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Tooth loss and risk of cardiovascular disease and stroke: A dose-response meta analysis of prospective cohort studies

Cheng, Mi Zhang, Jiajuan Chen. Investigation: Quan Wang. Methodology: Fei Cheng, Jiajuan Chen. Software: Quan Wang, Haijun Xu, Zhen Gao, Yunjie Wei, Fen Qin. Supervision: Fen Qin. Validation: Haijun

Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test

Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Previous literature has documented that deficits in attention are a common consequence of HIV infection. However, the precise nature of deficits of attention in HIV-infected patients is poorly understood. Accordingly, the aim of the ...

Systematic dissection of dysregulated transcription factor–miRNA feed-forward loops across tumor types

Transcription factor and microRNA (miRNA) can mutually regulate each other and jointly regulate their shared target genes to form feed-forward loops (FFLs). While there are many studies of dysregulated FFLs in a specific cancer, a systematic investigation of dysregulated FFLs across multiple tumor types (pan-cancer FFLs) has not been performed yet. In this study, using The Cancer ...

Importance of proper renormalization scale-setting for QCD testing at colliders

A primary problem affecting perturbative quantum chromodynamic (pQCD) analyses is the lack of a method for setting the QCD running-coupling renormalization scale such that maximally precise fixed-order predictions for physical observables are obtained. The Principle of Maximum Conformality (PMC) eliminates the ambiguities associated with the conventional renormalization ...

Uncovering the Molecular Mechanism of Actions between Pharmaceuticals and Proteins on the AD Network

This study begins with constructing the mini metabolic networks (MMNs) of beta amyloid (Aβ) and acetylcholine (ACh) which stimulate the Alzheimer’s Disease (AD). Then we generate the AD network by incorporating MMNs of Aβ and ACh, and other MMNs of stimuli of AD. The panel of proteins contains 49 enzymes/receptors on the AD network which have the 3D-structure in PDB. The panel of ...

PU.1 is involved in the immune response to Aspergillus fumigatus through upregulating Dectin-1 expression

Background Invasive aspergillosis is a life-threatening disease, and its incidence has increased in the recent past. Dectin-1 recognizes β-glucans and mediates innate immune responses to Aspergillus fumigatus. Transcription factor PU.1 has been the focus of recent research due to its role in inflammation and infection. However, its role in Dectin-1 regulation during A. fumigatus ...

Twenty-six circulating antigens and two novel diagnostic candidate molecules identified in the serum of canines with experimental acute toxoplasmosis

Background The protozoan Toxoplasma gondii is a pathogen that causes severe opportunistic disease in a wide range of hosts. Efficient methods to diagnose acute T. gondii infection are essential for the administration of appropriate treatments and to reduce economic losses. In animals with acute infections, circulating antigens (CAgs) were detected as early as two days ...

EW_dmGWAS: edge-weighted dense module search for genome-wide association studies and gene expression profiles

Summary: We previously developed dmGWAS to search for dense modules in a human protein–protein interaction (PPI) network; it has since become a popular tool for network-assisted analysis of genome-wide association studies (GWAS). dmGWAS weights nodes by using GWAS signals. Here, we introduce an upgraded algorithm, EW_dmGWAS, to boost GWAS signals in a node- and edge-weighted PPI ...

The Global Research Collaboration of Network Meta-Analysis: A Social Network Analysis

Background and Objective Research collaborations in biomedical research have evolved over time. No studies have addressed research collaboration in network meta-analysis (NMA). In this study, we used social network analysis methods to characterize global collaboration patterns of published NMAs over the past decades. Methods PubMed, EMBASE, Web of Science and the Cochrane Library ...

A realistic resistance deterioration model for time-dependent reliability analysis of aging bridges

Bridge resistance and reliability may deteriorate with time due to aggressive environmental conditions and increasing road freight volumes, resulting in an increase of potential economic loss. This is thus a great concern to decision-makers managing the bridges’ continued future service. Reasonable models of bridge resistance and applied loads are the fundamentals of accurate ...

Promise and Challenge of DNA Barcoding in Venus Slipper (Paphiopedilum)

Orchidaceae are one of the largest families of flowering plants, with over 27,000 species described and all orchids are listed in CITES. Moreover, the seedlings of orchid species from the same genus are similar. The objective of DNA barcoding is rapid, accurate, and automated species identification, which may be used to identify illegally traded endangered species from vegetative ...

Combined Multivariate Statistical Techniques, Water Pollution Index (WPI) and Daniel Trend Test Methods to Evaluate Temporal and Spatial Variations and Trends of Water Quality at Shanchong River in the Northwest Basin of Lake Fuxian, China

Understanding spatial and temporal variations in river water quality and quantitatively evaluating the trend of changes are important in order to study and efficiently manage water resources. In this study, an analysis of Water Pollution Index (WPI), Daniel Trend Test, Cluster Analysis and Discriminant Analysis are applied as an integrated approach to quantitatively explore the ...

Renormalization group improved pQCD prediction for Υ(1S) leptonic decay

The complete next-to-next-to-next-to-leading order short-distance and bound-state QCD corrections to Υ(1S) leptonic decay rate Γ(Υ(1S) → ℓ+ℓ−) has been finished by Beneke et al. [8]. Based on those improvements, we present a renormalization group (RG) improved pQCD prediction for Γ(Υ(1S) → ℓ+ℓ−) by applying the principle of maximum conformality (PMC). The PMC is based on ...

The plastidial retrograde signal methyl erythritol cyclopyrophosphate is a regulator of salicylic acid and jasmonic acid crosstalk

The exquisite harmony between hormones and their corresponding signaling pathways is central to prioritizing plant responses to simultaneous and/or successive environmental trepidations. The crosstalk between jasmonic acid (JA) and salicylic acid (SA) is an established effective mechanism that optimizes and tailors plant adaptive responses. However, the underlying regulatory ...

Characterization of Spirometra erinaceieuropaei Plerocercoid Cysteine Protease and Potential Application for Serodiagnosis of Sparganosis

Background Sparganosis is a neglected but important food-borne parasitic zoonosis. Clinical diagnosis of sparganosis is difficult because there are no specific manifestations. ELISA using plerocercoid crude or excretory–secretory (ES) antigens has high sensitivity but has cross-reactions with other helminthiases. The aim of this study was to characterize Spirometra erinaceieuropaei ...

Methodological Reporting of Randomized Trials in Five Leading Chinese Nursing Journals

Background Randomized controlled trials (RCTs) are not always well reported, especially in terms of their methodological descriptions. This study aimed to investigate the adherence of methodological reporting complying with CONSORT and explore associated trial level variables in the Chinese nursing care field. Methods In June 2012, we identified RCTs published in five leading ...

MSEA: detection and quantification of mutation hotspots through mutation set enrichment analysis

Many cancer genes form mutation hotspots that disrupt their functional domains or active sites, leading to gain- or loss-of-function. We propose a mutation set enrichment analysis (MSEA) implemented by two novel methods, MSEA-clust and MSEA-domain, to predict cancer genes based on mutation hotspot patterns. MSEA methods are evaluated by both simulated and real cancer data. We find ...

Down-Regulation of MicroRNA-223 Promotes Degranulation via the PI3K/Akt Pathway by Targeting IGF-1R in Mast Cells

Background Mast cells play a central role in allergic and inflammatory disorders by inducing degranulation and inflammatory mediator release. Recent reports have shown that miRNAs play an important role in inflammatory response regulation. Therefore, the role of miR-223 in mast cells was investigated. Methods The expression of miR-223 was quantified by quantitative real-time ...

Early serodiagnosis of trichinellosis by ELISA using excretory–secretory antigens of Trichinella spiralis adult worms

Background The excretory–secretory (ES) antigens of Trichinella spiralis muscle larvae (ML) are the most commonly used diagnostic antigens for trichinellosis. Their main disadvantage for the detection of anti-Trichinella IgG is false-negative results during the early stage of infection. Additionally, there is an obvious window between clinical symptoms and positive serology. ...

Genetic Structure Analysis of Spirometra erinaceieuropaei Isolates from Central and Southern China

Background Sparganosis caused by invasion of the plerocercoid larvae (spargana) of Spirometra erinaceieuropaei have increased in recent years in China. However, the population genetic structure regarding this parasite is still unclear. In this study, we used the sequences of two mitochondrial genes cytochrome b (cytb) and cytochrome c oxidase subunit I (cox1) to analyze genetic ...