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Living with Juvenile Idiopathic Arthritis: Parent and Physician Perspectives

playground. We were determined to find answers, and our pursuit for resolution and our journey toward relief had our path cross with Dr. Sangeeta Sule at Johns Hopkins Children’s Center. My son’s initial ... . Disclosures. Shelly Heath-Watson and Sangeeta Sule have nothing to disclose. Compliance with Ethics Guidelines. This article does not contain any new studies with human or animal subjects performed by any of

Abnormal body composition, cardiovascular endurance, and muscle strength in pediatric SLE

Background Children with SLE are known to have higher fat mass compared to their peers but there are no published data regarding exercise capacity as measured by cardiovascular endurance and muscle strength. In our pilot study of ten children with SLE, we sought to examine body composition, cardiovascular endurance, and isometric muscle strength. Findings Ten pediatric SLE...

Abnormal Production of Pro- and Anti-Inflammatory Cytokines by Lupus Monocytes in Response to Apoptotic Cells

Monocytes are a key component of the innate immune system involved in the regulation of the adaptive immune response. Previous studies have focused on apoptotic cell clearance abnormalities in systemic lupus erythematosus (SLE) monocytes. However, whether SLE monocytes might express unique patterns of cytokine secretion in response to apoptotic cells is still unknown. Here, we...