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Licensed Dengue Vaccine: Public Health Conundrum and Scientific Challenge

June 27, 2016. Author’s address: Scott B. Halstead, Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, E-mail: . This is an open

Dengue Vascular Permeability Syndrome: What, No T Cells?

Clinical Infectious Diseases Correspondence Dengue Vascular Permeability Syndrome: What 0 No T Cells? 0 0 Scott B. Halstead Dengue Vaccine Initiative, International Vaccine Institute , Seoul , Korea

Dengue: The Syndromic Basis to Pathogenesis Research. Inutility of the 2009 WHO Case Definition

Scott B. Halstead halsteads@erols.com 0 1 0 N. Bethesda, MD 20852 1 Dengue Vaccine Initiative, International Vaccine Institute , Seoul , Korea - Dengue diseases comprise major health problems for ... address: Scott B. Halstead, Dengue Vaccine Initiative, International Vaccine Institute, Seoul, Korea, E-mail: halsteads@erols.com.

Economic and Disease Burden of Dengue in Mexico

Background Dengue imposes a substantial economic and disease burden in most tropical and subtropical countries. Dengue incidence and severity have dramatically increased in Mexico during the past decades. Having objective and comparable estimates of the economic burden of dengue is essential to inform health policy, increase disease awareness, and assess the impact of dengue ...

Approaches to Refining Estimates of Global Burden and Economics of Dengue

Dengue presents a formidable and growing global economic and disease burden, with around half the world's population estimated to be at risk of infection. There is wide variation and substantial uncertainty in current estimates of dengue disease burden and, consequently, on economic burden estimates. Dengue disease varies across time, geography and persons affected. Variations in ...

Controlling Dengue with Vaccines in Thailand

Background Dengue is a mosquito-borne infectious disease that constitutes a growing global threat with the habitat expansion of its vectors Aedes aegyti and A. albopictus and increasing urbanization. With no effective treatment and limited success of vector control, dengue vaccines constitute the best control measure for the foreseeable future. With four interacting dengue ...

Japanese Encephalitis: New Options for Active Immunization

Japanese encephalitis (JE) is a mosquito-borne flavivirus infection responsible for significant morbidity and mortality across Asia. Indigenous populations and those who undertake short- and long-term travel to endemic regions are at risk of infection and development of neuroinvasive disease. Effective mouse brain-derived vaccines have been available in select countries, including ...

Measuring Dengue Enhancing Antibodies: Caveats

Scott B. Halstead 0 0 Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences , Bethesda. Maryland - To the Editor-Laoprasopwattana et al. [1

Natural History of Dengue Virus (DENV)—1 and DENV—4 Infections: Reanalysis of Classic Studies

Background. The natural history of wild-type dengue virus (DENV) infections of humans, including incubation and infectious periods, requires further study. Methods. Two experimental studies in the Philippines of DENV-4 (1924–1925) and DENV-1 (1929–1930) were reexamined. The intrinsic incubation periods were fitted to log-normal distribution using the maximum likelihood method, and ...

BIOLOGIC PROPERTIES OF DENGUE VIRUSES FOLLOWING SERIAL PASSAGE IN PRIMARY DOG KIDNEY CELLS: STUDIES AT THE UNIVERSITY OF HAWAII

address: Scott B. Halstead, Department of Preventive Medicine and Biometrics, Uniformed Services University of Health Sciences , 5824 Edson Lane, North Bethesda, MD 20852, Fax: 301- 984-8042 Serial passage

Best Practices in Dengue Surveillance: A Report from the Asia-Pacific and Americas Dengue Prevention Boards

Background Dengue fever is a virus infection that is spread by the Aedes aegypti mosquito and can cause severe disease especially in children. Dengue fever is a major problem in tropical and sub-tropical regions of the world. Methodology/Principal Findings We invited dengue experts from around the world to attend meetings to discuss dengue surveillance. We reviewed literature, ...

DENGUE HEMORRHAGIC FEVER CAUSED BY SEQUENTIAL DENGUE 1–3 VIRUS INFECTIONS OVER A LONG TIME INTERVAL: HAVANA EPIDEMIC, 2001–2002

A dengue epidemic caused by dengue virus 3 (DENV-3) occurred in Cuba in 2001–2002. It included cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). We report neutralizing antibody studies on sera from 54 of 78 DHF/DSS patients that provide evidence of infections occurring in the sequence DENV-1 followed by DENV-3. No sera showed infection in the sequence DENV-2 ...

Cost of Dengue Cases in Eight Countries in the Americas and Asia: A Prospective Study

Despite the growing worldwide burden of dengue fever, the global economic impact of dengue illness is poorly documented. Using a common protocol, we present the first multicountry estimates of the direct and indirect costs of dengue cases in eight American and Asian countries. We conducted prospective studies of the cost of dengue in five countries in the Americas (Brazil, El ...

Epidemiologic Studies on Dengue in Santiago de Cuba, 1997

Microbiology and Immunology, Johns Hopkins School of Hygiene and Public Health , Baltimore, MD. Reprint requests to Dr. Scott B. Halstead, 5824 Edson Lane, N. Bethesda, MD 20852 ( 1 Provincial Public Health and

Dr. Guzmán et al. Respond to Dr. Vaughn

Immunology, Johns Hopkins School of Hygiene and Public Health , Baltimore, MD. Reprint requests to Dr. Scott B. Halstead, 5824 Edson Lane, N. Bethesda, MD 20852 ( 1 Provincial Public Health and Epidemiology

Immunogenicity of Live Attenuated SA14-14-2 Japanese Encephalitis Vaccine—A Comparison of 1- and 3-Month Immunization Schedules

Live attenuated SA14-14-2 Japanese encephalitis (JE) vaccine has been safe and effective in < 100 million immunized children, but its current administration schedule of two doses given a year apart does not lend itself to inclusion in established Expanded Program of Immunization (EPI) schedules of childhood immunization. Immune responses to immunization at shorter intervals were ...

VOLUME REPLACEMENT IN INFANTS WITH DENGUE HEMORRHAGIC FEVER/DENGUE SHOCK SYNDROME

Volume replacement was studied prospectively in 208 infants with dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). The mean volume of intravenous fluid used was 110.4 mL/kg administered over a mean period of 25.8 hours. The mean volumes of intravenous fluid replacement in infants with DSS was significantly higher than in those with non-shock DHF (129.8 mL/kg versus 102.1 ...

ASSOCIATION BETWEEN SEX, NUTRITIONAL STATUS, SEVERITY OF DENGUE HEMORRHAGIC FEVER, AND IMMUNE STATUS IN INFANTS WITH DENGUE HEMORRHAGIC FEVER

CHING-CHUAN LIU 0 SCOTT B. HALSTEAD 0 0 Department of Dengue Hemorrhagic Fever, Children's Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Microbiology and Immunology, Department of Medical

Dengue Hemorrhagic Fever in Infants: A Study of Clinical and Cytokine Profiles

A prospective study of clinical and cytokine profiles of 107 infants with dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) was conducted. Fever, petechiae on the skin, and hepatomegaly were the most common clinical findings associated with DHF/DSS in infants. DSS occurred in 20.5% of the patients. Hemoconcentration and thrombocytopenia were observed in 91.5% and 92.5% of ...