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Search: authors:"Rahul Jandial"

7 papers found.
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Decreasing glioma recurrence through adjuvant cancer stem cell inhibition

Decreasing glioma recurrence through adjuvant cancer stem cell inhibition Josh Neman, Rahul JandialDivision of Neurosurgery, City of Hope National Cancer Center, Duarte, CA, USAAbstract: Gliomas remain one of the most challenging solid organ tumors to treat and are marked clinically by invariable recurrence despite multimodal intervention (surgery, chemotherapy, radiation). This...

Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering

Stem cell–mediated osteogenesis: therapeutic potential for bone tissue engineering Josh Neman1, Amanda Hambrecht2, Cherie Cadry3, Rahul Jandial11Department of Neurosurgery, Beckman Research Institute, City of Hope National Cancer Center, Duarte, 2Department of Biological Sciences, University of Southern California, Los Angeles, 3Department of Public Health Sciences, University of...

Altered Expression of Polycomb Group Genes in Glioblastoma Multiforme

The Polycomb group (PcG) proteins play a critical role in histone mediated epigenetics which has been implicated in the malignant evolution of glioblastoma multiforme (GBM). By systematically interrogating The Cancer Genome Atlas (TCGA), we discovered widespread aberrant expression of the PcG members in GBM samples compared to normal brain. The most striking differences were...

Cytotoxic T Lymphocyte Trafficking and Survival in an Augmented Fibrin Matrix Carrier

Cell-based therapies have intriguing potential for the treatment of a variety of neurological disorders. One such example is genetically engineered cytotoxic T lymphocytes (CTLs) that are being investigated in brain tumor clinical trials. The development of methods for CTL delivery is critical to their use in the laboratory and clinical setting. In our study, we determined...

Stem cell horizons in intervertebral disc degeneration

Stem cell horizons in intervertebral disc degeneration Joseph Ciacci1, Allen Ho1,2, Christopher P Ames3, Rahul Jandial41Division of Neurosurgery, University of California, San Diego, La Jolla, California, USA; 2Del E Webb Neurosciences, Aging and Stem Cell Research Center, The Burnham Institute for Medical Research, La Jolla, California, USA; 3Department of Neurological Surgery...

Maria Auxiliadora Hospital in Lima, Peru as a model for neurosurgical outreach to international charity hospitals

Introduction A myriad of geopolitical and financial obstacles have kept modern neurosurgery from effectively reaching the citizens of the developing world. Targeted neurosurgical outreach by academic neurosurgeons to equip neurosurgical operating theaters and train local neurosurgeons is one method to efficiently and cost effectively improve sustainable care provided by...