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Search: authors:"Robert W. Luebke"

5 papers found.
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Suppression of Humoral Immunity by Perfluorooctanoic Acid is Independent of Elevated Serum Corticosterone Concentration in Mice

The T-cell–dependent antibody response is suppressed in mice exposed to 3.75, 7.5, 15, and 30 mg PFOA (perfluorooctanoic acid)/kg body weight (bw). Reduced bw accompanied immunosuppression at 15 and 30 mg/kg. We investigated the hypothesis that the observed immunosuppression is secondary to elevated serum corticosterone levels by assessing immune function in adrenalectomized (adx...

Serum Supplementation Modulates the Effects of Dibutyltin on Human Natural Killer Cell Function

Natural killer (NK) cells are a subset of lymphocytes capable of killing tumor cells, virally infected cells and antibody-coated cells. Dibutyltin (DBT) dichloride is an organotin used as a stabilizer in polyvinylchloride (PVC) plastics and as a deworming product in poultry. DBT may leach from PVC water supply pipes and therefore poses a potential risk to human health. We...

Immunotoxicogenomics: The Potential of Genomics Technology in the Immunotoxicity Risk Assessment Process

Evaluation of xenobiotic-induced changes in gene expression as a method to identify and classify potential toxicants is being pursued by industry and regulatory agencies worldwide. A workshop was held at the Research Triangle Park campus of the Environmental Protection Agency to discuss the current state-of-the-science of “immunotoxicogenomics” and to explore the potential role...

Mortality in Dioxin-Exposed Mice Infected with Influenza: Mitochondrial Toxicity (Reye's-Like Syndrome) Versus Enhanced Inflammation as the Mode of Action

Increased mortality following influenza A infection was reported in B6C3F1 mice exposed to a low (0.01 μg/kg) dose of dioxin. However, mortality was not associated with increased viral load and antibody titers to the virus were not decreased at doses of TCDD ≤ 10 μg/kg, suggesting that viral overgrowth, secondary to immunosuppression, was not the proximate cause of death. We...

Aquatic Pollution-Induced Immunotoxicity in Wildlife Species1

The potential for chemicals to adversely affect human immunologic health has traditionally been evaluated in rodents, under laboratory conditions. These laboratory studies have generated valuable hazard identification and immunotoxicologic mechanism data; however, genetically diverse populations exposed in the wild may better reflect both human exposure conditions and may provide...