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18 papers found.
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Association between characteristics of pain and stiffness and the functional status of patients with incident polymyalgia rheumatica from primary care

This paper aims to examine the relationship between different characteristics of pain and stiffness and the functional status of patients with newly diagnosed polymyalgia rheumatica (PMR). Baseline analysis of an inception cohort study was conducted. Patients aged ≥18 years, with a new diagnosis of PMR were recruited from 382 English general practices. Participants were mailed a ...

STICKS study – Short-sTretch Inelastic Compression bandage in Knee Swelling following total knee arthroplasty – a feasibility study

Background Postoperative knee swelling is common and impairs early postoperative function following total knee arthroplasty. It was hypothesised that the use of a short-stretch, inelastic compression bandage would reduce knee swelling and improve pain and early function. The aim of this study was to provide preliminary data and test feasibility with a view to informing a larger, ...

The CaMK4/CREB/IRS-2 Cascade Stimulates Proliferation and Inhibits Apoptosis of β-Cells

Progressive reduction in β-cell mass is responsible for the development of type 2 diabetes mellitus, and alteration in insulin receptor substrate 2 (IRS-2) abundance plays a critical role in this process. IRS-2 expression is stimulated by the transcription factor cAMP response element-binding protein (CREB) and we recently demonstrated that Ca2+/calmodulin dependent kinase 4 ...

The Nonconventional MHC Class II Molecule DM Governs Diabetes Susceptibility in NOD Mice

The spontaneous destruction of insulin producing pancreatic beta cells in non-obese diabetic (NOD) mice provides a valuable model of type 1 diabetes. As in humans, disease susceptibility is controlled by the classical MHC class II genes that guide CD4+ T cell responses to self and foreign antigens. It has long been suspected that the dedicated class II chaperone designated HLA-DM ...

Calcium/calmodulin-dependent kinase IV controls glucose-induced Irs2 expression in mouse beta cells via activation of cAMP response element-binding protein

S. J. Persaud B. Liu H. Barbosa Sampaio P. M. Jones D. S. Muller 0 ) Diabetes Research Group, School of Medicine, King's College London , Guy's Campus, London SE1 1UL, UK Aims/hypothesis Irs2 ... caspase-3/7 activities, are consistent with this hypothesis (D. S. Muller, S. J. Persaud, B. Liu and P. M Jones, unpublished data). The precise role of Irs2 in these CaMKIV-mediated effects is now being

Nupr1 deletion protects against glucose intolerance by increasing beta cell mass

Aims/hypothesis The stress-activated nuclear protein transcription regulator 1 (NUPR1) is induced in response to glucose and TNF-α, both of which are elevated in type 2 diabetes, and Nupr1 has been implicated in cell proliferation and apoptosis cascades. We used Nupr1 −/− mice to study the role of Nupr1 in glucose homeostasis under normal conditions and following maintenance on a ...

Isometry of medial collateral ligament reconstruction

, Department of Orthopaedic Surgery, Hospital for Special Surgery , New York, NY 10021, USA 1 M. S. Muller Carroll Clinic , Dallas, TX, USA 2 B. T. Feeley (&) Department of Orthopaedic Surgery, University of

lmmunoelectron microscopical distribution of histones H2B and H3 and protamines during human spermiogenesis

The fine structural distribution of histones H2B and H3, and protamines were localized by means of specific antibodies and ultrastructural immunocytochemistry in nuclei of human spermatids and spermatozoa. The antibodies were used to detect the nuclear basic proteins on sections of testis and ejaculated spermatozoa by immunoelectron microscopy. A quantitative analysis of labelling ...

Prevalence and Severity of Asthma, Rhinitis, and Atopic Eczema in 13- to 14-Year-Old Schoolchildren from Southern Brazil

The objective of this study was to investigate the prevalence and severity of asthma, rhinitis, and atopic eczema in schoolchildren from southern Brazil. A cross-sectional study was carried out with the International Study of Asthma and Allergies in Childhood phase III written questionnaire. The questionnaire was self-applied by 2,948 randomly selected schoolchildren aged 13 to 14 ...

Direct regulation of insulin secretion by angiotensin II in human islets of Langerhans

R. D. Ramracheya . D. S. Muller . Y. Wu . B. J. Whitehouse . G. C. Huang . S. A. Amiel . J. Karalliedde . G. Viberti . P. M. Jones . S. J. Persaud 1 0 ) Beta Cell Development and Function Group

New photocrosslinkable polymers for second-order nonlinear optics

Molecular Engineering J. P. VAIRON S. Muller P. le Barny E. Chastaing P. Robin J. P. Vairon New Photocrosslinkable Polymers for Second-Order Nonlinear Optics Molecular Engineering Laboratoire de

Nucleosomes and histones are present in glomerular deposits in human lupus nephritis.

BACKGROUND: Recently we showed that antinuclear autoantibodies complexed to nucleosomes can bind to heparan sulphate (HS) in the glomerular basement membrane (GBM) via the histone part of the nucleosome. Histones have been identified in glomerular deposits in human and murine lupus nephritis. In addition, a decreased HS staining in the GBM was found, most probably due to masking by ...