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Oridonin inhibits pancreatic cancer cell migration and epithelial-mesenchymal transition by suppressing Wnt/β-catenin signaling pathway

Background Oridonin (ORI) can inhibit proliferation and migration in various types of cancer cell lines. However, the exact mechanism remains unclear. We investigated the migration inhibitory effect of ORI on human pancreatic cancer SW1990 cells and dissected the possible molecular mechanism(s). Methods CCK-8 assay was used to observe the cell viability. Wound healing assay...

High Prevalence of the EBER Variant EB-8m in Endemic Nasopharyngeal Carcinomas

Epstein-Barr virus (EBV)-encoded small RNAs (EBERs) are the most highly expressed transcripts in all EBV-associated tumors and are involved in both lymphoid and epithelioid carcinogenesis. Our previous study on Chinese isolates from non-endemic area of nasopharyngeal carcinoma (NPC) identified new EBER variants (EB-8m and EB-10m) which were less common but relatively more...

Heterologous expression of human costimulatory molecule B7-2 and construction of B7-2 immobilized polyhydroxyalkanoate nanoparticles for use as an immune activation agent

Ming-Chuan Li 0 Qian-Qian Liu 0 Xiao-Yun Lu Ya-Li Zhang Lei-Lei Wang 0 Equal contributors Department of Biological Science and Bioengineering, Key Laboratory of Biomedical Information Engineering of