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Termination of pregnancy and sterilisation in women with childhood-onset type 1 diabetes

Aims/hypothesis The aim of this study was to explore the association between type 1 diabetes and reproductive health indicators in women, focusing on termination of pregnancy and sterilisation. Methods We conducted a registry-based cohort study involving 2281 women with childhood-onset type 1 diabetes, matched for age and birthplace with women without diabetes: two control...

Low-molecular-weight heparin for prevention of placenta-mediated pregnancy complications: protocol for a systematic review and individual patient data meta-analysis (AFFIRM)

Bates David Petroff Dick Bezemer 1 Marion E van Hoorn 1 Carolien NH Abheiden 1 Annalisa Perna Paulien de Jong Risto Kaaja 0 The Ottawa Hospital, Centre for Practice-Changing Research , 501 Smyth Road, Box

Do mitochondrial mutations cause recurrent miscarriage?

The cause of recurrent miscarriage (RM) can be identified in ∼50% of cases, whereas in others, unknown genetic factors are actively being sought. As mitochondrial functions, and therefore also the mitochondrial genome [mitochondrial DNA (mtDNA)], have an important role in human development, through ATP production and participation in apoptosis, we aimed to study the role of mtDNA...

Clinical cure of severe, early onset preeclampsia with low molecular weight heparin therapy in primigravida with hyperreactio luteinalis and thrombophilia

Tiitinen 0 Veli-Matti Ulander 0 Risto Kaaja 0 0 Department of Obstetrics and Gynaecology, Helsinki University Central Hospital , PO Box 140, FIN-00290 HUS Helsinki , Finland 1To whom correspondence should

Progression of Retinopathy During Pregnancy in Type 1 Diabetic Women Treated With Insulin Lispro

OBJECTIVE— To evaluate the progression of retinopathy during pregnancy and postpartum in (insulin-dependent) women with type 1 diabetes treated with insulin lispro or with regular human insulin. RESEARCH DESIGN AND METHODS— A prospective open study of 69 pregnant women with diabetes was performed. A total of 36 of the women were treated with insulin lispro (lispro group) and 33...

Variations of the Amnionless gene in recurrent spontaneous abortions

Recurrent spontaneous abortions (RSA) are estimated to affect 0.5–1% of couples trying to have a child. The causes of RSA are unknown in the majority of cases. This study aimed to determine whether homozygous mutations in the AMN gene in a fetus cause spontaneous abortions in humans, as they are known to cause spontaneous abortions in mice. The study was conducted by screening 40...