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Modelling community-control strategies to protect hospital resources during an influenza pandemic in Ottawa, Canada

Background A novel influenza virus has emerged to produce a global pandemic four times in the past one hundred years, resulting in millions of infections, hospitalizations and deaths. There is substantial uncertainty about when, where and how the next influenza pandemic will occur. Methods We developed a novel mathematical model to chart the evolution of an influenza pandemic. We...

A Spy Among Friends: Kim Philby and the Great Betrayal. By Ben Macintyre, NY: Crown, 2014

, for the core of this book, the rampant institutional failure makes it such an important read. Robert Smith, American Public University System ... Smith 0 0 American Public University System Recommended Citation - Follow this and additional works at: pp. 117-118 A Spy Among Friends by Ben Macintyre is the story

Targeted next generation sequencing identifies novel NOTCH3 gene mutations in CADASIL diagnostics patients

Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic, hereditary, small vessel disease of the brain causing stroke and vascular dementia in adults. CADASIL has previously been shown to be caused by varying mutations in the NOTCH3 gene. The disorder is often misdiagnosed due to its significant clinical...


CROWDFUNDING M. Nesij Huvaj, Suffolk University, USA Robert Smith, Suffolk University, USA Aron Darmody, Suffolk University, USA Principal Topic Crowdfunding has emerged as a novel and effective way to fund

Knee Cartilage Thickness, T1ρ and T2 Relaxation Time Are Related to Articular Cartilage Loading in Healthy Adults

Cartilage is responsive to the loading imposed during cyclic routine activities. However, the local relation between cartilage in terms of thickness distribution and biochemical composition and the local contact pressure during walking has not been established. The objective of this study was to evaluate the relation between cartilage thickness, proteoglycan and collagen...

Magnetic Resonance Imaging of Cartilage Contact and Bound Water in ACL-Deficient and ACL Reconstructed Knees

Objectives: Osteoarthritis (OA) is common following ACL-reconstructive (ACLR) surgery (6). The cause of early OA is not understood, but theories have focused on osteochondral damage at the time of injury (2) and abnormal joint mechanics following surgical repair (7). In this study, we investigate the inter-relationship of cartilage mechanics and biomarkers of OA in both ACL...

Unearthing the transition rates between photoreceptor conformers

Background Obtaining accurate estimates of biological or enzymatic reaction rates is critical in understanding the design principles of a network and how biological processes can be experimentally manipulated on demand. In many cases experimental limitations mean that some enzymatic rates cannot be measured directly, requiring mathematical algorithms to estimate them. Here, we...

Genetic association analysis of miRNA SNPs implicates MIR145 in breast cancer susceptibility

Background MicroRNAs (miRNAs) are important small non-coding RNA molecules that regulate gene expression in cellular processes related to the pathogenesis of cancer. Genetic variation in miRNA genes could impact their synthesis and cellular effects and single nucleotide polymorphisms (SNPs) are one example of genetic variants studied in relation to breast cancer. Studies aimed at...

Mentoring and Perpetuating the Entrepreneurial Spirit within Family Business by Telling Contingent Stories

Family businesses do not perpetuate themselves. Entrepreneurs must nurture and propagate the values that led to the creation of the very thing most precious to them—their business.This of course depends on stability. Nor do these cherished values propagate themselves. To be made meaningful for others, and for future generations, family experiences, values, and achievements must...

Demand response: a strategy to address residential air-conditioning peak load in Australia

source are credited. Author Biographies Robert SMITH is a senior engineer with Ausgrid, Sydney, Australia. His research interest includes energy management and grid applications. Ke MENG (M’10) obtained

Multipass haemodialysis: a novel dialysis modality

Introduction Most home haemodialysis (HD) modalities are limited to home use since they are based on a single-pass (SP) technique, which requires preparation of large amounts of dialysate. We present a new dialysis method, which requires minimal dialysate volumes, continuously recycled during treatment [multipass HD (MPHD)]. Theoretical calculations suggest that MPHD performed...

Redemption Song: Graham v. Florida and the Evolving Eighth Amendment Jurisprudence

Race and Justice at Harvard Law School. ** Of Counsel for the Capital Appeals Project in New Orleans, Louisiana. † Suggested citation: Robert Smith & G. Ben Cohen, Commentary, Redemption Song: Graham v

Simvastatin Inhibits Glucose Metabolism and Legumain Activity in Human Myotubes

Simvastatin, a HMG-CoA reductase inhibitor, is prescribed worldwide to patients with hypercholesterolemia. Although simvastatin is well tolerated, side effects like myotoxicity are reported. The mechanism for statin-induced myotoxicity is still poorly understood. Reports have suggested impaired mitochondrial dysfunction as a contributor to the observed myotoxicity. In this regard...

Chronic tophaceous gout presenting as acute arthritis during an acute illness: a case report

Abhijeet Dhoble 0 Vijay Balakrishnan 0 Robert Smith 0 0 Address: Department of Internal Medicine, Michigan State University , East Lansing, Michigan , USA Background: Gout is a metabolic disease

Primary hepatic lymphoma presenting as fulminant hepatic failure with hyperferritinemia: A case report

Haider - Robert Smith - Sharif Khan - Corresponding author 0 Department of Hematology and Oncology, Geisinger Medical Center , Danville, PA 17821 , USA 1 Department of Gastroenterology and Hepatology

Radiographers supporting radiologists in the interpretation of screening mammography: a viable strategy to meet the shortage in the number of radiologists

Background An alternative approach to the traditional model of radiologists interpreting screening mammography is necessary due to the shortage of radiologists to interpret screening mammograms in many countries. Methods We evaluated the performance of 15 Mexican radiographers, also known as radiologic technologists, in the interpretation of screening mammography after a 6 months...