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19 papers found.
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Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries

& Miren Dorronsoro 7,11,12 & Courtney Dow 13 & Guy Fagherazzi 13 & Sara Grioni 14 & Marc J. Gunter 15 & José María Huerta 7,16 & Daniel B. Ibsen 17 & Marianne Uhre Jakobsen 17,18 & Rudolf Kaaks 19 & Timothy

Micronutrients Involved in One-Carbon Metabolism and Risk of Breast Cancer Subtypes

Background Vitamins involved in one-carbon metabolism are hypothesized to influence breast cancer (BC) risk. However, epidemiologic studies that examined associations between B vitamin intake and BC risk have provided inconsistent results. We prospectively examined, in the Italian ORDET cohort, whether B vitamin consumption was associated with risk of BC and BC subtypes. Methods...

Dietary Total Antioxidant Capacity and Colorectal Cancer in the Italian EPIC Cohort

Background Colorectal cancer is the third most common cancer worldwide. Diet has been hypothesized as involved in colorectal cancer etiology, but few studies on the influence of total dietary antioxidant intake on colorectal cancer risk have been performed. Methods We investigated the association between colorectal cancer risk and the total antioxidant capacity (TAC) of the diet...

Metabolic Syndrome and Breast Cancer Risk: A Case-Cohort Study Nested in a Multicentre Italian Cohort

Background Metabolic syndrome (defined as at least three among abdominal obesity, high blood triglycerides, low high-density lipoprotein cholesterol, high blood glucose, and high blood pressure) is emerging as a risk factor for breast cancer; however few studies – most confined to postmenopausal women – have investigated associations between breast cancer risk and metabolic...

Espresso Coffee Consumption and Risk of Coronary Heart Disease in a Large Italian Cohort

Background The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the association between Italian-style (espresso and mocha) coffee consumption and CHD risk. Methods We investigated 12,800 men and 30,449 women without history of cardiovascular disease recruited to the EPICOR...

Endogenous sex steroids in premenopausal women and risk of breast cancer: the ORDET cohort

Eva S Schernhammer 0 1 2 4 Francesca Sperati 8 Pedram Razavi 7 Claudia Agnoli 6 Sabina Sieri 6 Franco Berrino 5 Vittorio Krogh 6 Carlo Alberto Abbagnato 10 Sara Grioni 6 Giovanni Blandino 8 9 Holger

Dietary Glycemic Load and Glycemic Index and Risk of Cerebrovascular Disease in the EPICOR Cohort

Background Studies on the association of stroke risk to dietary glycemic index (GI) and glycemic load (GL) have produced contrasting results. Objective To investigate the relation of dietary GI and GL to stroke risk in the large EPIC-Italy cohort (EPICOR) recruited from widely dispersed geographic areas of Italy. Design We studied 44099 participants (13,646 men and 30,453 women...

A prospective study of dietary selenium intake and risk of type 2 diabetes

Background Growing evidence raises concern about possible associations of high selenium exposure with diabetes in selenium-replete populations such as the US. In countries with lower selenium status, such as Italy, there is little epidemiological evidence on the association between selenium and diabetes. This study examined the prospective association between dietary selenium...

Lifestyle factors and mortality risk in individuals with diabetes mellitus: are the associations different from those in individuals without diabetes?

Aims/hypothesis Thus far, it is unclear whether lifestyle recommendations for people with diabetes should be different from those for the general public. We investigated whether the associations between lifestyle factors and mortality risk differ between individuals with and without diabetes. Methods Within the European Prospective Investigation into Cancer and Nutrition (EPIC...

Urinary estrogen metabolites and prostate cancer: a case-control study and meta-analysis

Francesca Sperati 3 Sara Grioni 6 Saverio Stranges 5 Kim C Westerlind 4 Giovanni Blandino 9 Michele Gallucci 8 Rossella Lauria 2 Luca Malorni 2 10 Paola Muti 11 0 Department of Medicine, State

HbA1c Measured in Stored Erythrocytes Is Positively Linearly Associated with Mortality in Individuals with Diabetes Mellitus

Annelli Sandbaek Kim Overvad Larraitz Arriola Eva Ardanaz Calogero Saieva Sara Grioni Rosario Tumino Carlotta Sacerdote Amalia Mattiello Annemieke M. W. Spijkerman Daphne L. van der A Joline W. J. Beulens

Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity

We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterize their association with intermediate phenotypes, and to investigate their role in type 2 diabetes (T2D) risk among normal-weight, overweight, and obese individuals. We investigated the association of genetic scores with euglycemic-hyperinsulinemic clamp– and oral glucose...

The Association Between Dietary Flavonoid and Lignan Intakes and Incident Type 2 Diabetes in European Populations: The EPIC-InterAct study

OBJECTIVE To study the association between dietary flavonoid and lignan intakes, and the risk of development of type 2 diabetes among European populations.

Age at Menarche and Type 2 Diabetes Risk: The EPIC-InterAct study

OBJECTIVE Younger age at menarche, a marker of pubertal timing in girls, is associated with higher risk of later type 2 diabetes. We aimed to confirm this association and to examine whether it is explained by adiposity.

Hemochromatosis (HFE) gene mutations and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Hereditary hemochromatosis (HH) is a strong risk factor for hepatocellular cancer, and mutations in the HFE gene associated with HH and iron overload may be related to other tumors, but no studies have been reported for gastric cancer (GC). A nested case–control study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC), including 365...

Associations Between General and Abdominal Adiposity and Mortality in Individuals With Diabetes Mellitus

Studio e la Prevenzione Oncologica, Florence, Italy (Benedetta Bendinelli); Nutritional Epidemiology Unit, IRCCS Istituto Nazionale Tumori, Milan, Italy (Sara Grioni); Cancer Registry and Histopathology

Lactase Persistence and Bitter Taste Response: Instrumental Variables and Mendelian Randomization in Epidemiologic Studies of Dietary Factors and Cancer Risk

Consumption of dairy products seems to increase the risk of cancer at several sites, while intake of cruciferous vegetables could have protective effects. However, these dietary intakes are subject to measurement error, and associations with cancer could be due to confounders. Mendelian randomization has been suggested as a way to overcome confounding by exploiting the random...

Dietary Fat Intake and Development of Specific Breast Cancer Subtypes

Vasilopoulou, María-José Sánchez, Maria-Dolores Chirlaque, Pilar Amiano, J. Ramón Quirós, Eva Ardanaz, Genevieve Buckland, Giovanna Masala, Salvatore Panico, Sara Grioni, Carlotta Sacerdote, Rosario Tumino

Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk: Results from the EPIC-InterAct study

OBJECTIVE Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk.