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Attenuation of everolimus-induced cytotoxicity by a protective autophagic pathway involving ERK activation in renal cell carcinoma cells

Attenuation of everolimus-induced cytotoxicity by a protective autophagic pathway involving ERK activation in renal cell carcinoma cells Yizhou Zeng, Xiaofang Tian, Quan Wang, Weiyang He, Jing Fan

A precise determination of the top-quark pole mass

The Principle of Maximum Conformality (PMC) provides a systematic way to eliminate the renormalization scheme and renormalization scale uncertainties for high-energy processes. We have observed that by applying PMC scale setting, one obtains comprehensive and self-consistent pQCD predictions for the top-quark pair total cross section and the top-quark pair forward–backward...

Sealing Performance and Optimization of a Subsea Pipeline Mechanical Connector

, UK 2 Authors' Information Li‐ Quan Wang born in 1957, is presently a professor at College of Mechanical and Electrical Engineering, Harbin Engineering University , China. He has been a Researchers

Tooth loss and risk of cardiovascular disease and stroke: A dose-response meta analysis of prospective cohort studies

Cheng, Mi Zhang, Jiajuan Chen. Investigation: Quan Wang. Methodology: Fei Cheng, Jiajuan Chen. Software: Quan Wang, Haijun Xu, Zhen Gao, Yunjie Wei, Fen Qin. Supervision: Fen Qin. Validation: Haijun

A promising magnetic resonance stem cell tracer based on natural biomaterials in a biological system: manganese (II) chelated to melanin nanoparticles

Hua Zhang,1 Li-Ping Li,1 Jing-Hua Sun,1 Sheng He,1 Wen Xu,1,2 Xi Yang,1 Wen-Wen Cai,2 Jian-Ding Li,1 Bin-Quan Wang,3 Rui-Ping Zhang2 1Medical Imaging Department, First Clinical Medical College of Shanxi

Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test

Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Previous literature has documented that deficits in attention are a common consequence of HIV infection. However, the precise nature of deficits of attention in HIV-infected patients is poorly understood. Accordingly, the aim of the...

Evaluating Urbanization and Spatial-Temporal Pattern Using the DMSP/OLS Nighttime Light Data: A Case Study in Zhejiang Province

The application of DMSP/OLS nighttime light data provides an effective measure for characterizing urbanization and its spatial-temporal changes. Combined with the social economic statistics and calibrated nighttime data, the nighttime light imagery of Zhejiang province was fully intercalibrated during the period 1992–2013. The backgrounds were explained and the model of region...

Microstructure and Corrosion Resistance Property of a Zn-AI-Mg Alloy with Different Solidification Processes

Zn-Al-Mg alloy coating attracted much attention due to its high corrosion resistance properties, especially high anti-corrosion performance at the cut edge. As the Zn-Al-Mg alloy coating was usually produced by hot-dip galvanizing method, solidification process was considered to influence its microstructure and corrosion properties. In this work, a Zn-Al-Mg cast alloy was melted...

A Gelatin-sulfonated Silk Composite Scaffold based on 3D Printing Technology Enhances Skin Regeneration by Stimulating Epidermal Growth and Dermal Neovascularization

Quan Wang, Heng Sun, Varitsara Bunpetch, Shufang Zhang & Hongwei OuyangZhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, Hangzhou, ChinaSi Xiong, Xianzhu Zhang, Ping Lu ... , Yan Wu, Quan Wang, Heng Sun, Varitsara Bunpetch, Shufang Zhang & Hongwei OuyangUniversity of Hong Kong, Faculty of Dentistry, Pokfulam, Hong Kong SAR, ChinaBoon Chin HengState Key Laboratory for

Systematic dissection of dysregulated transcription factor–miRNA feed-forward loops across tumor types

Transcription factor and microRNA (miRNA) can mutually regulate each other and jointly regulate their shared target genes to form feed-forward loops (FFLs). While there are many studies of dysregulated FFLs in a specific cancer, a systematic investigation of dysregulated FFLs across multiple tumor types (pan-cancer FFLs) has not been performed yet. In this study, using The Cancer...

The simulation study of three typical time frequency analysis methods

Wang 0 0 Institute of Aviation Medicine , Air Force, 100142, Beijing , China The principals and characteristics of three typical time frequency analysis methods that Short Time Furious transformation

Importance of proper renormalization scale-setting for QCD testing at colliders

A primary problem affecting perturbative quantum chromodynamic (pQCD) analyses is the lack of a method for setting the QCD running-coupling renormalization scale such that maximally precise fixed-order predictions for physical observables are obtained. The Principle of Maximum Conformality (PMC) eliminates the ambiguities associated with the conventional renormalization scale...

Atmospheric Deposition-Carried Zn and Cd from a Zinc Smelter and Their Effects on Soil Microflora as Revealed by 16S rDNA

AffiliationsCollege of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi, ChinaFeng Shen, Min Zhang, Mukesh Kumar Awasthi, Amjad Ali, Ronghua Li, Quan Wang & Zengqiang ZhangSchool of ... Research journals • PubMed • Google ScholarSearch for Ronghua Li in:Nature Research journals • PubMed • Google ScholarSearch for Quan Wang in:Nature Research journals • PubMed • Google ScholarSearch for

Uncovering the Molecular Mechanism of Actions between Pharmaceuticals and Proteins on the AD Network

This study begins with constructing the mini metabolic networks (MMNs) of beta amyloid (Aβ) and acetylcholine (ACh) which stimulate the Alzheimer’s Disease (AD). Then we generate the AD network by incorporating MMNs of Aβ and ACh, and other MMNs of stimuli of AD. The panel of proteins contains 49 enzymes/receptors on the AD network which have the 3D-structure in PDB. The panel of...

Effective Task Scheduling and IP Mapping Algorithm for Heterogeneous NoC-Based MPSoC

; Accepted 17 June 2014; Published 10 July 2014 Academic Editor: Yuping Wang Copyright © 2014 Peng-Fei Yang and Quan Wang. This is an open access article distributed under the Creative Commons Attribution

PU.1 is involved in the immune response to Aspergillus fumigatus through upregulating Dectin-1 expression

Background Invasive aspergillosis is a life-threatening disease, and its incidence has increased in the recent past. Dectin-1 recognizes β-glucans and mediates innate immune responses to Aspergillus fumigatus. Transcription factor PU.1 has been the focus of recent research due to its role in inflammation and infection. However, its role in Dectin-1 regulation during A. fumigatus...

EW_dmGWAS: edge-weighted dense module search for genome-wide association studies and gene expression profiles

Summary: We previously developed dmGWAS to search for dense modules in a human protein–protein interaction (PPI) network; it has since become a popular tool for network-assisted analysis of genome-wide association studies (GWAS). dmGWAS weights nodes by using GWAS signals. Here, we introduce an upgraded algorithm, EW_dmGWAS, to boost GWAS signals in a node- and edge-weighted PPI...

A realistic resistance deterioration model for time-dependent reliability analysis of aging bridges

Bridge resistance and reliability may deteriorate with time due to aggressive environmental conditions and increasing road freight volumes, resulting in an increase of potential economic loss. This is thus a great concern to decision-makers managing the bridges’ continued future service. Reasonable models of bridge resistance and applied loads are the fundamentals of accurate...

Robust Control for the Electrohydraulic Steering System of a Four-Wheel Vehicle

To shorten the steer diameter and to improve the maneuverability flexibility of a construction vehicle, four wheels’ steering system is presented. This steering system consists of mechanical-electrical-hydraulic assemblies. Its diagram and principle are depicted in detail. Then the mathematical models are derived step by step, including the whole vehicle model and the hydraulic...