Wiese, Marie Schluterman Burdine. Formal analysis: Ara Kim Wiese, Marie Schluterman Burdine, Lyle J. Burdine. Funding acquisition: Richard H. Turnage, Alan J. Tackett, Lyle J. Burdine. Investigation: Ara
Constitutive activation of the Rearranged during Transfection (RET) proto-oncogene leads to the development of MEN2A medullary thyroid cancer (MTC). The relatively clear genotype/phenotype relationship seen with RET mutations and the development of MEN2A is unusual in the fact that a single gene activity can drive the progression towards metastatic disease. Despite knowing the...
