Equine piroplasmosis (EP) is a severe disease of horses caused by the tick-borne protozoa Theileria equi (T. equi) and Babesia caballi (B. caballi). Infectious carriers are not always symptomatic, meaning there is a risk to non-enzootic areas. Regulatory tests for EP include sero-epidemiological methods for equine babesiosis, but these lack specificity due to cross-reactivity...
KunFeng Zhang,1 QiJun Chen,1 JiaJia Wang,1 Hang Lv,2 YanYan Jiang,2 and Renbing Shi2 1School of Traditional Chinese Medicine, Capital Medical University, No. 10, Toutiao, You-An-Men-Wai Street, Beijing ... interest. Authors’ Contributions YinYing Ba designed and performed the experiments and wrote the manuscript; MengLin Wang, KunFeng Zhang, QiJun Chen, JiaJia Wang, Hang Lv, and YanYan Jiang participated in
University. He is currently working at Shanghai Normal University. His research interests include intelligent robots, biped robots, dynamics and control. Qijun Chen graduated from the Department of Automatic
, Philadelphia, Pennsylvania 19104, USATing-Lin B. Yang, Qijun Chen, Jennifer T. Deng, Geetha Jagannathan & F. Brad JohnsonCell and Molecular Biology Program, Biomedical Graduate Studies, University of ... in:Nature Research journals • PubMed • Google ScholarSearch for Qijun Chen in:Nature Research journals • PubMed • Google ScholarSearch for Jennifer T. Deng in:Nature Research journals • PubMed • Google
Background Schistosomiasis is caused by infection with blood flukes of the genus Schistosoma, and ranks, in terms of disability-adjusted life years (DALYs), as the third most important neglected tropical disease. Schistosomes have several discrete life stages involving dramatic morphological changes during their development, which require subtle gene expression modulations to...
Background Individuals living in endemic areas gradually acquire natural immunity to clinical malaria, largely dependent on antibodies against parasite antigens. There are many studies indicating that the variant antigen PfEMP1 at the surface of the parasitized red blood cell (pRBC) is one of the major targets of the immune response. It is believed that antibodies against PfEMP1...
Many studies have demonstrated a relationship between soluble B7-H3 (sB7-H3) and the poor prognosis of patients with malignant tumors, and increasing evidence has shown a connection between sB7-H3 and NF-κB in tumor progression. In the present study, we demonstrate for the first time that sB7-H3 promotes the invasion and metastasis of pancreatic carcinoma cells through the TLR4...
in:Nature Research journals • PubMed • Google ScholarSearch for Dayong Gu in:Nature Research journals • PubMed • Google ScholarSearch for Qijun Chen in:Nature Research journals • PubMed • Google ScholarSearch ... and H.T. and S.Q. are employees of SJ Biomaterials Co., LTD. SJ Bio manufactures the iPDMS membranes and peptide microarrays used in this study. Corresponding authors Correspondence to Qijun Chen or
Background Schistosomiasis is one of the most widely distributed parasitic diseases in the world. Schistosoma japonicum, a zoonotic parasite with a wide range of mammalian hosts, is one of the major pathogens of this disease. Although numerous studies on schistosomiasis japonica have been performed using laboratory animal models, systematic comparative analysis of whole-genome...
Mutually exclusive gene expression, whereby only one member of a multi-gene family is selected for activation, is used by the malaria parasite Plasmodium falciparum to escape the human immune system and perpetuate long-term, chronic infections. A family of genes called var encodes the chief antigenic and virulence determinant of P. falciparum malaria. var genes are transcribed in...
Background Recent advances in studies of the Schistosoma japonicum genome have opened new avenues for the elucidation of parasite biology and the identification of novel targets for vaccines, drug development and early diagnostic tools. Results In this study, we surveyed the S. japonicum genome database for genes encoding nucleases. A total of 130 nucleases of 3 classes were...
The digestive systems of mammals harbor a complex gut microbiome, comprising bacteria and other microorganisms that confer metabolic and immunological benefits to the host. Ruminants that digest plant-based foods have a four-compartment stomach consisting of the rumen, reticulum, omasum, and abomasum. The microorganisms in the stomach are essential for providing the host with...
Background Erythrocyte invasion by merozoites is an essential step in Plasmodium falciparum infection and leads to subsequent disease pathology. Proteins both on the merozoite surface and secreted from the apical organelles (micronemes, rhoptries and dense granules) mediate the invasion of erythrocytes; some of the molecules have been regarded as targets in the development of an...
Erythrocyte invasion by merozoites is an essential step in Plasmodium falciparum infection and leads to subsequent disease pathology. Proteins both on the merozoite surface and secreted from the apical organelles (micronemes, rhoptries and dense granules) mediate the invasion of erythrocytes; some of the molecules have been regarded as targets in the development of an anti...
Blood fluke proteases play pivotal roles in the processes of invasion, nutrition acquisition, immune evasion, and other host-parasite interactions. Hundreds of genes encoding putative proteases have been identified in the recently published schistosome genomes. However, the expression profiles of these proteases in Schistosoma species have not yet been systematically analyzed. We...
Boyin Jia 0 Zhiguang Chang 0 Xiaoyan Wei Huijun Lu Jigang Yin Ning Jiang Qijun Chen 0 Equal contributors Key Laboratory of Zoonosis, Institute of Zoonosis/College of Veterinary Medicine, Jilin
Background Schistosoma japonicum is a pathogen of the phylum Platyhelminthes that causes zoonotic schistosomiasis in China and Southeast Asian countries where a lack of efficient measures has hampered disease control. The development of tools for diagnosis of acute and chronic infection and for novel antiparasite reagents relies on understanding the biological mechanisms that the...
://www.medcalc.org/manual/kaplan-meier.php). Acknowledgements This present study was financially supported by the National Natural Science Foundation of China to Qijun Chen (grant number 81130033) and to Ning Jiang
Background Schistosomiasis is a chronic debilitating parasitic disease that afflicts more than 200 million individuals worldwide. Long-term administration of chemotherapy with the single available drug, praziquantel, has led to growing concerns about drug resistance. The PSD-95/Dlg/ZO-1 (PDZ) domain is an important module found in many scaffolding proteins, which has been...
. Anstey Qijun Chen Zinta Zommers Samir Bhatt Peter W. Gething Simon I. Hay Ananias A. Escalante, Arizona State University, United States of America Background: The simian malaria parasite, Plasmodium ... is present. Studies that have investigated malaria parasites in the monkey populations in this area have not yet found evidence of P. knowlesi infection in any of the species present (Qijun Chen
