techniques. As datasets become larger and more diverse, machine learning techniques can be implemented. Author Contributions Conceptualization: Mark T. Scimone, Savitri Krishnamurthy, Dorin Preda, Jesung ... Park, John Grimble, Nicusor Iftimia. Data curation: Mark T. Scimone, Savitri Krishnamurthy, Dorin Preda, John Grimble, Min Song, Kechen Ban. Formal analysis: Gopi Maguluri. Funding acquisition
Inflammatory breast cancer (IBC) has a highly invasive and metastatic phenotype. However, little is known about its genetic drivers. To address this, we report the largest cohort of whole-genome sequencing (WGS) of IBC cases. We performed WGS of 20 IBC samples and paired normal blood DNA to identify genomic alterations. For comparison, we used 23 matched non-IBC samples from the...
. Sharjeel Sabir accepts responsibility for the integrity and validity of the data collected and analyzed. Author Contributions Conceptualization: Sharjeel H. Sabir, Savitri Krishnamurthy, Sanjay Gupta ... , Gordon B. Mills, Wei Wei, Andrea C. Cortes, Kenna R. Mills Shaw, Rajyalakshmi Luthra, Michael J. Wallace. Data curation: Sharjeel H. Sabir, Savitri Krishnamurthy, Wei Wei, Andrea C. Cortes, Rajyalakshmi
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Tissue sampling is a problematic issue for inflammatory breast carcinoma, and immediate evaluation following core needle biopsy is needed to evaluate specimen adequacy. We sought to determine if confocal fluorescence microscopy provides sufficient resolution to evaluate specimen adequacy by comparing invasive tumor cellularity estimated from standard histologic images to invasive...
Introduction Pathologists currently diagnose breast lesions through histologic assessment, which requires fixation and tissue preparation. The diagnostic criteria used to classify breast lesions are qualitative and subjective, and inter-observer discordance has been shown to be a significant challenge in the diagnosis of selected breast lesions, particularly for borderline...
AuthorsSearch for Jessica L. Dobbs in:PubMed • Google Scholar Search for Jenna L. Mueller in:PubMed • Google Scholar Search for Savitri Krishnamurthy in:PubMed • Google Scholar Search for Dongsuk Shin
Circulating tumor cells (CTCs) can be identified in approximately 25 % of stage I-III breast cancer patients; CTCs presence is a predictor of poor outcome in metastatic breast cancer, but little is known regarding the prognostic significance of CTCs in non-metastatic triple-negative breast cancer (TNBC) patients. The aim of this study was to determine whether CTCs predict worse...
Valero, Melissa L. Bondy, Massimo Cristofinalli, Wendy A. Woodward, Randa ElZein. Data curation: Tamer M. Fouad, Naoto T. Ueno, Ricardo H. Alvarez, Savitri Krishnamurthy, Anthony Lucci, James M. Reuben ... acquisition: Naoto T. Ueno, Massimo Cristofinalli, Wendy A. Woodward. Investigation: Naoto T. Ueno, Ricardo H. Alvarez, Savitri Krishnamurthy, Vicente Valero, Melissa L. Bondy, Massimo Cristofinalli, Wendy A
, Wendy A. Woodward, James M. Reuben, Savitri Krishnamurthy, Naoto T. Ueno. Data curation: Kenichi Harano, Robert S. Seitz, Stephan W. Morris, Daniel B. Bailey, David R. Hout, Rachel L. Skelton. Formal ... . Skelton, Brian Z. Ring, Hiroko Masuda, Arvind U. K. Rao, Steven Van Laere, Francois Bertucci, Wendy A. Woodward, James M. Reuben, Savitri Krishnamurthy, Naoto T. Ueno. 7 / 8 1. Dent R , Trudeau M
Minimally invasive procedures, such as fine needle aspiration and core needle biopsy, are commonly used for the diagnosis in solid organ malignancies. In the era of targeted therapy, it is crucial for molecular testing to be performed on these limited volume specimens. Although several recent studies have demonstrated the utility of small biopsy specimens for molecular testing...
Introduction Inflammatory breast cancer (IBC) is an aggressive type of breast cancer, characterized by very rapid progression, enlargement of the breast, skin edema causing an orange peel appearance (peau d’orange), erythema, thickening, and dermal lymphatic invasion. It is characterized by E-cadherin overexpression in the primary and metastatic disease, but to date no robust...
Inflammatory breast cancer (IBC) is an aggressive type of breast cancer, characterized by very rapid progression, enlargement of the breast, skin edema causing an orange peel appearance (peau d’orange), erythema, thickening, and dermal lymphatic invasion. It is characterized by E-cadherin overexpression in the primary and metastatic disease, but to date no robust molecular...
Introduction Epithelial to mesenchymal transition (EMT) is associated with the basal-like breast cancer phenotypes. Sixty percent of basal-like cancers have been shown to express wild-type estrogen receptor beta (ERβ1). However, it is still unclear whether the ERβ expression is related to EMT, invasion and metastasis in breast cancer. In the present study, we examined whether ER...
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Inflammatory breast cancer (IBC) is the most insidious form of locally advanced breast cancer; about a third of patients have distant metastasis at initial staging. Emerging evidence suggests that host factors in the tumor microenvironment may interact with underlying IBC cells to make them aggressive. It is unknown whether immune cells associated to the IBC microenvironment play...
For clinically node-positive breast cancer patients receiving neoadjuvant chemotherapy, approximately 40 % will be found to be pathologically node negative. The American College of Surgeons Oncology Group Z1071 trial was therefore conducted to evaluate sentinel lymph node dissection (SLND) in these patients. The trial’s primary end point was to determine the false-negative rate...
Inflammatory breast cancer is the most aggressive form of breast cancer. Identifying new biomarkers to be used as therapeutic targets is in urgent need. Messenger RNA expression profiling studies have indicated that inflammatory breast cancer is a transcriptionally heterogeneous disease, and specific molecular targets for inflammatory breast cancer have not been well established...
