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Search: authors:"Richa Pandey"

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Pharmacokinetics of a New Oral Vitamin D Receptor Activator (2-Methylene-19-Nor-(20S)-1α,25-Dihydroxyvitamin D3) in Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism on Hemodialysis

Background 2-Methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (DP001 or 2MD) is a novel, potent 1α-hydroxylated vitamin D analog that binds to the vitamin D receptor and suppresses parathyroid hormone synthesis and secretion with potential for an improved safety profile compared to existing active vitamin D analogs. The purpose of this study was to evaluate the pharmacokinetics...

Detection and Mapping of QTLs Affecting Contents of Pharmaceutical Alkaloids in Leaf and Root of Catharanthus roseus

Catharanthus roseus leaves and roots hyper-accumulate the terpenoid indole alkaloids, which are required for the economic production of pharmaceutical molecules vindoline (V), catharanthine (C), vinblastine (VB), vincristine (VC), ajmalicine (A) and serpentine (S). For developing marker-assisted selection (MAS) breeding in C. roseus, the objectives of the present study were: (a...