Currently, some catastrophe models used by the insurance industry account for liquefaction by applying a simple factor to shaking-induced losses. The factor is based only on local liquefaction susceptibility and this highlights the need for a more sophisticated approach to incorporating the effects of liquefaction in loss models. This study compares 11 unique models, each based...
June 13, 2011 : lifelines performance , technical council on lifeline earthquake engineering , Monograph 40 . ASCE, Reston, VA Esposito S , Giovinazzi S , Elefante L , Iervolino I ( 2013 ) Performance of ... for physical elements at seismic risk , vol 27 ., Geotechnical, geological and earthquake engineeringSpringer, Dordrecht, pp 221 - 258 Kongar I , Esposito S , Giovinazzi S ( 2015 ) Post-earthquake
A large number of patients are resistant to taxane-based chemotherapy. Functional mitotic checkpoints are essential for taxane sensitivity. Thus, mitotic regulators are potential markers for therapy response and could be targeted for anticancer therapy. In this study, we identified a novel function of ubiquitin (Ub)-specific processing protease-7 (USP7) that interacts and...
Current theories suggest that mitotic checkpoint proteins are essential for proper cellular response to taxanes, a widely used family of chemotherapeutic compounds. We recently showed that absence or depletion of protein Daxx increases cellular taxol (paclitaxel) resistance—a common trait of patients diagnosed with several malignancies, including breast cancer. Further...