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Activation of the hedgehog pathway in human hepatocellular carcinomas

Liver cancers, the majority of which are hepatocellular carcinomas (HCCs), rank as the fourth in cancer mortality worldwide and are the most rapidly increasing type of cancer in the United States. However, the molecular mechanisms underlying HCC development are not well understood. Activation of the hedgehog pathway is shown to be involved in several types of gastrointestinal...

Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment

The p75 neurotrophin receptor (p75NTR) is expressed by neurons particularly vulnerable in Alzheimer's disease (AD). We tested the hypothesis that non-peptide, small molecule p75NTR ligands found to promote survival signaling might prevent Aβ-induced degeneration and synaptic dysfunction. These ligands inhibited Aβ-induced neuritic dystrophy, death of cultured neurons and A...

Design and synthesis of boronic-acid-labeled thymidine triphosphate for incorporation into DNA

The boronic acid moiety is a versatile functional group useful in carbohydrate recognition, glycoprotein pull-down, inhibition of hydrolytic enzymes and boron neutron capture therapy. The incorporation of the boronic-acid group into DNA could lead to molecules of various biological functions. We have successfully synthesized a boronic acid-labeled thymidine triphosphate (B-TTP...

SOCIOECONOMIC AND BEHAVIOR RISK FACTORS OF HUMAN ALVEOLAR ECHINOCOCCOSIS IN TIBETAN COMMUNITIES IN SICHUAN, PEOPLE’S REPUBLIC OF CHINA

0 Organization Collaborating Centre on Prevention and Treatment of Human Echinococcosis, SERF Research Unit, Universit e de Franche-Comt e , 25030 Besanon, France 1 QIAN WANG, JIAMIN QIU, WEN YANG ... Program), and the Sichuan Provincial Health Department. Qian Wang was supported by a PhD grant from the French Embassy, French Ministry of Foreign Affairs, in Beijing, Peoples Republic of China.

c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis

Introduction Tyrosine kinases are key mediators of multiple signaling pathways implicated in rheumatoid arthritis (RA). We previously demonstrated that imatinib mesylate--a Food and Drug Administration (FDA)-approved, antineoplastic drug that potently inhibits the tyrosine kinases Abl, c-Kit, platelet-derived growth factor receptor (PDGFR), and c-Fms--ameliorates murine...

Landscape Composition and Spatial Prediction of Alveolar Echinococcosis in Southern Ningxia, China

Background Alveolar echinococcosis (AE) presents a serious public health challenge within China. Mass screening ultrasound surveys can detect pre-symptomatic AE, but targeting areas identified from hospital records is inefficient regarding AE. Prediction of undetected or emerging hotspots would increase detection rates. Voles and lemmings of the subfamily Arvicolinae are...

Hemoglobinopathy: Molecular Epidemiological Characteristics and Health Effects on Hakka People in the Meizhou Region, Southern China

Background Hemoglobinopathies are the most common inherited diseases in southern China. However, there have been only a few epidemiological studies of hemoglobinopathies in Guangdong province. Materials and Methods Peripheral blood samples were collected from 15299 “healthy” unrelated subjects of dominantly ethnic Hakka in the Meizhou region, on which hemoglobin electrophoresis...

Identification and expression profile of a putative basement membrane protein gene in the midgut of Helicoverpa armigera

amount of isopropanol in PBS without RH-2485 was injected. Authors' contributions Jia-Lin Wang carried out immunoblotting. Xiao-Juan Jiang performed Northern blot. Qian Wang completed immunohistochemistry

Synthesis and characterization of bionanoparticle—Silica composites and mesoporous silica with large pores

A sol-gel process has been developed to incorporate bionanoparticles, such as turnip yellow mosaic virus, cowpea mosaic virus, tobacco mosaic virus, and ferritin into silica, while maintaining the integrity and morphology of the particles. The structures of the resulting materials were characterized by transmission electron microscopy, small angle X-ray scattering, and N2...

SMYD1, the myogenic activator, is a direct target of serum response factor and myogenin

SMYD1 is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. We demonstrated that the expression of SMYD1 is restricted in the heart and skeletal muscle tissues in human. To reveal the regulatory mechanisms of SMYD1 expression during myogenesis and cardiogenesis, we cloned and...

Establishment of a New Cell Line from Lepidopteran Epidermis and Hormonal Regulation on the Genes

When an insect molts, old cuticle on the outside of the integument is shed by apolysis and a new cuticle is formed under the old one. This process is completed by the epidermal cells which are controlled by 20-hydroxyecdysone (20E) and juvenile hormone. To understand the molecular mechanisms of integument remolding and hormonal regulation on the gene expression, an epidermal cell...

Transgenic Expression of Entire Hepatitis B Virus in Mice Induces Hepatocarcinogenesis Independent of Chronic Liver Injury

Hepatocellular carcinoma (HCC), the third leading cause of cancer deaths worldwide, is most commonly caused by chronic hepatitis B virus (HBV) infection. However, whether HBV plays any direct role in carcinogenesis, other than indirectly causing chronic liver injury by inciting the host immune response, remains unclear. We have established two independent transgenic mouse lines...

Prioritizing risk pathways: a novel association approach to searching for disease pathways fusing SNPs and pathways

Motivation: Complex diseases are generally thought to be under the influence of one or more mutated risk genes as well as genetic and environmental factors. Many traditional methods have been developed to identify susceptibility genes assuming a single-gene disease model (‘single-locus methods’). Pathway-based approaches, combined with traditional methods, consider the joint...

Uncovering packaging features of co-regulated modules based on human protein interaction and transcriptional regulatory networks

Background Network co-regulated modules are believed to have the functionality of packaging multiple biological entities, and can thus be assumed to coordinate many biological functions in their network neighbouring regions. Results Here, we weighted edges of a human protein interaction network and a transcriptional regulatory network to construct an integrated network, and...

Factors Influencing Chinese Male's Willingness to Undergo Circumcision: A Cross-Sectional Study in Western China

Background Male circumcision (MC) has been shown to reduce the risk of female to male transmission of HIV. The goal of this survey was to explore the acceptability of MC among the Chinese and to identify factors associated with circumcision preference. Methods A cross-sectional survey was conducted between September 2009 and December 2010. We interviewed 2,219 male community...

CistromeMap: a knowledgebase and web server for ChIP-Seq and DNase-Seq studies in mouse and human

Summary: Transcription and chromatin regulators, and histone modifications play essential roles in gene expression regulation. We have created CistromeMap as a web server to provide a comprehensive knowledgebase of all of the publicly available ChIP-Seq and DNase-Seq data in mouse and human. We have also manually curated metadata to ensure annotation consistency, and developed a...

Comparison of Three Intervention Models for Promoting Circumcision among Migrant Workers in Western China to Reduce Local Sexual Transmission of HIV

the experiments: YS HL YR BW. Performed the experiments: CN JJ LY XY WD SW JH BQ HU CZ Qianqiu Wang Qian Wang FW NX PX HL. Analyzed the data: CN JJ YR HL. Wrote the manuscript: CN JJ JHH. Copyedited

Bacteriophage M13 as a scaffold for preparing conductive polymeric composite fibers

Using biological templates to build one-dimensional functional materials holds great promise in developing nanosized electrical devices, sensors, catalysts, and energy storage units. In this communication, we report a versatile assembly process for the preparation of water-soluble conductive polyaniline (PANi)/M13 composite nanowires by employing the bacteriophage M13 as a...