14 papers found.

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K-Ras is a key driver of oncogenesis, accounting for approximately 80% of Ras-driven human cancers. The small GTPase cycles between an inactive, GDP-bound and an active, GTP-bound state, regulated by guanine nucleotide exchange factors and GTPase activating proteins, respectively. Activated K-Ras regulates cell proliferation, differentiation and survival by signaling through...

We revisit the D0 bound state problems, of the M/IIA duality, with the Orientifolds. The cases of O4 and O8 have been studied recently, from the perspective of five-dimensional theories, while the case of O0 has been much neglected. The computation we perform for D0-O0 states boils down to the Witten indices for \( \mathcal{N}=16 \) O(m) and Sp(n) quantum mechanics, where we...

In this work we systematically enumerate genus one fibrations in the class of 7, 890 Calabi-Yau manifolds defined as complete intersections in products of projective spaces, the so-called CICY threefolds. This survey is independent of the description of the manifolds and improves upon past approaches that probed only a particular algebraic form of the threefolds (i.e. searches...

Among gauged dynamics motivated by string theory, we find many with gapless asymptotic directions. Although the natural boundary condition for ground states is L 2, one often turns on chemical potentials or supersymmetric mass terms to regulate the infrared issues, instead, and computes the twisted partition function. We point out how this procedure generically fails to capture...

We provide a set of tools for analyzing the geometry of elliptically fibered Calabi-Yau manifolds, starting with a description of the total space rather than with a Weierstrass model or a specified type of fiber/base. Such an approach to the subject of F-theory compactification makes certain geometric properties, which are usually hidden, manifest. Specifically, we review how to...

In this work we explore the physics associated to Calabi-Yau (CY) n-folds that can be described as a fibration in more than one way. Beginning with F-theory vacua in various dimensions, we consider limits/dualities with M-theory, type IIA, and heterotic string theories. Our results include many M-/F-theory correspondences in which distinct F-theory vacua — associated to different...

We explore Seiberg-like dualities, or mutations, for \( \mathcal{N}=4 \) quiver quantum mechanics in the context of wall-crossing. In contrast to higher dimensions, the 1d Seiberg-duality must be performed with much care. With fixed Fayet-Iliopoulos constants, at most two nodes can be mutated, one left and the other right, mapping a chamber of a quiver into a chamber of a mutated...

We study heterotic model building on 16 specific Calabi-Yau manifolds constructed as hypersurfaces in toric four-folds. These 16 manifolds are the only ones among the more than half a billion manifolds in the Kreuzer-Skarke list with a non-trivial first fundamental group. We classify the line bundle models on these manifolds, both for SU(5) and SO(10) GUTs, which lead to...

We count Higgs “phase” BPS states of general non-Abelian quiver, possibly with loops, by mapping the problem to its Abelian, or toric, counterpart and imposing Weyl invariance later. Precise Higgs index computation is particularly important for quivers with superpotentials; the Coulomb “phase” index is recently shown to miss important BPS states, dubbed intrinsic Higgs states or...

In immunocompetent individuals, non-typhoidal Salmonella serovars (NTS) are associated with gastroenteritis, however, there is currently an epidemic of NTS bloodstream infections in sub-Saharan Africa. Plasmodium falciparum malaria is an important risk factor for invasive NTS bloodstream in African children. Here we investigated whether a live, attenuated Salmonella vaccine could...

We demonstrate a new solution-processed electron transport layer (ETL), zinc oxide doped with cesium carbonate (ZnO:Cs2CO3), for achieving organic photovoltaics (OPVs) with good operational stability at ambient air. An OPV employing the ZnO:Cs2CO3 ETL exhibits a fill factor of 62%, an open circuit voltage of 0.90 V, and a short circuit current density of −6.14 mA/cm2 along with 3...

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when both ATP and CTP are present together with
dTTP, the overall DNA binding level is decreased, yet
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Respirators are used to help reduce exposure to a variety of contaminants in workplaces. Test aerosols used for certification of particulate respirators (PRs) include sodium chloride (NaCl), dioctyl phthalate, and paraffin oil. These aerosols are generally assumed to be worst case surrogates for aerosols found in the workplace. No data have been published to date on the...

Pathogens can substantially alter gene expression within an infected host depending on metabolic or virulence requirements in different tissues, however, the effect of these alterations on host immunity are unclear. Here we visualized multiple CD4 T cell responses to temporally expressed proteins in Salmonella-infected mice. Flagellin-specific CD4 T cells expanded and contracted...