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Error correction of next-generation sequencing data and reliable estimation of HIV quasispecies

Next-generation sequencing technologies can be used to analyse genetically heterogeneous samples at unprecedented detail. The high coverage achievable with these methods enables the detection of many low-frequency variants. However, sequencing errors complicate the analysis of mixed populations and result in inflated estimates of genetic diversity. We developed a probabilistic ...

Genotypic tropism testing by massively parallel sequencing: qualitative and quantitative analysis

Background Inferring viral tropism from genotype is a fast and inexpensive alternative to phenotypic testing. While being highly predictive when performed on clonal samples, sensitivity of predicting CXCR4-using (X4) variants drops substantially in clinical isolates. This is mainly attributed to minor variants not detected by standard bulk-sequencing. Massively parallel sequencing ...

The reliability of the Bad Sobernheim Stress Questionnaire (BSSQbrace) in adolescents with scoliosis during brace treatment

Background A new instrument to assess stress scoliosis patients have whilst wearing their brace has been developed. Aim of this study was to test the reliability of this new instrument. Methods Eight questions are provided focussing on this topic only, including two questions to test the credibility. A max. score of 24 can be achieved (from 0 for most stress to 24 for least ...

Reliability of the Bad Sobernheim Stress Questionnaire (BSSQbrace)

:// Sobernheim Stress Questionnaire Rolf Klein, Carola Stephan and Hans Address: Asklepios Katharina Schroth Spinal Deformities Rehabilitation Centre, Korczakstrasse 2; D