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Search: authors:"Sang-Won Park"

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Potential for therapeutic manipulation of the UPR in disease

Sang Won Park Umut Ozcan Abbreviations ER UPR ERAD PERK 0 ) Division of Endocrinology, Boston Children's Hospital, Harvard Medical School , Boston, MA, USA Increased endoplasmic reticulum (ER

Methamphetamine-induced changes in the striatal dopamine pathway in μ-opioid receptor knockout mice

Background Repeated exposure to methamphetamine (METH) can cause not only neurotoxicity but also addiction. Behavioral sensitization is widely used as an animal model for the study of drug addiction. We previously reported that the μ-opioid receptor knockout mice were resistant to METH-induced behavioral sensitization but the mechanism is unknown. Methods The present study...

DNA Repair in Human Pluripotent Stem Cells Is Distinct from That in Non-Pluripotent Human Cells

The potential for human disease treatment using human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells (iPSCs), also carries the risk of added genomic instability. Genomic instability is most often linked to DNA repair deficiencies, which indicates that screening/characterization of possible repair deficiencies in pluripotent human stem...