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Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes

. Yirui Cheng, Qingyu Zeng, Qing Han and Weiliang Xia declare that they have no conflict of interest. This article does not contain any studies with human or animal subjects performed by any of the authors ... . Yirui Cheng, Qingyu Zeng, Qing Han, Weiliang Xia& OPEN ACCESS This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (

Bearing-based localization for leader-follower formation control

The observability of the leader robot system and the leader-follower formation control are studied. First, the nonlinear observability is studied for when the leader robot observes landmarks. Second, the system is shown to be completely observable when the leader robot observes two different landmarks. When the leader robot system is observable, multi-robots can rapidly form and...

Ground state solution and multiple solutions to asymptotically linear Schrödinger equations

In this paper, we consider the Schrödinger equation − Δ u + V ( x ) u = f ( x , u ) , x ∈ R N , where V and f are periodic in x 1 , … , x N , asymptotically linear and satisfies a monotonicity condition. We use the generalized Nehari manifold methods to obtain a ground state solution and infinitely many geometrically distinct solutions when f is odd in u.

Graphitic C3N4-Pt nanohybrids supported on a graphene network for highly efficient methanol oxidation

Pt heterostructures can have distinctly different physical and chemical properties to their single-phase components. Herein, a smart approach was developed for the large-scale production of graphitic C3N4-Pt (gC3N4-Pt) heterostructures on three-dimensional (3D) graphene sheet networks for highly efficient methanol oxidation. Because the gC3N4-Pt heterostructures on the conductive...

HAb18G/CD147 Regulates Vinculin-Mediated Focal Adhesion and Cytoskeleton Organization in Cultured Human Hepatocellular Carcinoma Cells

Focal adhesions (FAs), integrin-mediated macromolecular complexes located at the cell membrane extracellular interface, have been shown to regulate cell adhesion and migration. Our previous studies have indicated that HAb18G/CD147 (CD147) is involved in cytoskeleton reorganization and FA formation in human hepatocellular carcinoma (HCC) cells. However, the precise mechanisms...

Platelets induce a proinflammatory phenotype in monocytes via the CD147 pathway in rheumatoid arthritis

Introduction Activated platelets exert a proinflammatory action that can be largely ascribed to their ability to interact with monocytes. However, the mechanisms that promote dynamic changes in monocyte subsets in rheumatoid arthritis (RA) have not been clearly identified. The aim of this study was to determine whether platelet activation and the consequent formation of monocyte...

Comparison of Drip, Pipe and Surge Spring Root Irrigation for Jujube (Ziziphus jujuba Mill.) Fruit Quality in the Loess Plateau of China

Loess Plateau is a typical rain-fed farming region, facing the threat of drought. Irrigation method is among the most important factors affecting jujube quality. This study investigated the response of Ziziphus jujuba Mill. cv. Lizao quality to three different irrigation methods (drip-, pipe- and surge spring root irrigation) combining two water levels (20 m3/hm2 and 120 m3/hm2...

X-ray irradiation promotes apoptosis of hippocampal neurons through up-regulation of Cdk5 and p25

Background Cranial radiation therapy has been used for the treatment of primary and metastatic brain tumors. A prominent feature of brain injury induced by the radiation therapy is hippocampal dysfunction, characterized by a decline in memory. Cdk5 plays an important role in memory formation. Abnormal Cdk5 activity is associated with neuronal apoptosis induced by neurotoxic...

Effects of drinking water with high iodine concentration on the intelligence of children in Tianjin, China

, Faculty of Medicine, University of Sydney , Australia 2 Hong-Liang Liu, Director of Environmental Health Lawrence T. Lam, Senior Lecturer Qiang Zeng, Research Scientist Shu-qing Han, Research Scientist Gang