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Low-molecular-weight heparin for prevention of placenta-mediated pregnancy complications: protocol for a systematic review and individual patient data meta-analysis (AFFIRM)

Bates David Petroff Dick Bezemer 1 Marion E van Hoorn 1 Carolien NH Abheiden 1 Annalisa Perna Paulien de Jong Risto Kaaja 0 The Ottawa Hospital, Centre for Practice-Changing Research , 501 Smyth Road, Box

Low-molecular-weight heparin for prevention of placenta-mediated pregnancy complications: protocol for a systematic review and individual patient data meta-analysis (AFFIRM)

Placenta-mediated pregnancy complications include pre-eclampsia, late pregnancy loss, placental abruption, and the small-for-gestational age newborn. They are leading causes of maternal, fetal, and neonatal morbidity and mortality in developed nations. Women who have experienced these complications are at an elevated risk of recurrence in subsequent pregnancies. However, despite...