People with cancer face an elevated risk of infection and severe sequelae from COVID-19. Dexamethasone is commonly used for antiemetic prophylaxis with systemic therapy for cancer. However, dexamethasone is associated with increased risk of viral and respiratory infections, and causes lymphopenia, which is associated with worse outcomes during COVID-19 infections. Our purpose was...
Figueroa Grainne M. O'Kane Ashton A. Connor Robert E. Denroche Robert C. Grant Jessica McLeod Julie M. Wilson Gun Ho Jang Amy Zhang Sheng-Ben Liang Ayelet Borgida Dianne Chadwick Sangeetha Kalimuthu Ilinca
We sequenced 11 germline exomes from five families with familial pancreatic cancer (FPC). One proband had a germline nonsense variant in ATM with somatic loss of the variant allele. Another proband had a nonsense variant in PALB2 with somatic loss of the variant allele. Both variants were absent in a relative with FPC. These findings question the causal mechanisms of ATM and...
