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Upregulation of inducible NO synthase by exogenous adenosine in vascular smooth muscle cells activated by inflammatory stimuli in experimental diabetes

Background Adenosine has been shown to induce nitric oxide (NO) production via inducible NO synthase (iNOS) activation in vascular smooth muscle cells (VSMCs). Although this is interpreted as a beneficial vasodilating pathway in vaso-occlusive disorders, iNOS is also involved in diabetic vascular dysfunction. Because the turnover of and the potential to modulate iNOS by adenosine...

Upregulation of inducible NO synthase by exogenous adenosine in vascular smooth muscle cells activated by inflammatory stimuli in experimental diabetes

Adenosine has been shown to induce nitric oxide (NO) production via inducible NO synthase (iNOS) activation in vascular smooth muscle cells (VSMCs). Although this is interpreted as a beneficial vasodilating pathway in vaso-occlusive disorders, iNOS is also involved in diabetic vascular dysfunction. Because the turnover of and the potential to modulate iNOS by adenosine in...

Bisdemethoxycurcumin and Its Cyclized Pyrazole Analogue Differentially Disrupt Lipopolysaccharide Signalling in Human Monocyte-Derived Macrophages

; Published 8 February 2018 Academic Editor: Vinod K. Mishra Copyright © 2018 Serena Tedesco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits ... . Authors’ Contributions Morena Zusso, Chiara Bolego, Pietro Giusti, and Andrea Cignarella conceived and designed the experiments. Serena Tedesco, Laura Facci, Annalisa Trenti, and Carlotta Boscaro performed

Bisdemethoxycurcumin and Its Cyclized Pyrazole Analogue Differentially Disrupt Lipopolysaccharide Signalling in Human Monocyte-Derived Macrophages

Giusti, and Andrea Cignarella conceived and designed the experiments. Serena Tedesco, Laura Facci, Annalisa Trenti, and Carlotta Boscaro performed the experiments. Federica Belluti synthesized and provided ... the GG6 and GG9. Serena Tedesco, Morena Zusso, Laura Facci, Gian Paolo Fadini, and Chiara Bolego analysed the data. Andrea Cignarella and Stephen D. Skaper wrote the paper. All authors read and approved

Bisdemethoxycurcumin and Its Cyclized Pyrazole Analogue Differentially Disrupt Lipopolysaccharide Signalling in Human Monocyte-Derived Macrophages

; Published 8 February 2018 Academic Editor: Vinod K. Mishra Copyright © 2018 Serena Tedesco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits ... . Authors’ Contributions Morena Zusso, Chiara Bolego, Pietro Giusti, and Andrea Cignarella conceived and designed the experiments. Serena Tedesco, Laura Facci, Annalisa Trenti, and Carlotta Boscaro performed