Detailed knowledge of the three-dimensional (3D) structure of a protein is essential for the proper understanding of its function(s) that could be modified through posttranslational modifications (PTMs). Among these PTMs, alterations of serine/threonine residues of a protein through phosphorylation and O-glycosylation are extremely dynamic and could modulate the functions of a...
Detailed knowledge of the three-dimensional (3D) structure of a protein is essential for the proper understanding of its function(s) that could be modified through posttranslational modifications (PTMs). Among these PTMs, alterations of serine/threonine residues of a protein through phosphorylation and O-glycosylation are extremely dynamic and could modulate the functions of a...
Detailed knowledge of the three-dimensional (3D) structure of a protein is essential for the proper understanding of its function(s) that could be modified through posttranslational modifications (PTMs). Among these PTMs, alterations of serine/threonine residues of a protein through phosphorylation and O-glycosylation are extremely dynamic and could modulate the functions of a...
Background Hepatitis C virus (HCV) causes liver fibrosis that may lead to liver cirrhosis or hepatocellular carcinoma (HCC), and may partially depend on infecting viral genotype. HCV genotype 3a is being more common in Asian population, especially Pakistan; the detail mechanism of infection still needs to be explored. In this study, we investigated and compared the gene...
Hepatitis C virus (HCV) causes liver fibrosis that may lead to liver cirrhosis or hepatocellular carcinoma (HCC), and may partially depend on infecting viral genotype. HCV genotype 3a is being more common in Asian population, especially Pakistan; the detail mechanism of infection still needs to be explored. In this study, we investigated and compared the gene expression profile...
Research Officer, while Sajida Hassan (PhD Molecular Biology) is Principal Investigator at CEMB, University of the Punjab, Lahore. 1. Giannini C , Brechot C : Hepatitis C virus biology. Cell Death Differ
scholars, Bushra Ijaz (M Phil Molecular Biology) and Waqar Ahmad (M Phil Chemistry) are Research Officer, while Sajida Hassan (PhD Molecular Biology) is Principal Investigator at CEMB, University of the
Ashfaq (PhD Molecular Biology), and Sajida Hassan (PhD Molecular Biology) at CEMB, University of the Punjab, Lahore. Competing interests The authors declare that they have no competing interests. 1
), Asim Pervaiz (M.Phil Molecular Biology), Usman Ali Ashfaq (PhD Molecular Biology), and Sajida Hassan (PhD Molecular Biology) at CEMB, University of the Punjab, Lahore. List of abbreviations 5'UTR
Gull S (MSc Biochemistry) are Research Officer; Javed FT is Head Pathology Department Jinnah Hospital, Lahore; while Sajida Hassan (PhD Molecular Biology) is Principal Investigator at CEMB, University of
Biochemistry) are Research Officer; Javed FT is Head Pathology Department Jinnah Hospital, Lahore; while Sajida Hassan (PhD Molecular Biology) is Principal Investigator at CEMB, University of the Punjab, Lahore
Chronic hepatitis C virus (HCV) induced hepatocellular carcinoma (HCC) is a primary indication for liver transplantation (LT). In western countries, the estimated rate of HCC recurrence following LT is between 15% and 20% and is a major cause of mortality. Currently, there is no standard method to treat patients who are at high risk for HCC recurrence. The aim of this study was...
Chronic hepatitis C virus (HCV) induced hepatocellular carcinoma (HCC) is a primary indication for liver transplantation (LT). In western countries, the estimated rate of HCC recurrence following LT is between 15% and 20% and is a major cause of mortality. Currently, there is no standard method to treat patients who are at high risk for HCC recurrence. The aim of this study was...
Chronic hepatitis C virus (HCV) induced hepatocellular carcinoma (HCC) is a primary indication for liver transplantation (LT). In western countries, the estimated rate of HCC recurrence following LT is between 15% and 20% and is a major cause of mortality. Currently, there is no standard method to treat patients who are at high risk for HCC recurrence. The aim of this study was...
Chronic hepatitis C virus (HCV) induced hepatocellular carcinoma (HCC) is a primary indication for liver transplantation (LT). In western countries, the estimated rate of HCC recurrence following LT is between 15% and 20% and is a major cause of mortality. Currently, there is no standard method to treat patients who are at high risk for HCC recurrence. The aim of this study was...
CEMB. Sajida Hassan (PhD Molecular Biology) is principle investigator at CEMB, University of the Punjab, Lahore.
Siddiqui (M.Phil Molecular Biology) and Bushra Ijaz and Waqar Ahmad are research officer at CEMB. Sajida Hassan (PhD Molecular Biology) is principle investigator at CEMB, University of the Punjab, Lahore
Siddique 0 Waqar Ahmad 0 Sajida Hassan 0 0 Applied and Functional Genomics Lab, Centre of Excellence in Molecular Biology, University of the Punjab , Pakistan Background: Hepatitis C virus (HCV) is a major
), Sajida Hassan (PhD Molecular Biology) and Sheikh Riazuddin (PhD molecular Biology and Dean Post graduate study at Allama Iqbal medical college, Lahore Competing interests The authors declare that they have
Background Hepatitis C virus (HCV) is one of the major health concerns globally, with genotype 3a as the most prevalent in Pakistan. Lack of efficient HCV genotype 3a small animal models as well as genomic replicons has hampered the complete understanding of its life cycle, pathogenesis and therapeutic options. In this study we aimed to develop a persistent HCV genotype 3a...
