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Search: authors:"Quan-Yi Zhao"

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Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model

Background Epigenetic regulation has emerged to be the critical steps for tumorigenesis and metastasis. Multiple histone methyltransferase and demethylase have been implicated as tumor suppressors or oncogenes recently. But the key epigenomic events in cancer cell transformation still remain poorly understood. Methods A breast cancer transformation model was established via stably ...