Multiple pathomechanisms triggered by mutant Huntingtin (mHTT) underlie progressive degeneration of dopaminoceptive striatal neurons in Huntington’s disease (HD). The primary cilium is a membrane compartment that functions as a hub for various pathways that are dysregulated in HD, for example, dopamine (DA) receptor transmission and the mechanistic target of rapamycin (mTOR...
Monika Bagi?ska Rosanna parlato W?adys?awa Anna Daniel Irena Nalepa parkinson's disease (pD) is the second most common neurodegenerative disorder and is characterized by motor deficits such as tremor
Grzegorz Kreiner Monika Bagińska Justyna Kuśmierczyk Rosanna Parlato Irena Nalepa OPEN Published: xx xx xxxx Evidence exists that chronic antidepressant therapy enhances CREB levels and activity
strategies. Daniela Merlo Inmaculada Cuchillo-Ibañez Rosanna Parlato Gerhard Rammes
strategies. Daniela Merlo Inmaculada Cuchillo-Ibañez Rosanna Parlato Gerhard Rammes
strategies. Daniela Merlo Inmaculada Cuchillo-Ibañez Rosanna Parlato Gerhard Rammes
Rosanna Parlato 0 Grzegorz Kreiner 0 0 G. Kreiner Department of Brain Biochemistry, Institute of Pharmacology, Polish Academy of Sciences , Smetna 12, 31-343, Cracow, Poland 1 ) Department of
The aim of this study was to investigate whether conditional inactivation of the glucocorticoid receptors (GRs) in noradrenergic neurons affects animal behavior in mice. Selective ablation of GRs in the noradrenergic system was achieved using the Cre/loxP approach. We crossed transgenic mice expressing the Cre recombinase under the dopamine beta-hydroxylase (DBH) promoter with...
Acute striatal lesions increase proliferation in the subventricular zone (SVZ) and induce migration of SVZ neuroblasts to the striatum. However, the potential of these cells to replace acutely degenerated neurons is controversial. The possible contribution of parenchymal progenitors to striatal lesion-induced neurogenesis has been poorly explored. Here, we present a detailed...
Schutzl 0 Rosanna Parlato 0 0 10epartment of Molecular Biology of the Cell I and 20epartment of Molecular Biology of the Cell II, German Cancer Research Center , Heidelberg , Germany; 30epartment of Brain
Background Dopamine-activated signaling regulates locomotor and emotional responses and alterations in dopamine-signaling are responsible of several psychomotor disorders. In order to identify specific functions of these pathways, the Cre/loxP system has been used. Here, we describe the generation and the characterization of a transgenic mouse line expressing the Cre recombinase...
Dopamine-activated signaling regulates locomotor and emotional responses and alterations in dopamine-signaling are responsible of several psychomotor disorders. In order to identify specific functions of these pathways, the Cre/loxP system has been used. Here, we describe the generation and the characterization of a transgenic mouse line expressing the Cre recombinase in...
0 The correct author list is Matthias Stanke , Chi Vinh Duong, Manuela Pape, Markus Geissen, Guido Burbach, Thomas Deller, Hugues Gascan, Christiane Otto, Rosanna Parlato, Gunther Schutz and Hermann ... Rohrer 1 Matthias Stanke , Chi Vinh Duong, Manuela Pape, Markus Geissen, Guido Burbach, Thomas Deller, Hugues Gascan, Rosanna Parlato , Gunther Schutz and Hermann Rohrer Development 133 , 141-150 2 INSERM
The forkhead transcription factor FOXE1 is mutated in patients with Bamforth–Lazarus syndrome that exhibit hair follicle defects, suggesting a possible role for Foxe1 in hair follicle morphogenesis. Here, we report that Foxe1 is specifically expressed in the lower undifferentiated compartment of the hair follicle, at a time and site that parallel activation of the Shh signaling...
