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Search: authors:"Ruihao Wang"

5 papers found.
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Severity of traumatic brain injury correlates with long-term cardiovascular autonomic dysfunction

, at rest and upon standing (ANOVA with post hoc testing). Orthostatic challenge; Traumatic brain injury; Autonomic dysfunction; Differences in severity - Max J. Hilz and Ruihao Wang contributed

Valsalva maneuver unveils central baroreflex dysfunction with altered blood pressure control in persons with a history of mild traumatic brain injury

Background Patients with a history of mild TBI (post-mTBI-patients) have an unexplained increase in long-term mortality which might be related to central autonomic dysregulation (CAD). We investigated whether standardized baroreflex-loading, induced by a Valsalva maneuver (VM), unveils CAD in otherwise healthy post-mTBI-patients. Methods In 29 healthy persons (31.3 ± 12.2 years...

Disturbance of the let-7/LIN28 double-negative feedback loop is associated with radio- and chemo-resistance in non-small cell lung cancer

Radio- and chemo-resistance represent major obstacles in the therapy of non-small-cell lung cancer (NSCLC) and the underlying molecular mechanisms are not known. In the present study, during induction of radio- or chemo-resistance in NSCLC cells, dynamic analyses revealed that decreased expression of let-7 induced by irradiation or cisplatin resulted in increased expression of...

Central Autonomic Dysfunction Delays Recovery of Fingolimod Induced Heart Rate Slowing

Background In multiple sclerosis (MS) patients, Fingolimod may induce prolonged heart-rate slowing which might be caused by MS-related central autonomic lesions. Objectives To evaluate whether MS-patients with prolonged heart-rate slowing (> six hours) upon Fingolimod show cardiovascular-autonomic dysfunction before Fingolimod-initiation. Methods Before Fingolimod-initiation, we...

Optimal beam arrangement for pulmonary ventilation image-guided intensity-modulated radiotherapy for lung cancer

Background The principal aim of this study was to evaluate the feasibility of incorporating four-dimensional (4D)-computed tomography (CT)-based functional information into treatment planning and to evaluate the potential benefits of individualized beam setups to better protect lung functionality in patients with non-small cell lung cancer (NSCLC). Methods Peak-exhale and peak...