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Pathways and Patterns of Cell Loss in Verified Alzheimer’s Disease: A Factor and Cluster Analysis of Clinico-Pathological Subgroups

Thirty-seven patients with neuropathologically verified Alzheimer's disease (AD) have been studied prospectively. A principal components analysis of neuron numbers in cortical and subcortical areas revealed two variables: Variable I with high loadings for the hippocampo-parahippocampo-parietal neuron counts and Variable II with high loadings for coeruleo-frontal cell numbers...

Positive age beliefs protect against dementia even among elders with high-risk gene

campaign to combat the societal sources of negative age beliefs. Author Contributions Conceptualization: Becca R. Levy, Martin D. Slade, Luigi Ferrucci. Data curation: Martin D. Slade. Formal analysis ... : Martin D. Slade. Funding acquisition: Becca R. Levy, Robert H. Pietrzak, Luigi Ferrucci. Investigation: Becca R. Levy. Methodology: Becca R. Levy, Robert H. Pietrzak, Luigi Ferrucci. Writing ± original

Exercise program design considerations for head and neck cancer survivors

The present study aimed to establish exercise preferences, barriers, and perceived benefits among head and neck cancer survivors, as well as their level of interest in participating in an exercise program. Patients treated for primary squamous cell carcinoma of the head and neck between 2010 and 2014 were identified from the hospital database and sent a postal questionnaire pack...

Understanding ownership of patient care: A dual-site qualitative study of faculty and residents from medicine and psychiatry

education, ethics, consultation liaison psychiatry, and mentoring. Kelli A. Corning is associate director of the Internal Medicine Residency Program at the University of Washington. Mitchell R. Levy MD, is

Twenty Years of Stereotype Threat Research: A Review of Psychological Mediators

This systematic literature review appraises critically the mediating variables of stereotype threat. A bibliographic search was conducted across electronic databases between 1995 and 2015. The search identified 45 experiments from 38 articles and 17 unique proposed mediators that were categorized into affective/subjective (n = 6), cognitive (n = 7) and motivational mechanisms (n...

Decreasing incidence of inflammatory bowel disease in Eastern Canada: a population database study

Background Nova Scotia has one of the highest incidences of inflammatory bowel disease (IBD) in the world. We wished to determine trends of IBD over time. Methods All Provincial residents have government provided health insurance and all interactions with the hospital, and physician billing systems, are captured on an administrative database. We used a validated measure to define...

Collagen VI deficiency reduces muscle pathology, but does not improve muscle function, in the γ-sarcoglycan-null mouse

Muscular dystrophy is characterized by progressive skeletal muscle weakness and dystrophic muscle exhibits degeneration and regeneration of muscle cells, inflammation and fibrosis. Skeletal muscle fibrosis is an excessive deposition of components of the extracellular matrix including an accumulation of Collagen VI. We hypothesized that a reduction of Collagen VI in a muscular...

Increasing Negativity of Age Stereotypes across 200 Years: Evidence from a Database of 400 Million Words

Scholars argue about whether age stereotypes (beliefs about old people) are becoming more negative or positive over time. No previous study has systematically tested the trend of age stereotypes over more than 20 years, due to lack of suitable data. Our aim was to fill this gap by investigating whether age stereotypes have changed over the last two centuries and, if so, what may...

XIII. The role of immunotherapy in the treatment of lymphoma

R. Levy 0 0 Medicine/Oncology, Stanford Medical School , Stanford, CA , USA - Passive immunotherapy with monoclonal antibodies has transformed the treatment of lymphoma. The first demonstration of

The Contributing Role of Prevalent Belief Systems to Intergroup Attitudes and Behaviors

group for the problems of others) to avoid fixing the complex and difficult problems of society. About the Authors Sheri R. Levy is an Associate Professor of Psychology at Stony Brook University. She

Treatment of Pediatric Refractory Coccidioidomycosis With Combination Voriconazole and Caspofungin: A Retrospective Case Series

Background. Coccidioidomycosis is a spectrum of diseases caused by the dimorphic fungi Coccidioides. Current regimens for severe or disseminated disease include fluconazole, itraconazole, or amphotericin; newer triazoles (ie, voriconazole, posaconazole) have been demonstrated to be useful in refractory disease. Previous reported experience with combination triazole and...

Development of a predictive model for major adverse cardiac events in a coronary artery bypass and valve population

Background Quality improvement initiatives in cardiac surgery largely rely on risk prediction models. Most often, these models include isolated populations and describe isolated end-points. However, with the changing clinical profile of the cardiac surgical patients, mixed populations models are required to accurately represent the majority of the surgical population. Also...

An epidemiologic model to project the impact of changes in glomerular filtration rate on quality of life and survival among persons with chronic kidney disease

An epidemiologic model to project the impact of changes in glomerular filtration rate on quality of life and survival among persons with chronic kidney disease Adrian R Levy,1,2 Robert M Perkins,3 ... . injury, disease progression, end-stage renal disease epidemiology; decision model; policy analysis; cost effectiveness; acute kidney - open access to scientific and medical research adrian R levy 1,2

Evaluation of supply-side initiatives to improve access to coronary bypass surgery

Background Guided by the evidence that delaying coronary revascularization may lead to symptom worsening and poorer clinical outcomes, expansion in cardiac surgery capacity has been recommended in Canada. Provincial governments started providing one-time and recurring increases in budgets for additional open heart surgeries to reduce waiting times. We sought to determine whether...

Dynein drives nuclear rotation during forward progression of motile fibroblasts

Jennifer R. Levy 0 Erika L. F. Holzbaur ) 0 0 Department of Physiology, School of Medicine, University of Pennsylvania , Philadelphia, PA 19104-6085 , USA - Summary During directed cell migration

Covariate balance in a Bayesian propensity score analysis of beta blocker therapy in heart failure patients

Regression adjustment for the propensity score is a statistical method that reduces confounding from measured variables in observational data. A Bayesian propensity score analysis extends this idea by using simultaneous estimation of the propensity scores and the treatment effect. In this article, we conduct an empirical investigation of the performance of Bayesian propensity...

Utility values for symptomatic non-severe hypoglycaemia elicited from persons with and without diabetes in Canada and the United Kingdom

Objective To elicit societal and patient utilities associated with diabetic symptomatic non-severe hypoglycaemia for three health states: 1) rare (quarterly), 2) intermittent (monthly), 3) and frequent (weekly) hypoglycaemia episodes. Methods Using validated health states, time trade-off utilities were elicited from 51 Canadian respondents with diabetes, and 79 respondents in...

Joint Assessment of Intended and Unintended Effects of Medications: An Example Using Vascular Endothelial Growth Factor Inhibitors for Neovascular Age-Related Macular Degeneration

Eye Institute, Johns Hopkins University, Baltimore, MD 21287, USA Received 3 March 2009; Revised 31 July 2009; Accepted 2 December 2009 Academic Editor: Jie Jin Wang Copyright © 2009 Adrian R. Levy ... pegaptanib. A. Pleil and G. Zlateva are employees of Pfizer Inc. References Health Canada, “What is the progressive licensing project?” Generic, 2008. View at Google ScholarA. H. Briggs and A. R. Levy

Serious primary post-partum hemorrhage, arterial embolization and future fertility: a retrospective study of 46 cases

BACKGROUND The guidelines advise arterial embolization in case of post-partum hemorrhage. We evaluated its feasibility and the subsequent fertility. METHODS A retrospective study has been conducted in our center for the past 10 years (1996–2005). Fifty-two patients experiencing a primary post-partum hemorrhage who were resistant to medical treatment underwent uterine artery...