Qian Sun An Dingsun Hui Yang www.nature.com/scientificreports We present a systematic study of surface band bending in Ga-polar n-GaN with different Si doping concentrations by angular dependent X-ray
Excessive fatty acid release from the white adipose tissue (WAT) contributes to the development of alcoholic liver disease (ALD). Lipin1 (LPIN1), as a co-regulator of DNA-bound transcription factors and a phosphatidic acid (PA) phosphatase (PAP) enzyme that dephosphorylates PA to form diacylglycerol (DAG), is dramatically reduced by alcohol in the WAT. This study aimed at...
Genetically engineered T cells expressing a T-cell receptor (TCR) are powerful tools for cancer treatment and have shown significant clinical effects in sarcoma patients. However, mismatch of the introduced TCR α/β chains with endogenous TCR may impair the expression of transduced TCR, resulting in an insufficient antitumor capacity of modified T cells. Here, we report the...
Chronic alcohol feeding causes lipid accumulation and apoptosis in the liver. This study investigated the role of bioactive lipid metabolites in alcohol-induced liver damage and tested the potential of targeting arachidonate 15-lipoxygenase (ALOX15) in treating alcoholic liver disease (ALD). Results showed that chronic alcohol exposure induced hepatocyte apoptosis in association...
G protein-coupled receptors (GPCRs) can integrate extracellular signals via allosteric interactions within dimers and higher-order oligomers. However, the structural bases of these interactions remain unclear. Here, we use the GABAB receptor heterodimer as a model as it forms large complexes in the brain. It is subjected to genetic mutations mainly affecting transmembrane 6 (TM6...
BackgroundDrug resistance remains as one of the major challenges in melanoma therapy. It is well known that tumour cells undergo phenotypic switching during melanoma progression, increasing melanoma plasticity and resistance to mitogen-activated protein kinase inhibitors (MAPKi).MethodsWe investigated the melanoma phenotype switching using a partial reprogramming model to de...
Rongfeng Li Yuping Deng He Ding Guoqing Lv Guanlei Zhao Lei Liu Guisheng Zou Meixin Feng Qian Sun Lan Yin Xing Sheng 1 2 0 School of Materials Science and Engineering and Hangzhou Innovation Institute
The limited information about the sludge quality has made its management a top environmental challenge. In the present study, occurrence and the spatiotemporal variations of 52 inorganic elements were investigated in the sludge samples from three wastewater treatment plants (WWTPs) in Xiamen city, China. The results showed, the occurrence of 49 elements with the concentrations in...
AffiliationsKey Laboratory of Intelligent Agricultural Equipment of Jiangsu Province, College of Engineering, Nanjing Agricultural University, Nanjing 210031, ChinaXinxin Chen, Qishuo Ding, Qian Sun, Ruiyin He ... Błaszkiewicz in:Nature Research journals • PubMed • Google ScholarSearch for Jiuai Sun in:Nature Research journals • PubMed • Google ScholarSearch for Qian Sun in:Nature Research journals • PubMed • Google
We propose and numerically investigate a novel ultra-high quality (Q) factor metallic micro-cavity based on concentric double metal-insulator-metal (MIM) rings (CDMR). In this CDMR cavity, because of the angular momentum matching, the strong coupling occurs between the same order modes of the inner and outer rings with huge resonance frequency difference. Consequently, the energy...
, Nankai University, Tianjin, 300071, ChinaYane Wang, Jiwei Qi, Chongpei Pan, Qiang Wu, Jianghong Yao, Zongqiang Chen, Jing Chen, Yudong Li, Xuanyi Yu, Qian Sun & Jingjun XuCollaborative Innovation Center of ... Extreme Optics, Shanxi University, Taiyuan, Shanxi, 030006, ChinaYane Wang, Jiwei Qi, Chongpei Pan, Qiang Wu, Jianghong Yao, Zongqiang Chen, Jing Chen, Yudong Li, Xuanyi Yu, Qian Sun & Jingjun Xu
Undertaking behaviour is an essential activity in social insects. Corpses are often recognized by a postmortem change in a chemical signature. Reticulitermes flavipes responded to corpses within minutes of death. This undertaking behaviour did not change with longer postmortem time (24 h); however, R. flavipes exhibited distinctively different behaviours toward dead termites from...
Qian Sun Guang-Yin Xu Hong-Hong Zhang OPEN The present study was designed to investigate the roles of P2X3 receptors in dorsal root ganglion (DRG) neurons in colonic hypersensitivity and the effects of
AffiliationsInstitute of Computing Technology, Chinese Academy of Sciences, No.6 Kexueyuan South Road Zhongguancun, Haidian District, 100190, Beijing, ChinaXiao-Qian Sun, Hua-Wei Shen & Xue-Qi Cheng AuthorsSearch for ... Xiao-Qian Sun in:Nature Research journals • PubMed • Google ScholarSearch for Hua-Wei Shen in:Nature Research journals • PubMed • Google ScholarSearch for Xue-Qi Cheng in:Nature Research journals
The effect of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) has been recognized as a factor in graft failure (GF) in patients who underwent umbilical cord blood transplantation (UBT), matched unrelated donor transplantation (MUDT), or haploidentical stem cell transplantation (haplo-SCT). Presently, we know little about the prevalence of and risk factors for...
Seed germination is a critical and complex process in the plant life cycle. Although previous studies have found that melatonin can promote seed germination under salt stress, the involvement of melatonin in the regulation of proteomic changes remains poorly understood. In this study, a total of 157 proteins were significantly influenced (ratio ≥ 2 or ≤ −2) by melatonin during...
Intercellular communication between malignant cells and neighboring nonmalignant cells is involved in carcinogenesis. In the progression of carcinogenesis, exosomes are messengers for intercellular communication. Circular RNAs (circRNAs) are noncoding RNAs with functions that include regulation of the cell cycle and proliferation. However, the functions of exosomal circRNAs are...
Arresting cell cycle has been one of the most common approaches worldwide in cancer therapy. Specifically, arresting cells in the G2/M phase is a promising therapeutic approach in the battle against lung cancer. In the present study, we demonstrated the anticancer activities and possible mechanism of compound #2714, which can prompt G2/M phase arrest followed by cell apoptosis...
Direct bandgap III-V semiconductor lasers grown on silicon (Si) are highly desired for monolithic integration with Si photonics. Fabrication of semiconductor lasers with a Fabry–Pérot cavity usually includes facet cleavage, however, that is not compatible with on-chip photonic integration. Etching as an alternative approach holds a great advantage in preparing cavity mirrors with...
