Lower limb muscle atrophy is often observed in critically ill patients. Although upper limb muscles can undergo atrophy, it remains unclear how this atrophy is associated with clinical outcomes. We hypothesized that this atrophy is associated with mortality and impairments in physical function. In this two-center prospective observational study, we included adult patients who...
Skeletal muscle atrophy commonly occurs in critically ill patients, and decreased muscle mass is associated with worse clinical outcomes. Muscle mass can be assessed using various tools, including ultrasound and bioelectrical impedance analysis (BIA). However, the effectiveness of muscle mass monitoring is unclear in critically ill patients. This study was conducted to compare...
New insights into the genetic basis of infertility Thejaswini Venkatesh,1 Padmanaban S Suresh,2 Rie Tsutsumi3 1Institute for Stem Cell Biology and Regenerative Medicine, National Centre for Biological Sciences, Bangalore, 2Centre for Biomedical Research, VIT University, Vellore, India; 3University of Tokushima, Institute of Health Bioscience, Department of Public Health and...
Objective Enhanced recovery after surgery is increasingly desired nowadays, and preoperative nutrient intake may be beneficial for this purpose. In this study, we investigated whether the intake of preoperative carbohydrate with amino acid (ONS) solution can improve starvation status and lipid catabolism before the induction of anesthesia. Methods This randomized, prospective...
Leptin is a key regulator of energy intake and expenditure. This peptide hormone is expressed in mouse white adipose tissue, but hardly expressed in 3T3-L1 adipocytes. Using bisulfite sequencing, we found that CpG islands in the leptin promoter are highly methylated in 3T3-L1cells. 5-azacytidine, an inhibitor of DNA methyltransferase, markedly increased leptin expression as pre...
Background Exendin-4, an exogenous glucagon-like peptide-1 receptor (GLP-1R) agonist, protects the heart from ischemia/reperfusion injury. However, the mechanisms for this protection are poorly understood. Caveolae, sarcolemmal invaginations, and caveolins, scaffolding proteins in caveolae, localize molecules involved in cardiac protection. We tested the hypothesis that caveolae...
Exendin-4, an exogenous glucagon-like peptide-1 receptor (GLP-1R) agonist, protects the heart from ischemia/reperfusion injury. However, the mechanisms for this protection are poorly understood. Caveolae, sarcolemmal invaginations, and caveolins, scaffolding proteins in caveolae, localize molecules involved in cardiac protection. We tested the hypothesis that caveolae and...
Anti-cancer pharmaceuticals frequently have adverse side effects on patients such as gastrointestinal involvement limiting their clinical applications. These effects may be controlled by nutritional interventions, however, there are few studies that have shown any mechanistic effects. In this study, we examined effects of diet enhanced with eicosapentaenoic acid (EPA) and...
in treating metabolic and age-related diseases. Additional file 1: Table S1. Supplemental table Primer sequences. Competing interests All authors (Rie Tsutsumi, Tomomi Yoshida, Yoshitaka Nii, Naoki
and Sayaka Sasaga for their technical support. Funding Rie Tsutsumi: Funding was provided by the Japan Society for the Promotion of Sciences, Tokyo JSPS KAKENHI 24650489. Tohru Sakai: Funding was ... 12986_2014_631_MOESM9_ESM.tif Authors’ original file for figure 8 12986_2014_631_MOESM10_ESM.tif Authors’ original file for figure 9 Competing interests All authors (Rie Tsutsumi, Tomomi Yoshida, Yoshitaka Nii
