An unfortunate emergence of a new virus SARS-CoV-2, causing a disease known as COVID-19, has spread all around the globe and has caused a pandemic. It primarily affects the respiratory tract and lungs in some cases causing severe organ damage and pneumonia due to overwhelming immune responses. Clinical reports show that the most commons symptoms are fever, dry cough, and...
. Methodology: Yoko Ito, Reem Al Mubarak, Nicole Roberts, Kelly Correll, Hong Wei Chu. Writing ± original draft: Yoko Ito, Hong Wei Chu. Writing ± review & editing: William Janssen, James Finigan, Rangnath ... Mishra, Hong Wei Chu. 11 / 13 12 / 13 1. Sgalla G , Biffi A , Richeldi L . Idiopathic pulmonary fibrosis: Diagnosis, epidemiology and natural history . Respirology . 2016 ; 21 ( 3 ): 427 ± 37 . https
Background In type 2 diabetes, free fatty acids (FFA) accumulate in microvascular cells, but the phenotypic consequences of FFA accumulation in the microvasculature are incompletely understood. Here we investigated whether saturated FFA induce apoptosis in human microvascular mesangial cells and analyzed the signaling pathways involved. Methods Saturated and unsaturated FFA...
In type 2 diabetes, free fatty acids (FFA) accumulate in microvascular cells, but the phenotypic consequences of FFA accumulation in the microvasculature are incompletely understood. Here we investigated whether saturated FFA induce apoptosis in human microvascular mesangial cells and analyzed the signaling pathways involved. Saturated and unsaturated FFA-albumin complexes were...
Motivation: Non–small-cell lung cancer (NSCLC) is the leading cause of cancer death in the United States. Targeted tyrosine kinase inhibitors (TKIs) directed against the epidermal growth factor receptor (EGFR) have been widely and successfully used in treating NSCLC patients with activating EGFR mutations. Unfortunately, the duration of response is short-lived, and all patients...