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29 papers found.
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Weight change and 15 year mortality: results from the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) cohort study

Studies have reported a higher mortality risk associated with weight loss, particularly in middle-aged and older adults, although some of these studies did find that gaining weight was also associated with an increased mortality risk. We examined changes in weight in relation to mortality in a prospective population-based cohort study of men and women, resident in Norfolk, UK...

Longitudinal association of C-reactive protein and Haemoglobin A1c over 13 years: the European Prospective Investigation into Cancer - Norfolk study

Background Type-2 diabetes is associated with systemic inflammation and higher C-reactive protein (CRP) levels. However, the longitudinal association of CRP and haemoglobin-A1c (HbA1c) has not been described in large prospective studies. Understanding such associations may shed light on the role of inflammation in development of type-2 diabetes and its complications such as...

Flavonoid Intake in European Adults (18 to 64 Years)

Background Flavonoids are a group of phenolic secondary plant metabolites that are ubiquitous in plant-based diets. Data from anthropological, observational and intervention studies have shown that many flavonoids are bioactive. For this reason, there is an increasing interest in investigating the potential health effects of these compounds. The translation of these findings into...

Longitudinal Association of C-Reactive Protein and Lung Function Over 13 Years: The EPIC-Norfolk Study

Kingdom (Sara Ahmadi-Abhari, Stephen Kaptoge, Robert N. Luben, Kay-Tee Khaw); and Medical Research Council Epidemiology Unit, Institute of Metabolic Sciences, Cambridge, United Kingdom (Nicholas J. Wareham

Dietary dairy product intake and incident type 2 diabetes: a prospective study using dietary data from a 7-day food diary

Laura M. O'Connor Marleen A. H. Lentjes Robert N. Luben Kay-Tee Khaw Nicholas J. Wareham Nita G. Forouhi 0 ) MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of

Associations with intraocular pressure across Europe: The European Eye Epidemiology (E3) Consortium

Raised intraocular pressure (IOP) is the most important risk factor for developing glaucoma, the second commonest cause of blindness globally. Understanding associations with IOP and variations in IOP between countries may teach us about mechanisms underlying glaucoma. We examined cross-sectional associations with IOP in 43,500 European adults from 12 cohort studies belonging to...

A Prospective Study of the Association Between Quantity and Variety of Fruit and Vegetable Intake and Incident Type 2 Diabetes

ANDREW J. COOPER MPHIL STEPHEN J. SHARP MSC MARLEEN A.H. LENTJES MSC ROBERT N. LUBEN BSC KAY-TEE KHAW PHD NICHOLAS J. WAREHAM PHD NITA G. FOROUHI FFPH PHD E p i d e m i o l o g y / H e a l t h

Incidence of Type 2 Diabetes Using Proposed HbA1c Diagnostic Criteria in the European Prospective Investigation of Cancer–Norfolk Cohort: Implications for preventive strategies

PARINYA CHAMNAN REBECCA K. SIMMONS PHD NITA G. FOROUHI ROBERT N. LUBEN BSC KAY-TEE KHAW PHD NICHOLAS J. WAREHAM PHD SIMON J. GRIFFIN DM E p i d e m i o l o g y / H e a l t h OBJECTIVE-To evaluate

A Latent Variable Partial Least Squares Path Modeling Approach to Regional Association and Polygenic Effect with Applications to a Human Obesity Study

Genetic association studies are now routinely used to identify single nucleotide polymorphisms (SNPs) linked with human diseases or traits through single SNP-single trait tests. Here we introduced partial least squares path modeling (PLSPM) for association between single or multiple SNPs and a latent trait that can involve single or multiple correlated measurement(s). Furthermore...

Prevalence of refractive error in Europe: the European Eye Epidemiology (E3) Consortium

To estimate the prevalence of refractive error in adults across Europe. Refractive data (mean spherical equivalent) collected between 1990 and 2013 from fifteen population-based cohort and cross-sectional studies of the European Eye Epidemiology (E3) Consortium were combined in a random effects meta-analysis stratified by 5-year age intervals and gender. Participants were...

RAD51B in Familial Breast Cancer

Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer. The aim of this study was to investigate the role of RAD51B variants in breast cancer predisposition, particularly in the context of familial breast cancer in Finland. We sequenced the...

Accuracy of death certification and hospital record linkage for identification of incident stroke

Background There is little information on the validity of using record linkage with routinely collected data for case ascertainment of stroke in large population-based studies in the UK. We examined the accuracy of these routine record linkage approaches for identifying incident stroke cases in a large UK population-based study, the European Prospective Investigation into Cancer...

Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

Background The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the PI3K/AKT signalling pathway. This study investigates the prevalence of loss of PTEN expression and mutations in both PTEN and PIK3CA in colorectal cancers (CRC) and their associations with tumour clinicopathological...

Physical Activity Attenuates the Genetic Predisposition to Obesity in 20,000 Men and Women from EPIC-Norfolk Prospective Population Study

Shengxu Li and colleagues use data from a large prospective observational cohort to examine the extent to which a genetic predisposition toward obesity may be modified by living a physically active lifestyle.

Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study

Background BRAF and K-ras proto-oncogenes encode components of the ERK signalling pathway and are frequently mutated in colorectal cancer. This study investigates the associations between BRAF and K-ras mutations and clinicopathological, lifestyle and dietary factors in colorectal cancers. Methods 186 adenocarcinomas and 16 adenomas from the EPIC Norfolk study were tested for...

Association Between Type of Dietary Fish and Seafood Intake and the Risk of Incident Type 2 Diabetes: The European Prospective Investigation of Cancer (EPIC)-Norfolk cohort study

PINAL S. PATEL MPHIL STEPHEN J. SHARP MSC ROBERT N. LUBEN BSC KAY-TEE KHAW SHEILA A. BINGHAM PHD NICHOLAS J. WAREHAM NITA G. FOROUHI FFPH E p i d e m i o l o g y / H e a l t h OBJECTIVE - To

Lifestyle factors and p53 mutation patterns in colorectal cancer patients in the EPIC-Norfolk study

The tumour suppressor p53 is one of the most commonly altered genes in colorectal cancer (CRC) development. Genetic alterations in p53 may therefore be associated with postulated lifestyle risk factors for CRC, such as red meat consumption. In the European Prospective Investigation into Cancer and Nutrition-Norfolk study, we examined whether detailed estimates of dietary and...

Energy Intake at Breakfast and Weight Change: Prospective Study of 6,764 Middle-aged Men and Women

To investigate the association between percentage of total daily energy intake consumed at breakfast and weight change in middle-aged men and women, the authors analyzed data from a prospective population-based cohort study from Norfolk, United Kingdom. Participants were 6,764 men and women aged 40–75 years at baseline (1993–1997). Participants completed a 7-day food diary at...

Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk

Introduction Certain rare, familial mutations in the ATM, BRCA1, BRCA2, CHEK2 or TP53 genes increase susceptibility to breast cancer but it has not, until now, been clear whether common polymorphic variants in the same genes also increase risk. Methods We have attempted a comprehensive, single nucleotide polymorphism (SNP)- and haplotype-tagging association study on each of these...

Socioeconomic position and risk of short-term weight gain: Prospective study of 14,619 middle-aged men and women

Background The association between socioeconomic position in middle age and risk of subsequent, short-term weight gain is unknown. We therefore assessed this association in a prospective population based cohort study in Norfolk, UK. Methods We analysed data on 14,619 middle-aged men and women (aged between 40–75 at baseline) with repeated objective measures of weight and height...