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Reliability of plasma polar metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry

of the Tsuruoka Metabolomic Cohort Study team for their commitment to the project. Author Contributions Conceptualization: Sei Harada, Akiyoshi Hirayama, Toru Takebayashi. Data curation: Sei Harada ... , Akiyoshi Hirayama, Masahiro Sugimoto, Toru Takebayashi. Formal analysis: Sei Harada, Timothy M. D. Ebbels. Funding acquisition: Sei Harada, Paul Elliott, Masaru Tomita, Tomoyoshi Soga, Toru Takebayashi

Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men

Objective Physical activity is known to be preventive against various non-communicable diseases. We investigated the relationship between daily physical activity level and plasma metabolites using a targeted metabolomics approach in a population-based study. Methods A total of 1,193 participants (male, aged 35 to 74 years) with fasting blood samples were selected from the...

Metabolomic profiling reveals novel biomarkers of alcohol intake and alcohol-induced liver injury in community-dwelling men

Objective Metabolomics is a promising approach to the identification of biomarkers in plasma. Here, we performed a population-based, cross-sectional study to identify potential biomarkers of alcohol intake and alcohol-induced liver injury by metabolomic profiling using capillary electrophoresis-mass spectrometry (CE-MS). Methods Fasting plasma samples were collected from 896...

Circulating AIM as an Indicator of Liver Damage and Hepatocellular Carcinoma in Humans

Izumino Jun Takahashi Kayo Aoyama Sei Harada Toru Takebayashi Toshiaki Gunji Shin Ohnishi Shinji Seto Yukio Yoshida Yoichi Hiasa Kazuhiko Koike Ken-ichi Yamamura Ken-ichiro Inoue Toru Miyazaki Kalpana