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Search: authors:"Rency S. Varghese"

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Identification of race-associated metabolite biomarkers for hepatocellular carcinoma in patients with liver cirrhosis and hepatitis C virus infection

Institute of the National Institutes of Health under Award Numbers U01CA185188 and R01CA143420. Author Contributions Conceptualization: Habtom W. Ressom. Data curation: Cristina Di Poto, Shisi He, Rency S ... . Resources: Abdullah Karabala, Mesfin Redi, Hassen Mamo, Amol S. Rangnekar, Thomas M. Fishbein, Alexander H. Kroemer. Supervision: Cristina Di Poto. Validation: Cristina Di Poto. Visualization: Rency S

GC-MS Based Plasma Metabolomics for Identification of Candidate Biomarkers for Hepatocellular Carcinoma in Egyptian Cohort

This study evaluates changes in metabolite levels in hepatocellular carcinoma (HCC) cases vs. patients with liver cirrhosis by analysis of human blood plasma using gas chromatography coupled with mass spectrometry (GC-MS). Untargeted metabolomic analysis of plasma samples from participants recruited in Egypt was performed using two GC-MS platforms: a GC coupled to single quadruple ...

Ion annotation-assisted analysis of LC-MS based metabolomic experiment

Background Analysis of multiple LC-MS based metabolomic studies is carried out to determine overlaps and differences among various experiments. For example, in large metabolic biomarker discovery studies involving hundreds of samples, it may be necessary to conduct multiple experiments, each involving a subset of the samples due to technical limitations. The ions selected from each ...

Using a spike-in experiment to evaluate analysis of LC-MS data

Background Recent advances in liquid chromatography-mass spectrometry (LC-MS) technology have led to more effective approaches for measuring changes in peptide/protein abundances in biological samples. Label-free LC-MS methods have been used for extraction of quantitative information and for detection of differentially abundant peptides/proteins. However, difference detection by ...

Candidate markers for the detection of hepatocellular carcinoma in low-molecular weight fraction of serum

Hepatocellular carcinoma (HCC) represents an important public health problem in Egypt where up to 90% of HCC cases are attributable to hepatitis C viral (HCV) infection. Serum alpha-fetoprotein is elevated in only ∼60% of HCC patients. The development of effective markers for the detection of HCC could have an impact on cancer mortality and significant public health implications ...

Analysis of mass spectral serum profiles for biomarker selection

Motivation: Mass spectrometric profiles of peptides and proteins obtained by current technologies are characterized by complex spectra, high dimensionality and substantial noise. These characteristics generate challenges in the discovery of proteins and protein-profiles that distinguish disease states, e.g. cancer patients from healthy individuals. We present low-level methods for ...