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The burden of hepatitis B virus (HBV) infection, genotypes and drug resistance mutations in human immunodeficiency virus-positive patients in Northwest Ethiopia

, Kevin Fonseca, Shan Gao, Ebba Abate, Yetemwork Aleka, Mark G. Swain, Guido van Marle, Carla S. Coffin. Formal analysis: Tekalign Deressa, Debasu Damtie, Kevin Fonseca, Shan Gao, Ebba Abate, Shitaye ... Fonseca, Shan Gao, Ebba Abate, Shitaye Alemu, Yetemwork Aleka, Mark G. Swain, Guido van Marle, Carla S. Coffin. Methodology: Tekalign Deressa, Shan Gao, Ebba Abate, Shitaye Alemu, Yetemwork Aleka. Project

Leptin-adiponectin imbalance as a marker of metabolic syndrome among Chinese children and adolescents: The BCAMS study

Fu, Qian Zhang, Naishi Li. Methodology: Xinhua Xiao, Changhong Li, Jie Mi, Shan Gao, Ming Li. Project administration: Jie Mi, Ming Li. Resources: Jie Mi, Ming Li. Writing ± original draft: Ge Li ... . Writing ± review & editing: Yanglu Zhao, Shan Gao, Ming Li. 11 / 14 12 / 14 MONICA / KORA Augsburg study 1984±2002. Diabetic medicine. 2010; 27(9):1004±11. Epub 2010/08/ 21. https://doi.org/10.1111/j.1464

Histone methyltransferase TXR1 is required for both H3 and H3.3 lysine 27 methylation in the well-known ciliated protist Tetrahymena thermophila

University of China, for providing in vivo and protogal staining pictures of Tetrahymena. This work was supported by the Natural Science Foundation of China (31470064, 31522051 to Shan Gao), the National

Two featured series of rRNA-derived RNA fragments (rRFs) constitute a novel class of small RNAs

In this study, we reported two featured series of rRNA-derived RNA fragments (rRFs) from the small RNA sequencing (sRNA-seq) data of Amblyomma testudinarium using the Illunima platform. Two series of rRFs (rRF5 and rRF3) were precisely aligned to the 5' and 3' ends of the 5.8S and 28S rRNA gene. The rRF5 and rRF3 series were significantly more highly expressed than the rRFs...

An Ultrasensitive Gold Nanoparticle-based Lateral Flow Test for the Detection of Active Botulinum Neurotoxin Type A

Botulism is a severe and potentially lethal paralytic disease caused by several botulinum neurotoxin-producing Clostridia spp. In China, the majority of the cases caused by botulism were from less-developed rural areas. Here, we designed specific substrate peptides and reconfigured gold nanoparticle-based lateral flow test strip (LFTS) to develop an endopeptidase-based lateral...

Enzymatic and chemical mapping of nucleosome distribution in purified micro- and macronuclei of the ciliated model organism, Tetrahymena thermophila

Genomic distribution of the nucleosome, the basic unit of chromatin, contains important epigenetic information. To map nucleosome distribution in structurally and functionally differentiated micronucleus (MIC) and macronucleus (MAC) of the ciliate Tetrahymena thermophila, we have purified MIC and MAC and performed micrococcal nuclease (MNase) digestion as well as hydroxyl radical...

Minimally invasive percutaneous nephrolithotomy improves stone-free rates for impacted proximal ureteral stones: A systematic review and meta-analysis

Background Urinary stones are common medical disorders and the treatment of impacted proximal ureteral stones (IPUS) is still a challenge for urologists. The aim of this study was to compare the efficacy and safety of minimally invasive percutaneous nephrolithotomy (MI-PCNL) and ureteroscopic lithotripsy (URL) in the treatment of IPUS via a meta-analysis. Methods We collected...

Vitamin D modifies the associations between circulating betatrophin and cardiometabolic risk factors among youths at risk for metabolic syndrome

Background Betatrophin has been recently reported to play a role in glucose homeostasis by inducing beta-cell proliferation in mice. However, studies in human are inconsistent. As a nutritionally-regulated liver-enriched factor, we hypothesize that betatrophin might be regulated by vitamin D, and ignorance of vitamin D status may explain the discrepancy in previous human studies...

Plaque distribution of low-grade basilar artery atherosclerosis and its clinical relevance

0 Shan Gao 0 Wei-Hai Xu 0 0 Department of Neurology and Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences , Shuaifuyuan1, Dongcheng District, Beijing 100730 , China

Generation of a de novo transcriptome from equine lamellar tissue

Background Laminitis, the structural failure of interdigitated tissue that suspends the distal skeleton within the hoof capsule, is a devastating disease that is the second leading cause of both lameness and euthanasia in the horse. Current transcriptomic research focuses on the expression of known genes. However, as this tissue is quite unique and equine gene annotation is...

Proteomic Analyses Reveal the Mechanism of Dunaliella salina Ds-26-16 Gene Enhancing Salt Tolerance in Escherichia coli

We previously screened the novel gene Ds-26-16 from a 4 M salt-stressed Dunaliella salina cDNA library and discovered that this gene conferred salt tolerance to broad-spectrum organisms, including E. coli (Escherichia coli), Haematococcus pluvialis and tobacco. To determine the mechanism of this gene conferring salt tolerance, we studied the proteome of E. coli overexpressing the...

Dissecting relative contributions of cis- and trans-determinants to nucleosome distribution by comparing Tetrahymena macronuclear and micronuclear chromatin

The ciliate protozoan Tetrahymena thermophila contains two types of structurally and functionally differentiated nuclei: the transcriptionally active somatic macronucleus (MAC) and the transcriptionally silent germ-line micronucleus (MIC). Here, we demonstrate that MAC features well-positioned nucleosomes downstream of transcription start sites and flanking splice sites...

Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies

, Jun Liu, Catherine W-H. Zhang, Jianxun Qi, Jinghua Yan, Shan Gao, George F. Gao declare that they have no conflict of interest. This article does not contain any studies with human or animal subjects

Takayasu arteritis presenting with massive cerebral ischemic infarction in a 35-year-old woman: a case report

Shan Gao 0 Ruilan Wang 0 0 Intensive Care Unit, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University , 650 Xinsongjiang Road, Shanghai 201620 , China Introduction

RNA sequencing analysis to capture the transcriptome landscape during skin ulceration syndrome progression in sea cucumber Apostichopus japonicus

Background Sea cucumber Apostichopus japonicus is an important economic species in China, which is affected by various diseases; skin ulceration syndrome (SUS) is the most serious. In this study, we characterized the transcriptomes in A. japonicus challenged with Vibrio splendidus to elucidate the changes in gene expression throughout the three stages of SUS progression. Results...

Genome-wide analysis of Dongxiang wild rice (Oryza rufipogon Griff.) to investigate lost/acquired genes during rice domestication

Background It is widely accepted that cultivated rice (Oryza sativa L.) was domesticated from common wild rice (Oryza rufipogon Griff.). Compared to other studies which concentrate on rice origin, this study is to genetically elucidate the substantially phenotypic and physiological changes from wild rice to cultivated rice at the whole genome level. Results Instead of comparing...

Sparse Differential Resultant for Laurent Differential Polynomials

In this paper, we first introduce the concept of Laurent differentially essential systems and give a criterion for a Laurent differential polynomial system to be Laurent differentially essential in terms of its support matrix. Then, the sparse differential resultant for a Laurent differentially essential system is defined, and its basic properties are proved. In particular, order...