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Multistate Markov model for predicting the natural disease progression of type 2 diabetes based on hemoglobin A1c

Introduction: Type 2 diabetes is a common non-communicable disease, especially in developing countries like India, posing a huge economic burden on the family and nation as a whole. It is a chronic metabolic disorder in which prevalence has been increasing steadily all over the world. In studies of many chronic medical conditions, the health status of a patient may be...

Factors Associated with Perceived Susceptibility to COVID-19 Among Urban and Rural Adults in Alabama

We examined factors associated with and reasons for perceived susceptibility to COVID-19 among urban and rural adults in Alabama. We surveyed 575 eligible participants’ engagement in preventive behaviors, concern about COVID-19 in their communities, perceived susceptibility to the virus, and reasons for susceptibility across three response options (Yes, No, and Don’t Know/Not...

Biological and Clinical Significance of the CCR5/CCL5 Axis in Hepatocellular Carcinoma

Despite the improvement in survival for patients with liver cancer (LCa) in recent decades, only one in five patients survive for 5 years after diagnosis. Thus, there is an urgent need to find new treatment options to improve patient survival. For various cancers, including LCa, the chemokine CCL5 (RANTES) facilitates tumor progression and metastasis. Since the function of the...

CC chemokines are differentially expressed in Breast Cancer and are associated with disparity in overall survival

Despite recent advances, breast cancer (BrCa) still affects many women and the impact is disproportional in African Americans (AA) compared to European Americans (EA). Addressing socioeconomic and behavioral status has not been enough to reduce disparity, suggesting contribution of biological differences in BrCa disparity. Our laboratory was first to show involvement of CC...

Ficolin-2 binds to serotype 35B pneumococcus as it does to serotypes 11A and 31, and these serotypes cause more infections in older adults than in children

Serotypes? as the reference. (DOCX) Author Contributions Conceptualization: K. Aaron Geno, Moon H. Nahm. Data curation: K. Aaron Geno, Brady L. Spencer. Formal analysis: K. Aaron Geno, Sejong Bae ... . Funding acquisition: Moon H. Nahm. Investigation: K. Aaron Geno. 9 / 11 Methodology: K. Aaron Geno, Brady L. Spencer, Sejong Bae, Moon H. Nahm. Project administration: Moon H. Nahm. Supervision: Moon H

Higher CXCL16 exodomain is associated with aggressive ovarian cancer and promotes the disease by CXCR6 activation and MMP modulation

Ovarian cancer (OvCa) is the leading cause of death from gynecological malignancies. Five-year survival rate of OvCa ranges from 30–92%, depending on the spread of disease at diagnosis. Role of chemokines is well appreciated in cancer, including OvCa. However, their precise role is understudied. Here, we show clinical and biological significance of CXCR6-CXCL16 and ADAM10 in OvCa...

The bio-sonographic index. A novel modality for early detection of acute kidney injury after complex vascular surgery. A protocol for an exploratory prospective study

Berkowitz. Data curation: Ahmed Zaky, Sejong Bae, Adam Sturdivant, Nicole McAnally, Ashita Tolwani. Formal analysis: Ahmed Zaky, Sejong Bae, Nicole McAnally, Ashita Tolwani. Funding acquisition: Ahmed Zaky ... , Adam Sturdivant, Ashita Tolwani, Dan Berkowitz. Investigation: Ahmed Zaky, J. F. Pittet, Ashita Tolwani, Dan Berkowitz. Methodology: Ahmed Zaky, Adam W. Beck, Sejong Bae, Adam Sturdivant, Amandiy Liwo

AR negative triple negative or “quadruple negative” breast cancers in African American women have an enriched basal and immune signature

for their technical assistance, comments and discussions. Author Contributions Conceptualization: Melissa Davis, Windy Colomb, Clayton Yates. Formal analysis: Qinghua He, Sejong Bae. Funding

Intentional tanning behaviors among undergraduates on the United States’ Gulf Coast

Rates of melanoma have dramatically increased among adolescents and young adults in recent years, particularly among young women. Exposure to ultraviolet radiation from intentional tanning practices is likely a major contributor to this epidemic. Southern and coastal regions have higher melanoma mortality rates among non-Hispanic whites in other parts of the U.S., yet little is...

CCR5/CCL5 axis interaction promotes migratory and invasiveness of pancreatic cancer cells

journals • PubMed • Google Scholar Search for Isam-Eldin A. Eltoum in:Nature Research journals • PubMed • Google Scholar Search for Sejong Bae in:Nature Research journals • PubMed • Google Scholar Search ... performed experiments, analyzed data, and wrote the manuscript. Manoj K. Mishra, Isam-Eldin A. Eltoum, Sejong Bae and James W. Lillard Jr. critically reviewed the manuscript. Rajesh Singh conceived and

Correction to: Prognostic impact of immune gene expression signature and tumor infiltrating immune cells in localized clear cell renal cell carcinoma

, Birmingham, AL, 35233, USAJennifer Gordetsky, Sejong Bae, Gurudatta Naik & Guru SonpavdeMemorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USAFengshen Kuo, Timothy A. Chan & A. Ari ... Scholar Search for Sejong Bae in:PubMed • Google Scholar Search for Gurudatta Naik in:PubMed • Google Scholar Search for Timothy A. Chan in:PubMed • Google Scholar Search for Robert Uzzo in:PubMed

Prognostic impact of immune gene expression signature and tumor infiltrating immune cells in localized clear cell renal cell carcinoma

The tumor immune microenvironment has become the focus of research in clear cell renal cell carcinoma (ccRCC) due to its important role in immune surveillance post nephrectomy. This study investigates the correlation of tumor infiltrating immune cell characteristics with rates of recurrence following surgery in localized ccRCC. We morphologically identified and scored tumor...

A higher degree of expression of DNA methyl transferase 1 in cervical cancer is associated with poor survival outcome

Sejong Bae,3 Roland Matthews,4 Walter C Bell,2 Edward E Partridge5 1Department of Nutrition Sciences, 2Department of Pathology, 3Department of Medicine, The University of Alabama at Birmingham, Birmingham

Dietary supplementation and the quality of life of retired football players

Robert A Sinnott 0 Rolando L Maddela 0 Sejong Bae Talitha Best 0 Research and Development , Mannatech, Incorporated, 600 S Royal Lane Suite 200, Coppell, TX 75019 , USA - From International

Recent trends in racial and regional disparities in cervical cancer incidence and mortality in United States

Background Although black women experienced greater cervical cancer incidence and mortality rate reduction in recent years, they continue to have higher incidence rates than whites. Great variations also exist among geographic regions of the US, with the South having both the highest incidence and mortality rates compared to other regions. The present study explores the question...

MicroRNA-200c and microRNA- 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer

in:PubMed • Google Scholar Search for Liyan Sun in:PubMed • Google Scholar Search for Sejong Bae in:PubMed • Google Scholar Search for Dongquan Chen in:PubMed • Google Scholar Search for Shi Wei in:PubMed

Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling

The tumor suppressor protein Merlin is proteasomally degraded in breast cancer. We undertook an untargeted metabolomics approach to discern the global metabolomics profile impacted by Merlin in breast cancer cells. We discerned specific changes in glutathione metabolites that uncovered novel facets of Merlin in impacting the cancer cell metabolome. Concordantly, Merlin loss...

Factors associated with attention deficit/hyperactivity disorder among US children: Results from a national survey

the manuscript. Bradford E. Jackson helped in data analysis and drafting of the manuscript. Sejong Bae supervised Ravi Lingineni in analysis using complex survey procedures in SAS and revision of the

Factors associated with attention deficit/hyperactivity disorder among US children: Results from a national survey

the manuscript. Sejong Bae supervised Ravi Lingineni in analysis using complex survey procedures in SAS and revision of the manuscript. Karan P. Singh supervised the whole group, helped in the