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Nimotuzumab combined with concurrent chemoradiotherapy benefits patients with advanced nasopharyngeal carcinoma

Nimotuzumab combined with concurrent chemoradiotherapy benefits patients with advanced nasopharyngeal carcinoma Zhanzhan Li,1 Yanyan Li,2 Shipeng Yan,3 Jun Fu,1 Qin Zhou,1 Xinqiong Huang,1 Liangfang

Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization

Neuroinflammation, which ultimately leads to neuronal loss, is considered to play a crucial role in numerous neurodegenerative diseases. The neuroinflammatory process is characterized by the activation of glial cells such as microglia. Endoplasmic reticulum (ER) stress is commonly associated with impairments in neuronal function and cognition, but its relationship and role in...

Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization

Neuroinflammation, which ultimately leads to neuronal loss, is considered to play a crucial role in numerous neurodegenerative diseases. The neuroinflammatory process is characterized by the activation of glial cells such as microglia. Endoplasmic reticulum (ER) stress is commonly associated with impairments in neuronal function and cognition, but its relationship and role in...

Analysis of Seismic Soil-Structure Interaction for a Nuclear Power Plant (HTR-10)

The response of nuclear power plants (NPPs) to seismic events is affected by soil-structure interactions (SSI). In the present paper, a finite element (FE) model with transmitting boundaries is used to analyse the SSI effect on the response of NPP buildings subjected to vertically incident seismic excitation. Analysis parameters that affect the accuracy of the calculations...

Time to publication of oncology trials and why some trials are never published

, George J. Bosl, David R. Spriggs. Data curation: Paul B. Chapman, Nathan J. Liu, Sara Hanley. Formal analysis: Paul B. Chapman, Nathan J. Liu, Qin Zhou, Alexia Iasonos, David R. Spriggs. Methodology ... : Paul B. Chapman, Nathan J. Liu, Qin Zhou, Alexia Iasonos, Sara Hanley. Resources: George J. Bosl. 11 / 13 Supervision: Paul B. Chapman, Sara Hanley, David R. Spriggs. Writing ± original draft: Paul B

rLj-RGD3, a Novel Recombinant Toxin Protein from Lampetra japonica, Protects against Cerebral Reperfusion Injury Following Middle Cerebral Artery Occlusion Involving the Integrin-PI3K/Akt Pathway in Rats

Background The RGD-toxin protein Lj-RGD3 is a naturally occurring 118 amino acid peptide that can be obtained from the salivary gland of the Lampetra japonica fish. This unique peptide contains 3 RGD (Arg-Gly-Asp) motifs in its primary structure. Lj-RGD3 is available in recombinant form (rLj-RGD3) and can be produced in large quantities using DNA recombination techniques. The...

Hydrogel microphones for stealthy underwater listening

, Lincoln 68588-0526, Nebraska, USAYang Gao, Shumin Li, Qin Zhou & Li TanDepartment of Physics and Astronomy, University of Nebraska, Lincoln 68588-0299, Nebraska, USAJingfeng Song & Stephen DucharmeNebraska ... Center for Materials and Nanoscience, University of Nebraska, Lincoln 68588-0298, Nebraska, USAJingfeng Song, Shumin Li, Stephen Ducharme, Qin Zhou & Li TanCenter for Biotechnology, University of Nebraska

MicroRNA Array Normalization: An Evaluation Using a Randomized Dataset as the Benchmark

MicroRNA arrays possess a number of unique data features that challenge the assumption key to many normalization methods. We assessed the performance of existing normalization methods using two microRNA array datasets derived from the same set of tumor samples: one dataset was generated using a blocked randomization design when assigning arrays to samples and hence was free of...

Identification of Genes Associated with Smad3-dependent Renal Injury by RNA-seq-based Transcriptome Analysis

University, Guangzhou, ChinaYuanyan XiongSYSU-CMU Shunde International Joint Research Institute, Guangzhou, ChinaYuanyan Xiong AuthorsSearch for Qin Zhou in:Nature Research journals • PubMed • Google

Effects of Fentanyl on Emergence Agitation in Children under Sevoflurane Anesthesia: Meta-Analysis of Randomized Controlled Trials

Background and Objectives The goal of this meta-analysis study was to assess the effects of fentanyl on emergence agitation (EA) under sevoflurane anesthesia in children. Subjects and Methods We searched electronic databases (PubMed, Embase, Web of Science and the Cochrane Central Register of Controlled Trials) for articles published until December 2014. Randomized controlled...

Fractal Theory and Contact Dynamics Modeling Vibration Characteristics of Damping Blade

The contact surface structure of dry friction damper is complicate, irregular, and self-similar. In this paper, contact surface structure is described with the fractal theory and damping blade is simplified as 2-DOF cantilever beam model with lumped masses. By changing the position of the damper, lacing and shroud structure are separately simulated to study vibration absorption...

Naringenin Ameliorated Kidney Injury through Let-7a/TGFBR1 Signaling in Diabetic Nephropathy

,5 Qingrui Duan,5 Yixuan Sun,5 Qin Zhou,5 Lijiang Wei,6 and Zheng Zhang1,2 1Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, China 2Department of Cell

A retrospective study of the prognostic value of MRI-derived residual tumors at the end of intensity-modulated radiotherapy in 358 patients with locally-advanced nasopharyngeal carcinoma

Objective To retrospectively analyze the prognostic value of magnetic resonance imaging (MRI)-derived residual tumors after intensity-modulated radiation therapy (IMRT) in the patients with locally-advanced nasopharyngeal carcinoma. Methods A total of 358 patients with locally-advanced nasopharyngeal carcinoma who received IMRT were classified as having residual tumors or no...

Mechano-stimulated modifications in the chloroplast antioxidant system and proteome changes are associated with cold response in wheat

Background Mechanical wounding can cause morphological and developmental changes in plants, which may affect the responses to abiotic stresses. However, the mechano-stimulation triggered regulation network remains elusive. Here, the mechano-stimulation was applied at two different times during the growth period of wheat before exposing the plants to cold stress (5.6 °C lower...

Glipizide suppresses prostate cancer progression in the TRAMP model by inhibiting angiogenesis

University, Guangzhou 510006, ChinaCuiling Qi, Bin Li, Yang Yang, Yongxia Yang, Jialin Li, Qin Zhou, Yinxin Wen, Cuiling Zeng, Lingyun Zheng, Qianqian Zhang, Jiangchao Li, Xiaodong He & Lijing WangDepartment ... journals • PubMed • Google ScholarSearch for Qin Zhou in:Nature Research journals • PubMed • Google ScholarSearch for Yinxin Wen in:Nature Research journals • PubMed • Google ScholarSearch for Cuiling Zeng

Molecular characterization of the Haemonchus contortus phosphoinositide-dependent protein kinase-1 gene (Hc-pdk-1)

Background Phosphoinositide-dependent protein kinase-1 (PDK-1), which functions downstream of phosphoinositide 3-kinase (AGE-1) and activates protein kinases of the AGC family, plays critical roles in regulating biology processes, such as metabolism, growth, development and survival. In the free-living nematode Caenorhabditis elegans, PDK-1 is a key component of the insulin-like...

UXT potentiates angiogenesis by attenuating Notch signaling

Angiogenesis is spatially and temporally orchestrated by a myriad of signaling pathways, including the Notch signaling pathway. Here, we identified UXT as an evolutionarily conserved and developmentally expressed protein, indispensable for intersegmental vessel (ISV) formation in zebrafish. Deficiency of UXT in zebrafish embryos results in shorter ISVs, loss of tip cell behavior...

Age-Based Differences in the Genetic Determinants of Glycemic Control: A Case of FOXO3 Variations

Background Glucose homeostasis is a trait of healthy ageing and is crucial to the elderly, but less consideration has been given to the age composition in most studies involving genetics and hyperglycemia. Methods Seven variants in FOXO3 were genotyped in three cohorts (n = 2037; LLI, MI_S and MI_N; mean age: 92.5±3.6, 45.9±8.2 and 46.8±10.3, respectively) to compare the...

SIRT1 Is a Regulator in High Glucose-Induced Inflammatory Response in RAW264.7 Cells

Sepsis is defined as a systemic inflammatory response syndrome that disorders the functions of host immune system, including the imbalance between pro- and anti-inflammatory responses mediated by immune macrophages. Sepsis could also induce acute hyperglycemia. Studies have shown that the silent mating type information regulation 2 homolog 1 (SIRT1), an NAD+-dependent deacetylase...

Functional Roles of Three Cutin Biosynthetic Acyltransferases in Cytokinin Responses and Skotomorphogenesis

Cytokinins (CKs) regulate plant development and growth via a two-component signaling pathway. By forward genetic screening, we isolated an Arabidopsis mutant named grow fast on cytokinins 1 (gfc1), whose seedlings grew larger aerial parts on MS medium with CK. gfc1 is allelic to a previously reported cutin mutant defective in cuticular ridges (dcr). GFC1/DCR encodes a soluble...