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17 papers found.
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Is Time to Reach EDSS 6.0 Faster in Patients with Late-Onset versus Young-Onset Multiple Sclerosis?

Background & Objectives Published natural history data on late-onset of multiple sclerosis are limited. We aimed to assess the risk of attaining EDSS 6.0 among patients with late-onset (> 40 years) MS (LOMS) and young-onset (18–40 years) MS (YOMS). Methods This cross-sectional cohort study was conducted to identify LOMS and YOMS patients’ with relapsing remitting course at MS...

Magnetic Properties of Polyvinyl Alcohol and Doxorubicine Loaded Iron Oxide Nanoparticles for Anticancer Drug Delivery Applications

The current study emphasizes the synthesis of iron oxide nanoparticles (IONPs) and impact of hydrophilic polymer polyvinyl alcohol (PVA) coating concentration as well as anticancer drug doxorubicin (DOX) loading on saturation magnetization for target drug delivery applications. Iron oxide nanoparticles particles were synthesized by a reformed version of the co-precipitation...

Non-parametric analysis of seasonality in birth and multiple sclerosis risk in second generation of migrants in Kuwait

Saeed Akhtar 0 Raed Alroughani Ahmad Al-Shammari Jarrah Al-Abkal Yasser Ayad 0 Department of Community Medicine & Behavioural Sciences, Faculty of Medicine, University of Kuwait , PO Box 24923

Comparison of upstream regulators in human ex vivo cultured cornea limbal epithelial stem cells and differentiated corneal epithelial cells

Ole Kristoffer Olstad Saeed Akhtar Morten C Moe Goran Petrovski 0 1 0 Stem Cells and Eye Research Laboratory, University of Debrecen , Debrecen , Hungary 1 Apoptosis and Genomics Research Group of

Wheat germ oil enrichment in broiler feed with α-lipoic acid to enhance the antioxidant potential and lipid stability of meat

Background Lipid peroxidation is the cause of declining the meat quality. Natural antioxidants plays a vital role in enhancing the stability and quality of meat. The supplementation of natural antioxidants in feed decreases lipid peroxidation and improves the stability of meat. Methods The present research was conducted to determine the effect of α-lipoic acid, α-tocopherol and...

Multilevel Modeling of Household Contextual Determinants of Tuberculin Skin Test Positivity among Contacts of Infectious Tuberculosis Patients, Umerkot, Pakistan

, Kuwait; Department of Community Health Sciences, Aga Khan University , Stadium Road, Karachi 74800 , Pakistan 2 Authors' addresses: Saeed Akhtar, Faculty of Medicine, Kuwait University , PO Box 24923

MULTILEVEL MODELING OF INTRA-HOUSEHOLD SPREAD OF HEPATITIS C VIRUS INFECTION, KARACHI, PAKISTAN

Khan University , Stadium Road, Karachi , Pakistan; Department of Pathology and Microbiology, Aga Khan University , Stadium Road, Karachi , Pakistan 1 Authors' addresses: Saeed Akhtar, Department of

Nonlinear pattern of pulmonary tuberculosis among migrants at entry in Kuwait: 1997–2006

Background There is a paucity of published data on the pattern of pulmonary tuberculosis among migrant workers entering Middle Eastern countries particularly Kuwait. The objectives of this study were to use routine health surveillance data i) to estimate the prevalence of pulmonary tuberculosis among migrant workers at entry in Kuwait and ii) to determine the occurrence of any...

Spectral analysis of HIV seropositivity among migrant workers entering Kuwait

Background There is paucity of published data on human immunodeficiency virus (HIV) seroprevalence among migrant workers entering Middle-East particularly Kuwait. We took advantage of the routine screening of migrants for HIV infection, upon arrival in Kuwait from the areas with high HIV prevalence, to 1) estimate the HIV seroprevalence among migrant workers entering Kuwait and...

Seasonality in pulmonary tuberculosis among migrant workers entering Kuwait

Background There is paucity of data on seasonal variation in pulmonary tuberculosis (TB) in developing countries contrary to recognized seasonality in the TB notification in western societies. This study examined the seasonal pattern in TB diagnosis among migrant workers from developing countries entering Kuwait. Methods Monthly aggregates of TB diagnosis results for consecutive...

Correlates of cigarette smoking among male college students in Karachi, Pakistan

Background About 1.3 billion people are regular smokers world wide and every day between 8,200 and 9,900 young people start to smoke, risking rapid addiction to nicotine. Transition from high school to college is a critical period to adopt healthy habits and life style. Therefore, it is important to understand the factors that might influence their smoking habit. Our study aims...

Prevalence and determinants of asthma in adult male leather tannery workers in Karachi, Pakistan: A cross sectional study

Background This study aimed to estimate the prevalence and to identify some risk factors of adult asthma in male leather tannery workers in Karachi, Pakistan. Methods A cross sectional study was conducted from August 2003 to March 2004 on leather tannery workers of Karachi, Pakistan. Data were collected from 641 workers engaged in 95 different tanneries in Korangi industrial area...

Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells

Marchesi Juha M. T. Hyttinen Niko Kivinen Reijo Sironen Kirsi Rilla Saeed Akhtar Alessandro Provenzani Vito Giuseppe D'Agostino Stefano Govoni Alessia Pascale Hansjurgen Agostini Goran Petrovski Antero

Prevalence and Factors Associated with Intestinal Parasitic Infection among Children in an Urban Slum of Karachi

Background Intestinal parasitic infections are endemic worldwide and have been described as constituting the greatest single worldwide cause of illness and disease. Poverty, illiteracy, poor hygiene, lack of access to potable water and hot and humid tropical climate are the factors associated with intestinal parasitic infections. The study aimed to estimate prevalence and...

Epidemiologic study of chronic hepatitis B virus infection in male volunteer blood donors in Karachi, Pakistan

Background The magnitude of chronic infection with hepatitis B virus (HBV) varies substantially between the countries. A better understanding of incidence and/ or prevalence of HBV infection and associated risk factors provides insight into the transmission of this infection in the community. The purpose of this investigation was to estimate the prevalence of and to identify the...

Hyperendemic pulmonary tuberculosis in peri-urban areas of Karachi, Pakistan

Background Currently there are very limited empirical data available on the prevalence of pulmonary tuberculosis among residents of marginalized settings in Pakistan. This study assessed the prevalence of pulmonary tuberculosis through active case detection and evaluated predictors of pulmonary tuberculosis among residents of two peri-urban neighbourhoods of Karachi, Pakistan...

Hepatitis B and C: prevalence and risk factors associated with seropositivity among children in Karachi, Pakistan

Background Infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) can lead to chronic liver disease and hepato-cellular carcinoma (HCC). This cross-sectional study estimated the prevalence and identified risk factors associated with Hepatitis B surface antigen (HBsAg) and HCV antibody (anti-HCV) sero-positivity among children 1 to 15 years of age. Methods The study...