleles at the RET, SEMA3 and NRG1 loci. We show, by analyses of these variants in 997 samples from 376 HSCR families of European ancestry, that significant genetic risk can only be...

Effects of E2HSA, a Long-Acting Glucagon Like Peptide-1 Receptor Agonist, on Glycemic Control and Beta Cell Function in Spontaneous Diabetic db/db Mice

, Quan Liu, Sujuan Sun, Qian Jiang, Chunming Jia, and Zhufang Shen State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical

Biochemical and molecular characteristics of leaf photosynthesis and relative seed yield of two contrasting rice cultivars in response to elevated [CO2]

Understanding the basis for intraspecific yield variability may be important in elucidating biological mechanisms that are associated with superior yield performance in response to projected increases in carbon dioxide concentration, [CO2]. Using a free-air CO2 enrichment (FACE) facility, two rice lines, S63 and W14, which differed consistently in their enhancement of seed yield...

Morphological and functional characteristics of human gingival junctional epithelium

Background This study aims to observe the morphological characteristics and identify the function characteristics of junctional epithelium (JE) tissues and cultured JE cells. Methods Paraffin sections of human molar or premolar on the gingival buccolingual side were prepared from 6 subjects. HE staining and image analysis were performed to measure and compare the morphological...

Selection of Suitable Reference Genes for qPCR Normalization under Abiotic Stresses and Hormone Stimuli in Carrot Leaves

Carrot, a biennial herb of the Apiaceae family, is among the most important vegetable crops in the world. In this study, nine candidate reference genes (GAPDH, ACTIN, eIF-4α, PP2A, SAND, TIP41, UBQ, EF-1α, and TUB) were cloned from carrot. Carrot plants were subjected to abiotic stresses (heat, cold, salt, and drought) and hormone stimuli (gibberellin, salicylic acid, methyl...

Annular pancreas in Trichorhinophalangeal syndrome type II with 8q23.3-q24.12 interstitial deletion

Background Trichorhinophalangeal syndrome type II (TRPS II, OMIM # 150230) is a rare autosomal dominant genetic disorder characterized by craniofacial and skeletal abnormalities. Loss of functional copies of the TRPS1 gene at 8q23.3 and the EXT1 gene at 8q24.11 are considered to be responsible for the syndrome. Case Presentation Herewith, we report an 8-year-old girl with sparse...

Circulating Endothelial Progenitor Cells Decrease in Infants with Bronchopulmonary Dysplasia and Increase after Inhaled Nitric Oxide

Background Impairment of endothelial progenitor cells (EPCs) has been shown to contribute to the development of bronchopulmonary dysplasia (BPD). In the current study, the relationship between EPC changes of after birth and the development of BPD was investigated, and the effects of inhaled nitric oxide (iNO) on EPCs were evaluated. Methods Sixty infants with a gestational age of...

CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia

The WHO 2008 definition of chronic neutrophilic leukemia (CNL) is based on clinical and laboratory parameters but not on molecular abnormalities. Mutations in CSF3R, SETBP1 and CALR are reported in patients with chronic neutrophilic leukemia (CNL). However, because CNL is rare, there are few large studies of this issue. We sequenced these genes in 14 patients who met the WHO...

De Novo Transcriptome Sequence Assembly and Identification of AP2/ERF Transcription Factor Related to Abiotic Stress in Parsley (Petroselinum crispum)

Parsley is an important biennial Apiaceae species that is widely cultivated as herb, spice, and vegetable. Previous studies on parsley principally focused on its physiological and biochemical properties, including phenolic compound and volatile oil contents. However, little is known about the molecular and genetic properties of parsley. In this study, 23,686,707 high-quality...