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125 papers found.
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Polymorphisms at microRNA binding sites of Ara-C and anthracyclines-metabolic pathway genes are associated with outcome of acute myeloid leukemia patients

Gene polymorphisms at microRNA-binding sites (poly-miRTS) may affect gene transcription and expression through miRNA regulation, which is associated with cancer susceptibility, sensitivity to chemotherapy and prognosis. This study investigated the association between poly-miRTS of Ara-C/anthracycline metabolic pathways genes and the outcome of acute myeloid leukemia (AML) in ...

Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain

, Soichiro Kitamura, Sho Moriguchi, Manabu Kubota, Ming-Rong Zhang. 12 / 15 Formal analysis: Tatsuya Ishii, Yasuyuki Kimura. Investigation: Tatsuya Ishii, Keisuke Takahata, Soichiro Kitamura, Sho Moriguchi ... , Manabu Kubota, Ming-Rong Zhang. Methodology: Tatsuya Ishii, Yasuyuki Kimura. Project administration: Makoto Higuchi. Supervision: Yasuyuki Kimura, Masanori Ichise, Makiko Yamada, Makoto Higuchi

Double JPEG compression forensics based on a convolutional neural network

Double JPEG compression detection has received considerable attention in blind image forensics. However, only few techniques can provide automatic localization. To address this challenge, this paper proposes a double JPEG compression detection algorithm based on a convolutional neural network (CNN). The CNN is designed to classify histograms of discrete cosine transform (DCT) ...

Effects of water avoidance stress on peripheral and central responses during bladder filling in the rat: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome (MAPP) research network study

analysis: Zhuo Wang, Harriet H. Chang, Daniel P. Holschneider. Funding acquisition: Larissa V. Rodriguez. Investigation: Zhuo Wang, Harriet H. Chang, Yunliang Gao, Rong Zhang, Yumei Guo. Methodology: Zhuo ... Wang, Harriet H. Chang, Rong Zhang, Daniel P. Holschneider, Larissa V. Rodriguez. Project administration: Daniel P. Holschneider, Larissa V. Rodriguez. Supervision: Daniel P. Holschneider. Writing

CNN-SVM for Microvascular Morphological Type Recognition with Data Augmentation

, China 2 & Rong Zhang 3 Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University , Hefei 230022 , China This paper focuses on the problem of feature extraction and the

Genes Related to Oxytocin and Arginine-Vasopressin Pathways: Associations with Autism Spectrum Disorders

University , Beijing 100191 , China 2 & Rong Zhang 3 Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University , Xiamen ... (OXTR), the oxytocinase/vasopressinase (LNPEP), and ADP-ribosyl cyclase (CD38). Oxytocin; Arginine-vasopressin; Single- nucleotide polymorphisms; Autism spectrum disorder - Rong Zhang and Hong-Feng

The quality changes in fresh frozen plasma of the blood donors at high altitude

Objective According to the international guidelines, fresh frozen plasma (FFP) is unanimously used to treat coagulation disorders. The quality of FFP is critical for the clinical transfusion. Till now, few studies have integratedly evaluated the differences of FFP from blood donors at between high altitude (HA) and low altitude (LA). Besides, there were no special quality standards ...

A human PET study of [11C]HMS011, a potential radioligand for AMPA receptors

Zhang 6 Tetsuya Suhara 1 Makoto Higuchi 1 0 Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology

FNC efficiently inhibits mantle cell lymphoma growth

FNC, 2'-deoxy-2'-β-fluoro-4'-azidocytidine, is a novel cytidine analogue, that has shown strong antiproliferative activity in human lymphoma, lung adenocarcinoma and acute myeloid leukemia. In this study, we investigated the effects of FNC on mantle cell lymphoma (MCL) and the underlying mechanisms. In in vitro experiments, cell viability was detected by the CCK8 assay, and cell ...

First Molecular Characterization of Bovine Leukemia Virus Infections in the Caribbean

Bovine leukemia virus (BLV) is a retrovirus that causes enzootic bovine leucosis. To investigate the presence and genetic variability of BLV in the Caribbean for the first time, we preformed fluorescence resonance energy transfer (FRET)-PCR for the pol of BLV on DNA from whole blood of cattle from Dominica, Montserrat, Nevis and St. Kitts. Standard PCRs with primers for the env ...

Ordering non-bipartite unicyclic graphs with pendant vertices by the least Q-eigenvalue

A unicyclic graph is a connected graph whose number of edges is equal to the number of vertices. Fan et al. (Discrete Math. 313:903-909, 2013 ) and Liu et al. (Electron. J. Linear Algebra 26:333-344, 2013 ) determined, independently, the unique unicyclic graph whose least Q-eigenvalue attains the minimum among all non-bipartite unicyclic graphs of order n with k pendant vertices. ...

Phase field simulation of dendrite growth with boundary heat flux

Lifei Du Rong Zhang Boundary heat flux has a significant effect on solidification behavior and microstructure formation, for it can directly affect the interfacial heat flux and cooling rate during

The Mediating Role of Mental Adjustment in the Relationship between Perceived Stress and Depressive Symptoms in Hematological Cancer Patients: A Cross-Sectional Study

Background Depression is a particularly common psychological disorder that affects cancer patients. Diagnosed with hematological malignancies constitute a serious unpredictable and uncontrollable medical stress situation and patients are susceptible to suffer from depressive symptoms. The aims of the study were to explore the correlation between perceived stress and depressive ...

A Volumetric and Functional Connectivity MRI Study of Brain Arginine-Vasopressin Pathways in Autistic Children

Institute, Peking University , Beijing 100191 , China 2 & Rong Zhang 3 Sunshine Friendship Rehabilitation Centre , Beijing 100085 , China 4 Key Laboratory of Ministry of National Health and Family Planning

Effect of Pregnane X Receptor * 1B genetic polymorphisms on postoperative analgesia with fentanyl in Chinese patients undergoing gynecological surgery

Background The purpose of the study was to investigate the effects of the pregnane X receptor (PXR)*1B polymorphisms on CYP3A4 enzyme activity and postoperative fentanyl consumption in Chinese patients undergoing gynecological surgery. Methods A total of 287 females of Han ethnicity, aged 20 to 50 years old, ASA I or II, scheduled to abdominal total hysterectomy or myomectomy under ...

Effect of Parecoxib as an Adjunct to Patient-Controlled Epidural Analgesia after Abdominal Hysterectomy: A Multicenter, Randomized, Placebo-Controlled Trial

Objective This multicenter, randomized, placebo-controlled study evaluated the efficacy and side effects of parecoxib during patient-controlled epidural analgesia (PCEA) after abdominal hysterectomy. Methods A total of 240 patients who were scheduled for elective abdominal hysterectomy under combined spinal-epidural anesthesia received PCEA plus postoperative intravenous parecoxib ...

A functional link between the co-translational protein translocation pathway and the UPR

Upon endoplasmic reticulum (ER) stress, the transmembrane endoribonuclease Ire1α performs mRNA cleavage reactions to increase the ER folding capacity. It is unclear how the low abundant Ire1α efficiently finds and cleaves the majority of mRNAs at the ER membrane. Here, we reveal that Ire1α forms a complex with the Sec61 translocon to cleave its mRNA substrates. We show that Ire1α's ...

New multiplex real-time PCR approach to detect gene mutations for spinal muscular atrophy

Background Spinal muscular atrophy (SMA) is the most common autosomal recessive disease in children, and the diagnosis is complicated and difficult, especially at early stage. Early diagnosis of SMA is able to improve the outcome of SMA patients. In our study, Real-time PCR was developed to measure the gene mutation or deletion of key genes for SMA and to further analyse ...