Advanced search    

Search: authors:"Sarah E. Medland"

24 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries

NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation. Compliance with Ethical Standards Conflict of interest Dominique F. Maciejewski, Miguel E. Renteria, Abdel Abdellaoui, Sarah E ... . Medland, Lauren R. Few, Scott D. Gordon, Pamela A.F. Madden, Grant Montgomery, Timothy J. Trull, Andrew C. Heath, Dixie J. Statham, Nicholas G. Martin, Brendan P. Zietsch, and Karin J.H. Verweij declare

Identification of shared risk loci and pathways for bipolar disorder and schizophrenia

Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical and genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological overlap remain largely unknown. A recent SCZ genome wide association study (GWAS) by the ...

Head Motion and Inattention/Hyperactivity Share Common Genetic Influences: Implications for fMRI Studies of ADHD

Head motion (HM) is a well known confound in analyses of functional MRI (fMRI) data. Neuroimaging researchers therefore typically treat HM as a nuisance covariate in their analyses. Even so, it is possible that HM shares a common genetic influence with the trait of interest. Here we investigate the extent to which this relationship is due to shared genetic factors, using HM ...

Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease

Derrek P Hibar Thomas E Nichols Sarah E Medland Paul M Thompson Reinmar Hager 0 0 Computational and Evolutionary Biology, Faculty of Life Sciences, University of Manchester , Michael Smith Building, Oxford

Genetic Basis of a Cognitive Complexity Metric

Relational complexity (RC) is a metric reflecting capacity limitation in relational processing. It plays a crucial role in higher cognitive processes and is an endophenotype for several disorders. However, the genetic underpinnings of complex relational processing have not been investigated. Using the classical twin model, we estimated the heritability of RC and genetic overlap ...

Unraveling the Genetic Etiology of Adult Antisocial Behavior: A Genome-Wide Association Study

Crime poses a major burden for society. The heterogeneous nature of criminal behavior makes it difficult to unravel its causes. Relatively little research has been conducted on the genetic influences of criminal behavior. The few twin and adoption studies that have been undertaken suggest that about half of the variance in antisocial behavior can be explained by genetic factors. In ...

Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

& Ignacio Martínez-Zalacaín 106 & - Jean-Luc Martinot 107,108 & David Mataix-Cols 109 & Karen Mather 19 & Colm McDonald 48 & Katie L. McMahon 110 & Sarah E. Medland 105 & José M. Menchón 106,111,112 & Derek

Attention Deficit Hyperactivity Disorder in Australian Adults: Prevalence, Persistence, Conduct Problems and Disadvantage

Background The Prevalence and persistence of ADHD have not been described in young Australian adults and few studies have examined how conduct problems (CP) are associated with ADHD for this age group. We estimate lifetime and adult prevalence and persistence rates for three categories of ADHD for 3795 Australian adults, and indicate how career, health and childhood risk factors ...

A Genome-Wide Study on the Perception of the Odorants Androstenone and Galaxolide

Twin pairs and their siblings rated the intensity of the odorants amyl acetate, androstenone, eugenol, Galaxolide, mercaptans, and rose (N = 1573). Heritability was established for ratings of androstenone (h 2 = 0.30) and Galaxolide (h2 = 0.34) but not for the other odorants. Genome-wide association analysis using 2.3 million single nucleotide polymorphisms indicated that the most ...

Mining the Human Phenome Using Allelic Scores That Index Biological Intermediates

It is common practice in genome-wide association studies (GWAS) to focus on the relationship between disease risk and genetic variants one marker at a time. When relevant genes are identified it is often possible to implicate biological intermediates and pathways likely to be involved in disease aetiology. However, single genetic variants typically explain small amounts of disease ...

First all-in-one diagnostic tool for DNA intelligence: genome-wide inference of biogeographic ancestry, appearance, relatedness, and sex with the Identitas v1 Forensic Chip

When a forensic DNA sample cannot be associated directly with a previously genotyped reference sample by standard short tandem repeat profiling, the investigation required for identifying perpetrators, victims, or missing persons can be both costly and time consuming. Here, we describe the outcome of a collaborative study using the Identitas Version 1 (v1) Forensic Chip, the first ...

Linkage Analysis of a Model Quantitative Trait in Humans: Finger Ridge Count Shows Significant Multivariate Linkage to 5q14.1

The finger ridge count (a measure of pattern size) is one of the most heritable complex traits studied in humans and has been considered a model human polygenic trait in quantitative genetic analysis. Here, we report the results of the first genome-wide linkage scan for finger ridge count in a sample of 2,114 offspring from 922 nuclear families. Both univariate linkage to the ...

Educational Attainment: A Genome Wide Association Study in 9538 Australians

Background Correlations between Educational Attainment (EA) and measures of cognitive performance are as high as 0.8. This makes EA an attractive alternative phenotype for studies wishing to map genes affecting cognition due to the ease of collecting EA data compared to other cognitive phenotypes such as IQ. Methodology In an Australian family sample of 9538 individuals we ...

Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium

7 9 11 12 15 17 18 19 20 21 22 23 25 26 27 28 29 31 32 35 36 37 40 41 42 43 44 45 Sarah E. Medland 0 1 2 3 4 6 7 9 11 12 15 17 18 19 20 21 22 23 25 26 27 28 29 31 32 35 36 37 40 41 42 43 44 45 Evelin

The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12

The perceived taste intensities of quinine HCl, caffeine, sucrose octaacetate (SOA) and propylthiouracil (PROP) solutions were examined in 1457 twins and their siblings. Previous heritability modeling of these bitter stimuli indicated a common genetic factor for quinine, caffeine and SOA (22–28%), as well as separate specific genetic factors for PROP (72%) and quinine (15%). To ...

Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations

Serum gamma-glutamyl transferase (GGT) activity is a marker of liver disease which is also prospectively associated with the risk of all-cause mortality, cardiovascular disease, type 2 diabetes and cancers. We have discovered novel loci affecting GGT in a genome-wide association study (rs1497406 in an intergenic region of chromosome 1, P = 3.9 × 10−8; rs944002 in C14orf73 on ...

A Genome-Wide Association Study Identifies Five Loci Influencing Facial Morphology in Europeans

Katrin Hegenscheid Liisa Bevan Zdenka Pausova Sarah E. Medland Grant W. Montgomery Margaret J. Wright Carol Wicking Stefan Boehringer Timothy D. Spector Toma s Paus Nicholas G. Martin Reiner Biffar Manfred

Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

Androgenetic alopecia (AGA) is a highly heritable condition and the most common form of hair loss in humans. Susceptibility loci have been described on the X chromosome and chromosome 20, but these loci explain a minority of its heritable variance. We conducted a large-scale meta-analysis of seven genome-wide association studies for early-onset AGA in 12,806 individuals of European ...

Assumption-Free Estimation of Heritability from Genome-Wide Identity-by-Descent Sharing between Full Siblings

The study of continuously varying, quantitative traits is important in evolutionary biology, agriculture, and medicine. Variation in such traits is attributable to many, possibly interacting, genes whose expression may be sensitive to the environment, which makes their dissection into underlying causative factors difficult. An important population parameter for quantitative traits ...

Genome-wide association identifies ATOH7 as a major gene determining human optic disc size

Stuart Macgregor Alex W. Hewitt Pirro G. Hysi Jonathan B. Ruddle Sarah E. Medland Anjali K. Henders Scott D. Gordon Toby Andrew Brian McEvoy Paul G. Sanfilippo Francis Carbonaro Vikas Tah Yi Ju Li