Background. Human leukocyte antigen (HLA) supertypes are groups of functionally related alleles that present structurally similar antigens to the immune system. Objectives. To analyze HLA class I supertype associations with clinical outcome in hospitalized Thai children with acute dengue illness. Methods. Seven hundred sixty-two patients and population-matched controls recruited...
Severe dengue virus (DENV) infection is characterized by a cascade of cytokine production, including the production of tumor necrosis factor–α (TNF-α) and lymphotoxin-α (LT-α). We have analyzed a variety of polymorphisms in the TNF and LTA genes of 435 ethnic Thais who had subclinical DENV infection, primary or secondary dengue fever (DF), or primary or secondary dengue...
