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Engineering vascularized skeletal muscle tissue with transcriptional factor ETV2-induced autologous endothelial cells

Hu for providing adipose-derived mesenchymal stem cells and umbilical cord-derived mesenchymal stem cells. Shuo Lin, Wei Qin and Guanrong Yan designed the research; Guanrong Yan, Ruibin Yan, Yanqiu ... Zhao and Cheng Chen conducted the research; Guanrong Yan, Cheng Chen and Matthew B. Veldman analyzed the data; Shuo Lin, Matthew B. Veldman and Guanrong Yan wrote the Manuscript. Guanrong Yan, Ruibin

Nom1 Mediates Pancreas Development by Regulating Ribosome Biogenesis in Zebrafish

Ribosome biogenesis is an important biological process for proper cellular function and development. Defects leading to improper ribosome biogenesis can cause diseases such as Diamond-Blackfan anemia and Shwachman-Bodian-Diamond syndrome. Nucleolar proteins are a large family of proteins and are involved in many cellular processes, including the regulation of ribosome biogenesis...

A Novel Anti-Tumor Inhibitor Identified by Virtual Screen with PLK1 Structure and Zebrafish Assay

Polo-like kinase 1 (PLK1), one of the key regulators of mitosis, is a target for cancer therapy due to its abnormally high activity in several tumors. Plk1 is highly conserved and shares a nearly identical 3-D structure between zebrafish and humans. The initial 10 mitoses of zebrafish embryonic cleavages occur every∼30 minutes, and therefore provide a rapid assay to evaluate...