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The growing burden of liver cirrhosis: implications for preventive measures

, the challenges could be substantial—highlighting the need for researchers to further address and identify existing knowledge gaps. Conflict of interest Martin C. S. Wong and Junjie Huang declare no

Diseases of complement dysregulation—an overview

Atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathy (C3G), and paroxysmal nocturnal hemoglobinuria (PNH) are prototypical disorders of complement dysregulation. Although complement overactivation is common to all, cell surface alternative pathway dysregulation (aHUS), fluid phase alternative pathway dysregulation (C3G), or terminal pathway dysregulation (PNH...

Efficient pairing-free PRE schemes for multimedia data sharing in IoT

: (1)multi-hop, (2)bidirectional, (3)pairing-free, (4)CCA-secure and (5)publicly verifiable. Acknowledgement I would like to thank Prof. Duncan S. WONG for his instructive suggestions, which have ... Security, and Cloud Computing. Prof. Tang is a member of Chinese Association for Cryptologic Research. Duncan S. Wong received the Ph. D. degree in Computer Science from Northeastern University, Boston, MA

Effect of embedded nanoparticle surface chemistry on plasmonic organic photovoltaic devices

The effect of noble metal nanoparticle (NP) synthesis method on the plasmonic enhancement of organic photovoltaic device performance by these NPs is reviewed. For direct incorporation into a polymer fullerene bulk heterojunction (BHJ) active layer, chemically synthesized colloidal Au or Ag NPs with organic ligands are generally ineffective. Due to the tendency of the ligands in...

Quantitative Viscosity Mapping Using Fluorescence Lifetime Measurements

Lubricant viscosity is a key driver in both the tribological performance and energy efficiency of a lubricated contact. Elastohydrodynamic (EHD) lubrication produces very high pressures and shear rates, conditions hard to replicate using conventional rheometry. In situ rheological measurements within a typical contact are therefore important to investigate how a fluid behaves...

Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype

work was supported by NIH grants R01 CA94233, STTR CA192646 and R01 FD04385 to D.L.D and by R01 HL 111169 to J.S.H. Author Contributions Conceptualization: Shweta Joshi, Alok R. Singh, Simon S. Wong ... , James S. Hagood, Donald L. Durden. Investigation: Shweta Joshi, James S. Hagood, Donald L. Durden. Methodology: Shweta Joshi, Alok R. Singh, Simon S. Wong, Muamera Zulcic, Min Jiang. Resources: Annie

Antimicrobial resistance in coagulase-positive staphylococci isolated from companion animals in Australia: A one year study

Methicillin-resistant coagulase-positive staphylococci (CoPS) have become increasingly recognised as opportunistic pathogens that limit therapeutic options in companion animals. The frequency of methicillin resistance amongst clinical isolates on an Australia-wide level is unknown. This study determined antimicrobial susceptibility patterns for CoPS isolated from clinical...

Opportunities in the design and application of RNA for gene expression control

The past decade of synthetic biology research has witnessed numerous advances in the development of tools and frameworks for the design and characterization of biological systems. Researchers have focused on the use of RNA for gene expression control due to its versatility in sensing molecular ligands and the relative ease by which RNA can be modeled and designed compared to...

The evolution of early childhood education policy in Hong Kong

Almost all 3- to 6-year-olds attend preschool programmes in Hong Kong; however, early childhood education (ECE) had been relatively neglected by the Hong Kong government until 2000 when the reform of school education system was initiated. Since then, notions of ‘child-centredness’ and holistic development have been promulgated as the core values of ECE. Against this backdrop...

Mentored peer review of standardized manuscripts as a teaching tool for residents: a pilot randomized controlled multi-center study

Background There is increasing need for peer reviewers as the scientific literature grows. Formal education in biostatistics and research methodology during residency training is lacking. In this pilot study, we addressed these issues by evaluating a novel method of teaching residents about biostatistics and research methodology using peer review of standardized manuscripts. We...

Socioeconomic Determinants of Multimorbidity: A Population-Based Household Survey of Hong Kong Chinese

Introduction Multimorbidity has been well researched in terms of consequences and healthcare implications. Nevertheless, its risk factors and determinants, especially in the Asian context, remain understudied. We tested the hypothesis of a negative relationship between socioeconomic status and multimorbidity, with contextually different patterns from those observed in the West...

Zeaxanthin-independent energy quenching and alternative electron sinks cause a decoupling of the relationship between the photochemical reflectance index (PRI) and photosynthesis in an evergreen conifer during spring

In evergreen conifers, the winter down-regulation of photosynthesis and its recovery during spring are the result of a reorganization of the chloroplast and adjustments of energy-quenching mechanisms. These phenological changes may remain undetected by remote sensing, as conifers retain green foliage during periods of photosynthetic down-regulation. The aim was to assess if the...

Transapical transcatheter aortic valve replacement in patients with or without prior coronary artery bypass graft operation

Background Transapical approach (TA) is an established access alternative to the transfemoral technique in patients undergoing transcatheter aortic valve replacement (TAVR) for treatment of symptomatic aortic valve stenosis. The impact of prior coronary artery bypass grafting (CABG) on clinical outcomes in patients undergoing TA-TAVR is not well defined. Methods A single center...

Reliability and Validity Study of Clinical Ultrasound Imaging on Lateral Curvature of Adolescent Idiopathic Scoliosis

Background Non-ionizing radiation imaging assessment has been advocated for the patients with adolescent idiopathic scoliosis (AIS). As one of the radiation-free methods, ultrasound imaging has gained growing attention in scoliosis assessment over the past decade. The center of laminae (COL) method has been proposed to measure the spinal curvature in the coronal plane of...

Anonymous Three-Party Password-Authenticated Key Exchange Scheme for Telecare Medical Information Systems

Telecare Medical Information Systems (TMIS) provide an effective way to enhance the medical process between doctors, nurses and patients. For enhancing the security and privacy of TMIS, it is important while challenging to enhance the TMIS so that a patient and a doctor can perform mutual authentication and session key establishment using a third-party medical server while the...

Is Alcohol Use Disorder Identification Test (AUDIT) or Its Shorter Versions More Useful to Identify Risky Drinkers in a Chinese Population? A Diagnostic Study

Objective To examine the diagnostic performance of shorter versions of Alcohol Use Disorder Identification Test (AUDIT), including Alcohol Consumption (AUDIT-C), in identifying risky drinkers in primary care settings using conventional performance measures, supplemented by decision curve analysis and reclassification table. Study design and Setting A cross-sectional study of...