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Tapentadol Extended Release in the Treatment of Severe Chronic Low Back Pain and Osteoarthritis Pain

responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. Disclosures. Joseph V. Pergolizzi, Robert Taylor, Jr, Jo Ann LeQuang, Robert B. Raffa, and


: - O OCEAN Robert Taylor Spring 2014

Big Sur

Big Sur Robert Taylor 0 Recommended Citation 0 This Visual Art is brought to you for free and open access by ScholarWorks at University of Montana. It has been accepted for inclusion in The Oval by ... , USA Follow this and additional works at: - BIG SUR Robert Taylor The Oval | Staff Issue

Real Women

Real W o m en Robert Taylor 0 Recommended Citation 0 This Prose is brought to you for free and open access by ScholarWorks at University of Montana. It has been accepted for inclusion in The Oval by

Ray Price

Ray Price Robert Taylor 0 0 This Visual Art is brought to you for free and open access by ScholarWorks at University of Montana. It has been accepted for inclusion in The Oval by , USA Recommended ... Citation - Let us know how access to this document benefits you. Follow this and additional works at: Part of the Creative Writing Commons RAY PRICE Robert Taylor

Influence of TP53 and CDH1 genes in hepatocellular cancer spheroid formation and culture: a model system to understand cancer cell growth mechanics

Background Spheroid based culture methods are gaining prominence to elucidate the role of the microenvironment in liver carcinogenesis. Additionally, the phenomenon of epithelial-mesenchymal transition also plays an important role in determining the metastatic potential of liver cancer. Tumor spheroids are thus important models to understand the basic biology of liver cancer...

Model estimates of the burden of outpatient visits attributable to influenza in the United States

by the GSK group of companies. Robert Taylor, Roger Lustig, Laurel Edelman and Gerardo Chowell report having received consulting fees from Sage Analytica LLC, which were paid by the GSK group of ... companies to perform this study. Robert Taylor has an ownership interest in Sage Analytica, a consultancy in epidemiology and bioinformatics. Gerardo Chowell is a member of the BMC Infectious Disease

China’s Evolving Human Resource Management: The Impact of Global Networks

Robert Taylor 0 0 R. Taylor (&) School of East Asian Studies, University of Sheffield , Sheffield, UK China's increasing participation in global business networks through both inward and outward

Modelling estimates of age-specific influenza-related hospitalisation and mortality in the United Kingdom

Background Influenza is rarely confirmed with laboratory testing and accurate assessment of the overall burden of influenza is difficult. We used statistical modelling methods to generate updated, granular estimates of the number/rate of influenza-attributable hospitalisations and deaths in the United Kingdom. Such data are needed on a continuing basis to inform on cost-benefit...

The Potential Role of an Extended-Release, Abuse-Deterrent Oxycodone/Acetaminophen Fixed-Dose Combination Product for the Treatment of Acute Pain

Acute pain, prevalent as part of postoperative and traumatic pain, is often sub-optimally or inadequately treated. Fixed-dose combination analgesic products that combine a reduced amount of opioid with a nonopioid analgesic such as acetaminophen (paracetamol) in a single tablet offer potential pharmacodynamic and/or pharmacokinetic benefits, and may also result in an opioid...

Small-Scale Assays for Studying Dissolution of Pharmaceutical Cocrystals for Oral Administration

The purpose of this study was to better understand the dissolution properties and precipitation behavior of pharmaceutical cocrystals of poorly soluble drugs for the potential for oral administration based on a small-scale dissolution assay. Carbamazepine and indomethacin cocrystals with saccharin and nicotinamide as coformers were prepared with the sonic slurry method...

Modelling estimates of the burden of Respiratory Syncytial virus infection in adults and the elderly in the United Kingdom

consulting fees from Sage Analytica, LLC to conduct part of the analytical work described in this paper as well as outside the submitted work. Roger Lustig is an employee of Sage Analytica, LLC. Robert Taylor

Fixed dose artesunate amodiaquine – a phase IIb, randomized comparative trial with non-fixed artesunate amodiaquine

Background Pharmacokinetic (PK) and pharmacodynamic (PD) data are limited for artesunate (AS) and amodiaquine (AQ) in uncomplicated Plasmodium falciparum. Methods From 2007-8, 54 P. falciparum-infected, Kenyan adults were assigned randomly fixed dose (FD) ASAQ (n = 26) or non-fixed (NF) ASAQ (n = 28). Total doses were 600 mg AS (both arms) + 1,620 mg (FD) or 1,836 mg (NF)AQ...

Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial—PROSPECT: a pilot trial

Background Probiotics are live microorganisms that may confer health benefits when ingested. Randomized trials suggest that probiotics significantly decrease the incidence of ventilator-associated pneumonia (VAP) and the overall incidence of infection in critically ill patients. However, these studies are small, largely single-center, and at risk of bias. The aim of the PROSPECT...

Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function

Activation of the nuclear hormone receptor, PPARγ, with pharmacological agonists promotes a contractile vascular smooth muscle cell phenotype and reduces oxidative stress and cell proliferation, particularly under pathological conditions including vascular injury, restenosis, and atherosclerosis. However, pharmacological agonists activate both PPARγ-dependent and -independent...

Biomechanics and Inflammation in Atherosclerotic Plaque Erosion and Plaque Rupture: Implications for Cardiovascular Events in Women

Merck. Ian Campbell, Jonathan Suever, Lucas Timmins, Alessandro Veneziani, Raymond Vito, and W. Robert Taylor have no conflicts to declare. This does not alter the authors adherence to PLOS ONE policies

Use of the ODD-Luciferase Transgene for the Non-Invasive Imaging of Spontaneous Tumors in Mice

Background In humans, imaging of tumors provides rapid, accurate assessment of tumor growth and location. In laboratory animals, however, the imaging of spontaneously occurring tumors continues to pose many technical and logistical problems. Recently a mouse model was generated in which a chimeric protein consisting of HIF-1α oxygen-dependent degradation domain (ODD) fused to...

Mercury in bats from the northeastern United States

This study examines mercury exposure in bats across the northeast U.S. from 2005 to 2009. We collected 1,481 fur and 681 blood samples from 8 states and analyzed them for total Hg. A subset (n = 20) are also analyzed for methylmercury (MeHg). Ten species of bats from the northeast U.S. are represented in this study of which two are protected by the Endangered Species Act (ESA...

Surgery versus Active Monitoring in Intermittent Exotropia (SamExo): study protocol for a pilot randomised controlled trial

Deborah Buck 0 Elaine McColl Christine J Powell Jing Shen John Sloper Nick Steen Robert Taylor Peter Tiffin Luke Vale Michael P Clarke 0 Institute of Neuroscience, c/o Clinical Trials Unit, Medical