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Proteomics of Staphylococcus aureus biofilm matrix in a rat model of orthopedic implant-associated infection

, Ravi Kr. Gupta, Chia Y. Lee. Data curation: Mei G. Lei, Ravi Kr. Gupta, Chia Y. Lee. Formal analysis: Mei G. Lei, Ravi Kr. Gupta, Chia Y. Lee. Funding acquisition: Mei G. Lei, Chia Y. Lee ... . Investigation: Mei G. Lei, Ravi Kr. Gupta, Chia Y. Lee. Methodology: Mei G. Lei, Ravi Kr. Gupta, Chia Y. Lee. Project administration: Chia Y. Lee. Resources: Chia Y. Lee. Supervision: Chia Y. Lee. Validation

MgrA Activates Expression of Capsule Genes, but Not the α-Toxin Gene in Experimental Staphylococcus aureus Endocarditis

Background. Staphylococcus aureus produces numerous virulence factors but little is known about their in vivo regulation during an infection. Methods. The production of capsule and α-toxin, and the expression of their respective genes, cap5 and hla, were analyzed by comparing CYL11481 (derivative of Newman) and its isogenic regulatory mutants in vitro. The temporal expression of...