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Steroid-induced ocular hypertension in Asian children with severe vernal keratoconjunctivitis

Steroid-induced ocular hypertension in Asian children with severe vernal keratoconjunctivitis Marcus Ang,1 Seng-Ei Ti,1 Raymond Loh,1 Sonal Farzavandi,1 Rongli Zhang,2 Donald Tan,1 Cordelia

RNA Editome in Rhesus Macaque Shaped by Purifying Selection

Understanding of the RNA editing process has been broadened considerably by the next generation sequencing technology; however, several issues regarding this regulatory step remain unresolved – the strategies to accurately delineate the editome, the mechanism by which its profile is maintained, and its evolutionary and functional relevance. Here we report an accurate and...

Hominoid-Specific De Novo Protein-Coding Genes Originating from Long Non-Coding RNAs

Tinkering with pre-existing genes has long been known as a major way to create new genes. Recently, however, motherless protein-coding genes have been found to have emerged de novo from ancestral non-coding DNAs. How these genes originated is not well addressed to date. Here we identified 24 hominoid-specific de novo protein-coding genes with precise origination timing in...

RhesusBase: a knowledgebase for the monkey research community

Although the rhesus macaque is a unique model for the translational study of human diseases, currently its use in biomedical research is still in its infant stage due to error-prone gene structures and limited annotations. Here, we present RhesusBase for the monkey research community (http://www.rhesusbase.org). We performed strand-specific RNA-Seq studies in 10 macaque tissues...